Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 654 - 654

Published: Feb. 1, 2025

Epigallocatechin gallate (EGCG), the predominant catechin in green tea, comprises approximately 50% of its total polyphenol content and has garnered widespread recognition for significant therapeutic potential. As principal bioactive component Camellia sinensis, EGCG is celebrated potent antioxidant, anti-inflammatory, cardioprotective, antitumor properties. The bioavailability metabolism within gut microbiota underscore systemic effects, as it absorbed intestine, metabolized into compounds, transported to target organs. This compound been shown influence key physiological pathways, particularly those related lipid inflammation, offering protective effects against a variety diseases. EGCG’s ability modulate cell signaling pathways associated with oxidative stress, apoptosis, immune regulation highlights multifaceted role health promotion. Emerging evidence underscores potential preventing managing range chronic conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, metabolic syndromes. Given growing prevalence lifestyle-related diseases increasing interest natural presents promising avenue novel strategies. review aims summarize current knowledge on EGCG, emphasizing critical versatile agent diverse clinical applications. Further exploration both experimental settings essential fully unlock

Language: Английский

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Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems

BioMed Research International, Journal Year: 2017, Volume and Issue: 2017, P. 1 - 15

Published: Jan. 1, 2017

Nowadays, the society is facing a large health problem with rising of new diseases, including cancer, heart diabetes, neurodegenerative and obesity. Thus, it important to invest in substances that enhance population. In this context, epigallocatechin gallate (EGCG) flavonoid found many plants, especially tea. Several studies support notion EGCG has several benefits fighting obesity, among others. Nevertheless, poor intestinal absorbance instability constitute main drawback use molecule prevention therapy. The encapsulation nanocarriers leads its enhanced stability higher therapeutic effects. A comprehensive review currently available on by means will be addressed.

Language: Английский

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Pecan nuts: A review of reported bioactivities and health effects

Trends in Food Science & Technology, Journal Year: 2017, Volume and Issue: 71, P. 246 - 257

Published: Nov. 7, 2017

Language: Английский

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Phenolic Compounds from Nuts: Extraction, Chemical Profiles, and Bioactivity

Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 68(4), P. 927 - 942

Published: Jan. 7, 2020

Nuts contain a vast array of phenolic compounds having important biological properties. They include substances allocated into the five major groups named acids, flavonoids, tannins, lignans, and stilbene derivatives. The complexity in composition does not allow for setting universal extraction procedure suitable all nut phenolics. use non-conventional techniques, such as those based on microwave, ultrasound, compressed fluids, combined with generally recognized safe solvents is gaining interest. With regard to latter, ethanol, water, ethanol–water mixtures have proven be effective extracting clean, safe, low-cost operations. In recent years, there has been an increasing interest properties natural compounds, especially their role prevention several diseases which oxidative stress reactions are involved. This review provides updated comprehensive overview chemical profiles bioactive

Language: Английский

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Increased global placental DNA methylation levels are associated with gestational diabetes

Clinical Epigenetics, Journal Year: 2016, Volume and Issue: 8(1)

Published: July 25, 2016

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. It known that GDM an altered placental function and changes in gene regulation. More recent studies demonstrated involvement of epigenetic mechanisms. So far, the focus regarding was set on gene-specific DNA methylation analyses. Studies robustly investigated global are lacking. However, several showed tissue-specific alterations independently type 2 diabetes. Thus, aim this study to characterize by measuring 5-methylcytosine (5mC) content examine whether differences GDM. Global quantified current gold standard method, LC-MS/MS. In total, 1030 samples were analyzed single-center birth cohort study. Mothers displayed a significantly increased (3.22 ± 0.63 vs. 3.00 0.46 %; p = 0.013; ±SD). Bivariate logistic regression highly significant positive correlation between presence (p 0.0009). Quintile stratification according 5mC levels revealed frequency evenly distributed quintiles 1–4 (2.9–5.3 %), whereas fifth quintile higher (10.7 0.003). models adjusted for maternal age, BMI, ethnicity, recurrent miscarriages, familiar predisposition clearly independent association hypermethylation Furthermore, ANCOVA model considering predictors substantiated methylation. This first employed robust quantitative assessment over thousand samples. The provides large scale evidence GDM, established risk factors.

