Epigenetic Aging Acceleration in Obesity Is Slowed Down by Nutritional Ketosis Following Very Low-Calorie Ketogenic Diet (VLCKD): A New Perspective to Reverse Biological Age
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 1060 - 1060
Published: March 18, 2025
Background/Objectives:
Epigenetic
clocks
have
emerged
as
a
tool
to
quantify
biological
age,
providing
more
accurate
estimate
of
an
individual’s
health
status
than
chronological
helping
identify
risk
factors
for
accelerated
aging
and
evaluating
the
reversibility
therapeutic
strategies.
This
study
aimed
evaluate
potential
association
between
epigenetic
acceleration
age
obesity,
well
determine
whether
nutritional
interventions
body
weight
loss
could
slow
down
this
acceleration.
Methods:
Biological
was
estimated
using
three
(Horvath
(Hv),
Hannum
(Hn),
Levine
(Lv))
based
on
leukocyte
methylome
analysis
individuals
with
normal
(n
=
20),
obesity
24),
patients
following
VLCKD
10).
We
analyzed
differences
in
estimates,
relationship
impact
VLCKD.
Correlations
were
assessed
acceleration,
BMI,
various
metabolic
parameters.
Results:
Analysis
revealed
(Hv
+3.4(2.5),
Hn
+5.7(3.2),
Lv
+3.9(2.7))
compared
slight
deceleration
weight.
correlated
BMI
(p
<
0.0001).
Interestingly,
showed
both
ketosis
−3.3(4.0),
−6.3(5.3),
−8.8(4.5))
at
endpoint
−1.1(4.3),
−7.4(5.6),
−8.2(5.3)).
Relevantly,
slowdown
is
associated
0.0001),
ketonemia
≤
0.001),
parameters
0.05).
Conclusions:
Our
findings
highlight
applicability
monitor
obesity-related
precision
medicine
show
efficacy
slowing
aging.
Language: Английский
Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the “Traditional” Ketogenic Diet
Current Obesity Reports,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: April 3, 2025
This
narrative
review
comprehensively
analyzes
VLEKT
as
an
advanced
nutritional
strategy
for
obesity
management.
The
focus
is
on
the
beneficial
effects
key
disease
organs,
such
adipose
tissue
and
liver,
well
modulation
of
intestinal
permeability
its
fundamental
role
in
influencing
gut
microbiota
inflammatory
pathways.
impact
obesity-related
comorbidities,
including
metabolic
syndrome,
cardiovascular
disease,
endocrine
disorders,
dysfunction-associated
steatotic
liver
(MASLD),
neurological
kidney
alterations,
also
investigated.
Moreover,
to
assess
wider
application
treatment,
combination
ketogenic
regimes
with
additional
strategies
physical
activity,
bariatric
surgery,
digital
health
technologies
examined.
Despite
promising
clinical
results,
adherence
potential
deficiencies
require
careful
follow-up
individualized
programming
monitored
by
specialists.
Future
research
should
elucidating
molecular
mechanisms
underlying
physiological
systems,
long-term
safety.
Nevertheless,
innovative
approach
offering
a
target-oriented
highly
effective
people
fighting
against
overweight
associated
medical
complications.
Obesity
multifactorial
chronic
numerous
comorbidities;
given
increasing
prevalence,
personalized
intervention
are
crucial
inhibit
"obesity
pandemic"
according
"food
re-educational"
protocol.
Among
dietary
interventions,
diet
(KD)
has
attracted
attention
effectiveness
weight
management
benefits.
A
variant,
very
low-calorie
(VLCKD),
more
recently
defined
low-energy
(VLEKD),
combines
benefits
ketosis
substantial
calorie
restriction,
improving
overall
health.
Language: Английский