In Vitro Antioxidant, Antithrombotic and Anti-Inflammatory Properties of the Amphiphilic Bioactives from Greek Organic Starking Apple Juice and Its By-Products (Apple Pomace)

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 2807 - 2807

Published: March 5, 2025

The anti-inflammatory, antithrombotic and antioxidant effects of extracts from both apple juice by-products (apple pomace) organic cultured Greek Starking apples were evaluated in vitro. All separated their total amphiphilic compounds (TACs) lipophilic (TLCs) assessed for phenolic content (TPC), carotenoid (TCC) activities (by the DPPH, ABTS FRAP assays), as well anti-inflammatory potency against thrombo-inflammatory mediator, platelet activating factor (PAF) a standard platelet-agonist (ADP) human platelets. rich-in-TAC showed much higher phenolics carotenoids than TLC extracts, which was also reflected by stronger capacities observed TAC. ATR-FTIR spectroscopy revealed presence not only but polar lipids (PLs) TAC, structural analysis with LC–MS further fatty acid composition favorable unsaturated acids (UFAs) versus saturated ones (SFAs). such bioactive PLs that are rich UFA within TAC pomace provide an explanation potent properties these mainly inflammatory pathway PAF aggregation induced ADP. Overall, results support antioxidant, potential especially by-products, can be utilized sustainable ingredients several functional products circular economy design.

Language: Английский

Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive

Language: Английский

Rice Bran Consumption Improves Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 114 - 114

Published: Dec. 30, 2024

Dyslipidemia, a leading risk factor for cardiovascular diseases (CVDs), significantly contributes to global morbidity and mortality. Rice bran, rich in bioactive compounds such as γ-oryzanol tocotrienols, has demonstrated promising lipid-modulating effects. This meta-analysis aimed evaluate the effects of rice bran on lipid profiles, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), identify factors influencing its efficacy across different populations intervention conditions. A systematic search PubMed, Web Science, Scopus was conducted randomized controlled trials (RCTs) published up November 2024. Effect sizes were calculated mean differences with 95% confidence intervals (CIs). Subgroup analyses performed based form, dosage, duration, region, participant characteristics. Heterogeneity estimated by Eleven RCTs involving 572 participants met inclusion criteria. Pooled results showed that consumption reduced TG (-15.13 mg/dL; CI: -29.56, -0.71), TC (-11.80 -19.35, -4.25), LDL-C (-15.11 -24.56, -5.66) moderate heterogeneity ( especially form oil, improves supporting role functional food CVD prevention. Future research should focus long-term studies diverse confirm explore underlying mechanisms.

Language: Английский