Synergistic Antibacterial Activity of Green Synthesized Silver Nanomaterials with Colistin Antibiotic against Multidrug-Resistant Bacterial Pathogens DOI Creative Commons
Mohamed Taha Yassin, Ashraf Abdel‐Fattah Mostafa, Abdulaziz A. Al–Askar

et al.

Crystals, Journal Year: 2022, Volume and Issue: 12(8), P. 1057 - 1057

Published: July 29, 2022

The high frequency of nosocomial bacterial infections caused by multidrug-resistant pathogens contributes to significant morbidity and mortality worldwide. As a result, finding effective antibacterial agents is critical importance. Hence, the aim present study was greenly synthesize silver nanoparticles (AgNPs) utilizing Salvia officinalis aqueous leaf extract. biogenic AgNPs were characterized different physicochemical techniques such as energy-dispersive X-ray spectroscopy (EDX), ultraviolet-visible spectrophotometry (UV-Vis), diffraction analysis (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) analysis. Additionally, synergistic antimicrobial effectiveness biosynthesized with colistin antibiotic against strains evaluated standard disk diffusion assay. bioformulated revealed features, small particle size 17.615 ± 1.24 nm net zeta potential value −16.2 mV. elemental mapping that main element, recording relative mass percent 83.16%, followed carbon (9.51%), oxygen (5.80%), silicon (0.87%), chloride (0.67%). disc assay showed potency tested pathogens, highest efficiency Escherichia coli strain an inhibitory zone diameter 37.86 0.21 mm at concentration 100 µg/disk. In addition, activity significantly higher than (p ≤ 0.05) multidrug resistant namely, Acinetobacter baumannii. antibiotic, demonstrating A. baumannii (85.57%) Enterobacter cloacae (53.63%), E. (35.76%), Klebsiella pneumoniae (35.19%), Salmonella typhimurium (33.06%), Pseudomonas aeruginosa (13.75%). conclusion, unique characteristics activities pathogens. Consequently, potent effect AgNPs–colistin combination highlights this for fabrication highly coatings in intensive care units successful control spread infections.

Language: Английский

Research progress on antibacterial applications of metal-organic frameworks and their biomacromolecule composites DOI

Lei Guo,

Wei Kong,

Yilin Che

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129799 - 129799

Published: Feb. 1, 2024

Language: Английский

Citations

18
Global status of antimicrobial resistance in clinical Enterococcus faecalis isolates: systematic review and meta-analysis DOI Creative Commons

Lingbo Guan,

Masoumeh Beig, Lina Wang

et al.

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 24, 2024

Due to the increasing emergence of antibiotic resistance in Enterococcus faecalis (E. faecalis), it indicated as potentially opportunistic pathogen causing various healthcare-associated and life-threatening diseases around world. The aim this meta-analysis was evaluate weighted pooled rates clinical E. isolates based on over time, areas, antimicrobial susceptibility testing (AST), infection source. We searched studies PubMed, Scopus, Web Science (November 30, 2022). All statistical analyses were carried out using package R. analysis encompassed a total 74 conducted 28 countries. According meta-regression, chloramphenicol, fosfomycin, imipenem, linezolid, minocycline, norfloxacin, quinupristin-dalfopristin, tetracycline rate increased time. Analysis revealed statistically significant differences for ampicillin, erythromycin, gentamicin, penicillin, rifampicin, teicoplanin, tetracycline, vancomycin across Globally, prevalence drug resistant strains are increase Daptomycin tigecycline can be an effective agent treatment infections. Considering low continents Europe Australia, is suggested take advantage their preventive strategies order obtain efficient results other places with high resistance.

Language: Английский

Citations

17
A Foundation Model Identifies Broad-Spectrum Antimicrobial Peptides against Drug-Resistant Bacterial Infection DOI Creative Commons
Tingting Li,

Xuanbai Ren,

Xiaoli Luo

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 30, 2024

Development of potent and broad-spectrum antimicrobial peptides (AMPs) could help overcome the resistance crisis. We develop a peptide language-based deep generative framework (deepAMP) for identifying potent, AMPs. Using deepAMP to reduce enhance membrane-disrupting abilities AMPs, we identify, synthesize, experimentally test 18 T1-AMP (Tier 1) 11 T2-AMP 2) candidates in two-round design by employing cross-optimization-validation. More than 90% designed AMPs show better inhibition penetratin both Gram-positive (i.e., S. aureus) Gram-negative bacteria K. pneumoniae P. aeruginosa). T2-9 shows strongest antibacterial activity, comparable FDA-approved antibiotics. that three (T1-2, T1-5 T2-10) significantly aureus compared ciprofloxacin are effective against skin wound infection female mouse model infected with aeruginosa. In summary, expedites discovery effective, drug-resistant bacteria.

