Predictive Factors for COVID-19 Severity in Patients with Axial Spondyloarthritis: Real-World Data from the Romanian Registry of Rheumatic Diseases DOI Creative Commons
Andreea-Iulia Vlădulescu-Trandafir,

Violeta‐Claudia Bojincă,

Cristina Raluca Gh. Popescu

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 411 - 411

Published: Feb. 26, 2025

Background and Objectives: Coronavirus disease-2019 (COVID-19) posed unique challenges worldwide, underscoring important gaps in healthcare preparedness for patients receiving immunosuppressive therapies, such as the individuals with axial spondyloarthritis (axSpA), a subgroup of (SpA) characterized by chronic inflammation immune dysregulation. While global registry data exist SpA, specific on axSpA alone remain scarce, especially Central Eastern European populations. This study aims to identify predictive factors severe COVID-19 outcomes provide descriptive analysis infected acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using real-world from Romanian Registry Rheumatic Diseases (RRBR). Materials Methods: is three-year retrospective observational cohort that included 5.786 RRBR, whom 183 (3.16%) were diagnosed SARS-CoV-2 infection. Data analyzed R V4.4.1 performing univariate multivariate binary logistic regression estimate associations odds ratios (ORs), 95% confidence intervals (CIs), p-values. A backward selection algorithm was applied create final model, accounting multicollinearity through variance inflation (VIFs). Results: The mean age 48.19 ± 12.26 years, male predominance (64.5%). Serious (encompassing moderate critical cases) occurred 46 cases, ≥ 52.5 years (OR 2.64, CI: 1.28–5.48, p = 0.009) arterial hypertension 2.57, 1.29–5.16, 0.007) identified significant predictors. Individuals advanced education levels had nearly three times lower experiencing serious 0.38, 0.18–0.76, 0.008). Furthermore, our findings confirm lack association between HLA-B27 severity (p 0.194), contributing ongoing discussion regarding its potential immunological role. Moreover, irrespective biological therapy administered, likelihood not statistically 0.882). In only older higher deemed factors. Conclusions: highlights key predictors emphasizes protective role education, an underexplored determinant health inflammatory diseases. lessons learned during these last can shape more informed compassionate system.

Language: Английский

Predictive Factors for COVID-19 Severity in Patients with Axial Spondyloarthritis: Real-World Data from the Romanian Registry of Rheumatic Diseases DOI Creative Commons
Andreea-Iulia Vlădulescu-Trandafir,

Violeta‐Claudia Bojincă,

Cristina Raluca Gh. Popescu

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 411 - 411

Published: Feb. 26, 2025

Background and Objectives: Coronavirus disease-2019 (COVID-19) posed unique challenges worldwide, underscoring important gaps in healthcare preparedness for patients receiving immunosuppressive therapies, such as the individuals with axial spondyloarthritis (axSpA), a subgroup of (SpA) characterized by chronic inflammation immune dysregulation. While global registry data exist SpA, specific on axSpA alone remain scarce, especially Central Eastern European populations. This study aims to identify predictive factors severe COVID-19 outcomes provide descriptive analysis infected acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using real-world from Romanian Registry Rheumatic Diseases (RRBR). Materials Methods: is three-year retrospective observational cohort that included 5.786 RRBR, whom 183 (3.16%) were diagnosed SARS-CoV-2 infection. Data analyzed R V4.4.1 performing univariate multivariate binary logistic regression estimate associations odds ratios (ORs), 95% confidence intervals (CIs), p-values. A backward selection algorithm was applied create final model, accounting multicollinearity through variance inflation (VIFs). Results: The mean age 48.19 ± 12.26 years, male predominance (64.5%). Serious (encompassing moderate critical cases) occurred 46 cases, ≥ 52.5 years (OR 2.64, CI: 1.28–5.48, p = 0.009) arterial hypertension 2.57, 1.29–5.16, 0.007) identified significant predictors. Individuals advanced education levels had nearly three times lower experiencing serious 0.38, 0.18–0.76, 0.008). Furthermore, our findings confirm lack association between HLA-B27 severity (p 0.194), contributing ongoing discussion regarding its potential immunological role. Moreover, irrespective biological therapy administered, likelihood not statistically 0.882). In only older higher deemed factors. Conclusions: highlights key predictors emphasizes protective role education, an underexplored determinant health inflammatory diseases. lessons learned during these last can shape more informed compassionate system.

Language: Английский

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