Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2895 - 2895

Published: March 22, 2025

Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.

Language: Английский

Exploring the Cardiovascular Potential of Artichoke—A Comprehensive Review

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 397 - 397

Published: April 10, 2025

Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, requiring both pharmacological lifestyle-based preventive strategies. Artichoke (Cynara cardunculus L. var. scolymus) has gained attention for its health benefits, including choleretic lipid-lowering activities. However, cardiovascular effects remain underdiscussed. This paper provides critical review the current literature on artichoke, with focus underlying mechanisms action clinical efficacy. Experimental studies assessing artichoke’s endothelial function, vascular smooth muscle relaxation, modulation renin–angiotensin–aldosterone axis were assessed. Additionally, studies, systematic reviews, meta-analyses investigating antihypertensive reviewed. bioactive components, particularly flavonoids caffeoylquinic acids, enhance endothelial-dependent -independent vasorelaxation inhibit angiotensin-converting enzyme activity. Although indicate improvements in flow-mediated dilation, they report only modest reductions blood pressure, high variability formulations, dosages, patient populations. While artichoke supplementation may support pressure regulation health, evidence suggests it should be considered an adjunct rather than replacement conventional therapy. Standardized formulations well-controlled will required to clarify therapeutic role.

Language: Английский

Obesity and nutritional strategies: advancing prevention and management through evidence-based approaches

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 20, 2025

Language: Английский