Gene, Journal Year: 2024, Volume and Issue: 939, P. 149181 - 149181
Published: Dec. 19, 2024
Language: Английский
MARKHOR (The Journal of Zoology), Journal Year: 2025, Volume and Issue: unknown, P. 10 - 18
Published: March 31, 2025
Antimicrobial resistance (AMR) is a critical health challenge worldwide, that arises when bacteria, viruses, fungi, and parasites become resistant to antimicrobial medications, making diseases more challenging treat. The enzymatic breakdown of antibiotics, modifications target locations, elevated efflux pumps, changes in cell membrane permeability are some the processes behind AMR. A key factor development transmission AMR has been unregulated use livestock feed for preventive purposes. Rapid global expansion antibiotic-resistant bacteria posing hidden pandemic risk public demanding immediate action. misuse unnecessary overreliance on antibiotics human medicine one many contributing factors AMR, veterinary practices, agriculture, as well inadequate infection prevention strategies, lack diagnostic tools, sanitation. Preventive measures against involve promoting rational through stewardship, improving control advancing rapid technologies, reducing antibiotic food production, increasing awareness. Efforts must also focus collaboration monitor trends, enhance regulatory frameworks, invest research develop novel agents alternative therapies. Addressing requires an interdisciplinary coordinated approach safeguard efficacy current treatments reduce occurrence resistance.
Language: Английский
Citations
0
Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 677 - 677
Published: July 21, 2024
The rapid spread of carbapenemase-producing strains has led to increased levels resistance among Gram-negative bacteria, especially enterobacteria. current study aimed collect and genetically characterize the colistin- carbapenem-resistant isolates, obtained in one biggest hospitals (Military Medical Academy) Sofia, Bulgaria. Clonal relatedness was detected by RAPD MLST. Carbapenemases, ESBLs,
Language: Английский
Citations
3
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 27, 2024
Abstract Pseudomonas aeruginosa is a significant opportunistic pathogen, and its complex mechanisms of antibiotic resistance pose challenge to modern medicine. This literature review explores the advancements made from 1979 2024 in understanding regulatory networks genes , with particular focus on molecular underpinnings these mechanisms. The highlights four main pathways involved drug resistance: reducing outer membrane permeability, enhancing active efflux systems, producing antibiotic-inactivating enzymes, forming biofilms. These are intricately regulated by combination genetic regulation, transcriptional regulators, two-component signal transduction, DNA methylation, small RNA molecules. Through an in-depth analysis synthesis existing literature, we identify key elements mexT ampR argR as potential targets for novel antimicrobial strategies. A profound core control nodes offers new perspective therapeutic intervention, suggesting that modulating could potentially reverse restore bacterial susceptibility antibiotics. looks forward future research directions, proposing use gene editing systems biology further understand develop effective strategies against . expected provide innovative solutions problem infectious diseases.
Language: Английский
Citations
3
Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(12), P. 7347 - 7354
Published: April 23, 2024
Klebsiella pneumoniae species complex (KpSC) is an important disseminator of carbapenemase-encoding genes, mainly bla
Language: Английский
Citations
2
Journal of Global Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 38, P. 205 - 211
Published: June 5, 2024
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a serious threat to public health. Globally, carbapenemases-producing CRPA isolates mainly belong 'high-risk' clones; however, the molecular epidemiology of circulating in Chile are scarce, where this pathogen main aetiological agent ventilator-associated pneumonia. To characterize phylogenomics and features ST654 collected between 2016 - 2022. 89 different Chilean hospitals from clinical specimens 2005 2022 were analyzed. Antibiotic susceptibility tests carbapenemases production carried out on isolates. Also, they subjected whole-genome sequencing (WGS) which silico analyses performed. Thirty-four strains (38.2%) belonged 'high risk' clone, being most predominant lineage collection. Most these sub-clade including KPC-producers that also clustered with Argentina USA, whereas few VIM NDM co-producers two smaller sub-clades. The exhibited broad resistome encompassing genes mediating resistance several other clinically relevant drugs. Additionally, all 34 ExoS+ as virulence factor associated O4-serotype. Our report represents comprehensive phylogenomic study clone date. suggest undergoing divergent evolutionary path Chile, since O4-serotype, differing previous descriptions, underline relevance performing surveillance pathogen.
Language: Английский
Citations
1
BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)
Published: Oct. 1, 2024
Language: Английский
Citations
1
Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1029 - 1029
Published: Oct. 31, 2024
The increase in antimicrobial resistance includes emerging mechanisms such as 16S ribosomal RNA methylases, which confer high-level to aminoglycosides. In this regard, the most predominant genes observed worldwide are
Language: Английский
Citations
0
Gene, Journal Year: 2024, Volume and Issue: 939, P. 149181 - 149181
Published: Dec. 19, 2024
Language: Английский
Citations
0