From Childhood Obesity to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hyperlipidemia Through Oxidative Stress During Childhood DOI Creative Commons

Siham Accacha,

Julia Barillas-Cerritos,

Ankita Srivastava

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 287 - 287

Published: April 24, 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is rapidly becoming the most prevalent form of chronic in both pediatric and adult populations. It encompasses a wide spectrum abnormalities, ranging from simple fat accumulation to severe conditions such inflammation, fibrosis, cirrhosis, cancer. Major risk factors for MASLD include obesity, insulin resistance, type 2 diabetes, hypertriglyceridemia. Methods: This narrative review employed comprehensive search recent literature identify latest studies on relationship between MAFLD health consequences treatment options prevent long-term damage other organs. Additionally, article presents perspectives diagnostic biomarkers. Results: Childhood obesity linked multitude comorbid remains primary factor obesity. abnormal have detrimental effects into adulthood. Scientific evidence unequivocally demonstrates role obesity-related conditions, dyslipidemia, hyperglycemia, development progression MASLD. Oxidative stress, stemming mitochondrial dysfunction, leading discusses interconnections oxidative Conclusions: Atherogenic endothelial cytokines collectively contribute Potential targets are focused prevention use drugs address elevated blood lipid levels.

Language: Английский

From Childhood Obesity to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hyperlipidemia Through Oxidative Stress During Childhood DOI Creative Commons

Siham Accacha,

Julia Barillas-Cerritos,

Ankita Srivastava

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 287 - 287

Published: April 24, 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is rapidly becoming the most prevalent form of chronic in both pediatric and adult populations. It encompasses a wide spectrum abnormalities, ranging from simple fat accumulation to severe conditions such inflammation, fibrosis, cirrhosis, cancer. Major risk factors for MASLD include obesity, insulin resistance, type 2 diabetes, hypertriglyceridemia. Methods: This narrative review employed comprehensive search recent literature identify latest studies on relationship between MAFLD health consequences treatment options prevent long-term damage other organs. Additionally, article presents perspectives diagnostic biomarkers. Results: Childhood obesity linked multitude comorbid remains primary factor obesity. abnormal have detrimental effects into adulthood. Scientific evidence unequivocally demonstrates role obesity-related conditions, dyslipidemia, hyperglycemia, development progression MASLD. Oxidative stress, stemming mitochondrial dysfunction, leading discusses interconnections oxidative Conclusions: Atherogenic endothelial cytokines collectively contribute Potential targets are focused prevention use drugs address elevated blood lipid levels.

Language: Английский

Citations

0