N-Acetylcysteine Attenuates Aβ-Mediated Oxidative Stress, Blood–Brain Barrier Leakage, and Renal Dysfunction in 5xFAD Mice DOI Open Access
Atcharaporn Ontawong, Geetika Nehra, Bryan Maloney

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4352 - 4352

Published: May 3, 2025

Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) pathology and closely linked to oxidative stress, which contributes blood–brain barrier leakage, renal dysfunction, cognitive decline. We investigated the effects of N-acetyl cysteine (NAC), an FDA-approved antioxidant, on brain Aβ levels, function, cognition in 5xFAD mice. Eight-week-old mice were fed a rodent diet supplemented with 600 mg/kgDiet NAC for 4 weeks; wild-type (WT) control regular diet. detected elevated 4-hydroxynonenal(4-HNE) reduced creatinine clearance, increased plasma S100β levels untreated compared WT controls. Untreated also had higher capillary P-gp activity, impaired WT. treatment Aβ40 normalized 4-HNE improved decreased lowered levels. performance mice, as shown Y-maze. Our findings indicate that Aβ-induced stress impairment, deficits Notably, mitigates these effects, suggesting its potential adjunct therapy AD other Aβ-related pathologies reducing stress.

Language: Английский

N-Acetylcysteine Attenuates Aβ-Mediated Oxidative Stress, Blood–Brain Barrier Leakage, and Renal Dysfunction in 5xFAD Mice DOI Open Access
Atcharaporn Ontawong, Geetika Nehra, Bryan Maloney

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4352 - 4352

Published: May 3, 2025

Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) pathology and closely linked to oxidative stress, which contributes blood–brain barrier leakage, renal dysfunction, cognitive decline. We investigated the effects of N-acetyl cysteine (NAC), an FDA-approved antioxidant, on brain Aβ levels, function, cognition in 5xFAD mice. Eight-week-old mice were fed a rodent diet supplemented with 600 mg/kgDiet NAC for 4 weeks; wild-type (WT) control regular diet. detected elevated 4-hydroxynonenal(4-HNE) reduced creatinine clearance, increased plasma S100β levels untreated compared WT controls. Untreated also had higher capillary P-gp activity, impaired WT. treatment Aβ40 normalized 4-HNE improved decreased lowered levels. performance mice, as shown Y-maze. Our findings indicate that Aβ-induced stress impairment, deficits Notably, mitigates these effects, suggesting its potential adjunct therapy AD other Aβ-related pathologies reducing stress.

Language: Английский

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