Language: Английский

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Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1361 - 1361

Published: June 17, 2019

This article is a comprehensive review of the literature pertaining to antidepressant effects and mechanisms regular tea consumption. Meta-data supplemented with recent observational studies were first analyzed assess association between consumption depression risk. The reported risk ratios (RR) 0.69 95% confidence intervals 0.62–0.77. Next, we thoroughly reviewed human trials, mouse models, in vitro experiments determine predominant underlying observed linear relationship reduced depression. Current theories on neurobiology utilized map tea-mediated activity onto an integrated framework pathology. major nodes within network included hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, inflammation, weakened monoaminergic systems, neurogenesis/neuroplasticity, poor microbiome diversity affecting gut–brain axis. We detailed how each node has subsystems them, including signaling pathways, specific target proteins, or transporters that interface compounds tea, mediating their effects. A pathway was found be ERK/CREB/BDNF pathway, up-regulated by number teasaponin, L-theanine, EGCG combinations catechins metabolites. Black theaflavins are potent anti-inflammatory agents via down-regulation NF-κB signaling. Multiple effective modulators dopaminergic Taken together, our findings show constituents all types, predominantly polyphenols polyphenol metabolites, capable functioning through multiple pathways simultaneously collectively reduce

Language: Английский

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Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

International Journal of Nanomedicine, Journal Year: 2016, Volume and Issue: Volume 11, P. 5645 - 5669

Published: Oct. 1, 2016

Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with high morbidity and mortality worldwide. Chemotherapy recommended to patients intermediate or advanced stage cancer. However, conventional chemotherapy yields low desired response rates due multidrug resistance, fast clearance rate, nonspecific delivery, severe side effects, drug concentration in cells, so on. Nanoparticle-mediated targeted delivery system can surmount aforementioned obstacles through enhanced permeability retention effect active targeting as a novel approach of therapeutics for HCC recent years. The triggered by ligands on system, which recognize internalize into hepatoma cells specificity efficiency. This review focuses latest systems summarizes that enhance capacity targeting, provide some insight future research nanomedicine HCC. Keywords: therapy, hepatocellular carcinoma, ligand, nanoparticle

Language: Английский

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Epigallocatechin-3-gallate protects against diabetic cardiomyopathy through modulating the cardiometabolic risk factors, oxidative stress, inflammation, cell death and fibrosis in streptozotocin-nicotinamide-induced diabetic rats

Biomedicine & Pharmacotherapy, Journal Year: 2017, Volume and Issue: 94, P. 362 - 373

Published: Aug. 1, 2017

Language: Английский

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Composite films based on chitosan and epigallocatechin gallate grafted chitosan: Characterization, antioxidant and antimicrobial activities

Food Hydrocolloids, Journal Year: 2020, Volume and Issue: 111, P. 106384 - 106384

Published: Oct. 6, 2020

Language: Английский

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Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 133, P. 110975 - 110975

Published: Nov. 16, 2020

Diabetes mellitus (type 1 and type 2) its various complications continue to place a huge burden on global medical resources, despite the availability of numerous drugs that successfully lower blood glucose levels. The major challenging issue in diabetes management is prevention remain leading cause diabetes-related mortality. Moreover, limited long-term durability monotherapy undesirable side effects currently used anti-diabetic underlie urgent need for novel therapeutic approaches. Phytochemicals represent rich source plant-derived molecules are pivotal importance identification compounds with potential. In this review, we aim discuss recent advances large array phytochemicals immense potential complications. Given metabolic inflammation has been established as key pathophysiological event drives progression diabetes, focus protective representative inflammation. This paper also discusses development new target

Language: Английский

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