Fat-rich diet promotes microbiome-dependent ATP synthesis in sheep model DOI Creative Commons
Fan Hu, Kefyalew Gebeyew,

Zhiwu Wu

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: June 4, 2025

Abstract Background The ketogenic diet that forces adenosine triphosphate (ATP) production by beta-oxidation of fatty acids instead carbohydrate glycolysis, has gained consensus on host metabolism. However, the mechanisms how a alters gastrointestinal microbiome and its downstream consequences microbial nutrient availability energy metabolism remain to be elucidated. Here, we used sheep model fed with fat-rich evaluate symbiotic across three regions tract (rumen, ileum, colon) gain comprehensive understanding microbe-mediated ATP biosynthesis. Results showed had greater ADG increased reliance fat oxidation for fuel utilization. Metagenomics analysis loss specialized fiber-degrading bacteria (genus_ Fibrobacter ) in rumen enrichment genera RUG420 Eubacterium , which are involved lipid bile acid processing, ileum. A significant functional shift related was shared microbiomes. These shifts were dominated glycolysis/gluconeogenesis TCA cycle degradation transformation indicating adaptation acquisition. Notably, abundance substrate-level phosphorylation (SLP) enzymes significantly rumen, ileum colon, while ATP-producing capacity through electron transport (ETP) family_Bacteroidaceae Acutalibacteraceae diet. Conclusions Altogether, ATP-related encoding SLP ETP colon contributed 36.95% host’s weight variation. Our study is first one demonstrating potential synthesis under dietary source, providing new perspective precise human macronutrients nutrition.

Language: Английский

Vitamin D: What role in obesity-related cancer? DOI
Pierrick Martinez, William B. Grant

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Fat-rich diet promotes microbiome-dependent ATP synthesis in sheep model DOI Creative Commons
Fan Hu, Kefyalew Gebeyew,

Zhiwu Wu

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: June 4, 2025

Abstract Background The ketogenic diet that forces adenosine triphosphate (ATP) production by beta-oxidation of fatty acids instead carbohydrate glycolysis, has gained consensus on host metabolism. However, the mechanisms how a alters gastrointestinal microbiome and its downstream consequences microbial nutrient availability energy metabolism remain to be elucidated. Here, we used sheep model fed with fat-rich evaluate symbiotic across three regions tract (rumen, ileum, colon) gain comprehensive understanding microbe-mediated ATP biosynthesis. Results showed had greater ADG increased reliance fat oxidation for fuel utilization. Metagenomics analysis loss specialized fiber-degrading bacteria (genus_ Fibrobacter ) in rumen enrichment genera RUG420 Eubacterium , which are involved lipid bile acid processing, ileum. A significant functional shift related was shared microbiomes. These shifts were dominated glycolysis/gluconeogenesis TCA cycle degradation transformation indicating adaptation acquisition. Notably, abundance substrate-level phosphorylation (SLP) enzymes significantly rumen, ileum colon, while ATP-producing capacity through electron transport (ETP) family_Bacteroidaceae Acutalibacteraceae diet. Conclusions Altogether, ATP-related encoding SLP ETP colon contributed 36.95% host’s weight variation. Our study is first one demonstrating potential synthesis under dietary source, providing new perspective precise human macronutrients nutrition.

Language: Английский

Citations

0