Language: Английский

Citations

17
A Study of the Synergistic Effects of Essential Oils from Origanum compactum and Origanum elongatum with Commercial Antibiotics against Highly Prioritized Multidrug-Resistant Bacteria for the World Health Organization DOI Creative Commons
Aziz Drioiche, Soukayna Baammi, Khalid Zibouh

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 210 - 210

Published: April 7, 2024

The irrational use of antibiotics has favored the emergence resistant bacteria, posing a serious threat to global health. To counteract antibiotic resistance, this research seeks identify novel antimicrobials derived from essential oils that operate through several mechanisms. It aims evaluate quality and composition Origanum compactum elongatum; test their antimicrobial activity against various strains; explore synergies with commercial antibiotics; predict efficacy, toxicity, stability compounds; understand molecular interactions docking dynamic simulations. were extracted via hydrodistillation flowering tops oregano in Middle Atlas Mountains Morocco. Gas chromatography combined mass spectrometry (GC-MS) was used examine composition. Nine common chosen tested alone or combination discover synergistic effects clinically important bacterial strains. A comprehensive silico study conducted, involving dynamics simulations (MD). O. elongatum oil includes borneol (8.58%), p-cymene (42.56%), thymol (28.43%), carvacrol (30.89%), whereas is mostly composed γ-terpinene (22.89%), (15.84%), (10.21%), (E)-caryophyllene (3.63%). With proving be most potent, these showed antibacterial action both Gram-positive Gram-negative bacteria. Certain antibiotics, including ciprofloxacin, ceftriaxone, amoxicillin, ampicillin, have been shown elicit effects. fight elongatum, particularly those high (E)-caryophyllene, seem promising when antibiotics. These could result ability target same proteins facilitate access sites, as suggested by Molecular validated examined protein–ligand complexes, emphasizing propensity substances like for particular proteins, opening door potentially effective new therapeutic approaches pathogens multiple drugs.

Language: Английский

Citations

16
From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota DOI Creative Commons
Hamed Tahmasebi,

Neda Arjmand,

Marzieh Monemi

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 93 - 93

Published: Jan. 9, 2025

The growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse overuse led to emergence resistant bacterial strains. Key resistance mechanisms include genetic mutations, horizontal gene transfer, biofilm formation, with microbiota acting as reservoir for antibiotic genes (ARGs). Industrialization environmental factors exacerbated this issue, contributing rise in infections multidrug-resistant (MDR) bacteria, such methicillin-resistant Staphylococcus aureus (MRSA) carbapenem-resistant Enterobacteriaceae. These pathogens compromise effectiveness essential treatments like surgical prophylaxis chemotherapy, increase healthcare costs, prolong hospital stays. This crisis highlights need One-Health approach, particularly regions weak regulatory frameworks. Innovative strategies, including next-generation sequencing (NGS) technologies, offer promising avenues mitigating resistance. Addressing challenge requires coordinated efforts, encompassing research, policymaking, public education, stewardship, safeguard current foster development new therapeutic solutions. An integrated, multidimensional strategy is tackle escalating problem ensure sustainability effective antimicrobial treatments.

Language: Английский

Citations

5
The role of bacterial metabolism in antimicrobial resistance DOI
Mehrose Ahmad, Sai Varun Aduru, Robert P. Smith

et al.

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

4
Unseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens DOI Creative Commons

Giedrė Valdonė Sakalauskienė,

Lina Malcienė, Edgaras Stankevıčıus

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 63 - 63

Published: Jan. 9, 2025

Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by particularly concerning gram-negative Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens. Designated as "priority" 2017, these bacteria continue to pose significant threat 2024, during worldwide SARS-CoV-2 pandemic, where coinfections with ESKAPE members contributed worsened patient outcomes. The declining effectiveness current treatments against pathogens has led an increased disease burden increase mortality rates globally. This review explores sophisticated mechanisms driving AMR bacteria, focusing on Key bacterial contributing include limitations drug uptake, production antibiotic-degrading enzymes, alterations target sites, enhanced efflux systems. Comprehending pathways is vital for formulating innovative therapeutic strategies tackling ongoing posed resistant

Language: Английский

Citations

2
New quinazolone–sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations DOI Creative Commons
Asmaa F. Kassem,

Sherif S. Ragab,

Mohamed A. Omar

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(2), P. 1033 - 1048

Published: Jan. 1, 2025

A new series of quinazolinone–alkanesulfonates have been designed and synthesized as antimicrobial agents. Two derivatives exhibited potential MIC activity.

Language: Английский

Citations

2
Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh DOI Creative Commons
Spencer Mark Mondol,

Mohammad Ali Hossain,

Fahim Kabir Monjurul Haque

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 18, 2025

Language: Английский

Citations

2
Rosaceae Honey: Antimicrobial Activity and Prebiotic Properties DOI Creative Commons
Francesca Coppola, Manar Abdalrazeq, Florinda Fratianni

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 298 - 298

Published: March 13, 2025

Background: Flowering members of the globally diffused Rosaceae family include popular plants, such as apple, almond, and cherry, which play a fundamental role honeybee nectariferous polleniferous agents. Through production honey, these plants can also an indirect in prevention treatment many diseases, including infections, fighting occurrence resistant microorganisms, concurrently stimulating growth beneficial bacteria. Objectives: This study focused on effect some plants’ hawthorn, raspberry, against pathogens Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus. Results: Results demonstrated honey’s ability to impair swimming motility. A crystal violet test indicated that honey could inhibit formation stabilization biofilms, with inhibition rates up 59.43% for immature biofilms (showed by apple A. baumannii) 39.95% sessile bacterial cells mature (when we used cherry S. aureus). In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, were most effective inhibiting cell metabolism both (56.47% vs. K. pneumoniae) (54.36% baumannii). Honey stimulated Lactobacillus bulgaricus, Lacticaseibacillus casei Shirota, gasseri, plantarum, rhamnosus; almond significantly increased vitro adhesion capacity L. bulgaricus Shirota. Tests probiotic supernatants biofilm pathogens. Conclusions: Our results encourage further studies assess potential application food preservation health field, it fight antimicrobial resistance clinical pathogens, potentially enhance host’s gut wellness. The use nanotechnological biotechnological approaches be suggested too.

Language: Английский

Citations

2