Seroprevalence of dengue, yellow fever, and related flaviviruses among the rural human population in Nguruman and Kerio Valley, Kenya DOI Creative Commons

Mercy Hokah Kibathi,

Edith Chepkorir,

Sepha Nyatichi Mabeya

et al.

Frontiers in Virology, Journal Year: 2024, Volume and Issue: 4

Published: Sept. 24, 2024

Background Yellow fever virus (YFV) and dengue (DENV) are among the major re-emerging arboviruses that pose a significant threat to public health. Their associated burden prevalence can be substantially underestimated due insufficient surveillance inadequate diagnosis. This study aimed determine evidence of dengue, yellow related flaviviruses circulation rural human populations residing in Nguruman (Kajiado County) Kerio Valley (Baringo County), two dryland ecosystems Kenyan Rift Valley. Methods Serum samples obtained from febrile patients between 5 85 years through hospital-based cross-sectional survey July 2020 – May 2023, were screened for neutralizing antibodies YFV, DENV-2 flaviviruses, West Nile (WNV) Zika (ZIKV) via Plaque reduction neutralization test (PRNT). The sites important demographic characteristics using structural questionnaire data analyzed seroprevalence compared. A multinomial logistic regression model was done predict risk each most prevalent viruses with covariates; age, gender, occupation. Results Overall, 54.5% (50.1–59.0% 95% confidence interval (CI) tested positive at least one four Flaviviruses. percentage significantly higher (64.34%, 184/286) than (40.2%, 78/194) (P<0.0001). YFV had highest prevalence, followed by WNV (16.25%), ZIKV (5.2%), (1%). (51%) (6%) (P<0.0001), while observed only low seropositivity 2%. In contrast Nguruman, where rates males 47.47% (P=0.049), Valley, females showed considerably viral 60.82% (P<0001). Conclusion suggests there is Flaviviruses both regions, posing health risk, could potentially contribute clinical disease. However, vary specific site. Furthermore, WNV, transmission DENV specifically noted Nguruman. findings inform direct cost-effective actions (such as YF vaccines) precise vector improved disease prediction.

Language: Английский

Seroprevalence of dengue, yellow fever, and related flaviviruses among the rural human population in Nguruman and Kerio Valley, Kenya DOI Creative Commons

Mercy Hokah Kibathi,

Edith Chepkorir,

Sepha Nyatichi Mabeya

et al.

Frontiers in Virology, Journal Year: 2024, Volume and Issue: 4

Published: Sept. 24, 2024

Background Yellow fever virus (YFV) and dengue (DENV) are among the major re-emerging arboviruses that pose a significant threat to public health. Their associated burden prevalence can be substantially underestimated due insufficient surveillance inadequate diagnosis. This study aimed determine evidence of dengue, yellow related flaviviruses circulation rural human populations residing in Nguruman (Kajiado County) Kerio Valley (Baringo County), two dryland ecosystems Kenyan Rift Valley. Methods Serum samples obtained from febrile patients between 5 85 years through hospital-based cross-sectional survey July 2020 – May 2023, were screened for neutralizing antibodies YFV, DENV-2 flaviviruses, West Nile (WNV) Zika (ZIKV) via Plaque reduction neutralization test (PRNT). The sites important demographic characteristics using structural questionnaire data analyzed seroprevalence compared. A multinomial logistic regression model was done predict risk each most prevalent viruses with covariates; age, gender, occupation. Results Overall, 54.5% (50.1–59.0% 95% confidence interval (CI) tested positive at least one four Flaviviruses. percentage significantly higher (64.34%, 184/286) than (40.2%, 78/194) (P<0.0001). YFV had highest prevalence, followed by WNV (16.25%), ZIKV (5.2%), (1%). (51%) (6%) (P<0.0001), while observed only low seropositivity 2%. In contrast Nguruman, where rates males 47.47% (P=0.049), Valley, females showed considerably viral 60.82% (P<0001). Conclusion suggests there is Flaviviruses both regions, posing health risk, could potentially contribute clinical disease. However, vary specific site. Furthermore, WNV, transmission DENV specifically noted Nguruman. findings inform direct cost-effective actions (such as YF vaccines) precise vector improved disease prediction.

Language: Английский

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