Secreted Metabolites from Pseudomonas, Staphylococcus, and Borrelia Biofilm: Modulation of Immunogenicity by a Nutraceutical Enzyme and Botanical Blend DOI Creative Commons
Dina Cruickshank,

Debby E. Hamilton,

Ifeanyi Iloba

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 991 - 991

Published: May 15, 2024

Bacterial biofilms are hardy, adaptable colonies, evading immune recognition while triggering and sustaining inflammation. The goals for this study were to present a method testing the immunogenicity of secreted metabolites from pathogenic biofilm document whether treated with nutraceutical enzyme botanical blend (NEBB) showed evidence reprogrammed bacterial metabolism, potentially becoming more recognizable system. We screened immune-modulating properties established Pseudomonas aeruginosa (Pa), Stapholycoccus simulans (Ss), Borrelia burgdorferi (Bb). Secreted significantly increased cytokine production by human peripheral blood mononuclear cells, including Interleukin-1-beta (IL-1β), Interleukin-6 (IL-6), macrophage inflammatory protein-1-alpha (MIP-1α), tumor necrosis factor-alpha (TNF-α), interleukin-1 receptor antagonist (IL-1ra), interleukin-10 (IL-10). Pa triggered most robust increase in IL-1β, whereas Bb IL-10. NEBB-disrupted produced altered modulation compared untreated biofilm. Metabolites MIP-1α levels reduced IL-10 levels, suggesting ability suppress recruitment phagocytes results suggest that disruption offers strategies inflammation management chronic infectious illnesses. Further clinical studies warranted evaluate correlations infected hosts.

Language: Английский

Towards shortening the duration of antibiotic therapy for Lyme borreliosis: a systematic review and meta-analysis DOI
A. Raffetin, Anna J. Henningsson,

Katharina Ornstein

et al.

Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Secreted Metabolites from Pseudomonas, Staphylococcus, and Borrelia Biofilm: Modulation of Immunogenicity by a Nutraceutical Enzyme and Botanical Blend DOI Creative Commons
Dina Cruickshank,

Debby E. Hamilton,

Ifeanyi Iloba

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 991 - 991

Published: May 15, 2024

Bacterial biofilms are hardy, adaptable colonies, evading immune recognition while triggering and sustaining inflammation. The goals for this study were to present a method testing the immunogenicity of secreted metabolites from pathogenic biofilm document whether treated with nutraceutical enzyme botanical blend (NEBB) showed evidence reprogrammed bacterial metabolism, potentially becoming more recognizable system. We screened immune-modulating properties established Pseudomonas aeruginosa (Pa), Stapholycoccus simulans (Ss), Borrelia burgdorferi (Bb). Secreted significantly increased cytokine production by human peripheral blood mononuclear cells, including Interleukin-1-beta (IL-1β), Interleukin-6 (IL-6), macrophage inflammatory protein-1-alpha (MIP-1α), tumor necrosis factor-alpha (TNF-α), interleukin-1 receptor antagonist (IL-1ra), interleukin-10 (IL-10). Pa triggered most robust increase in IL-1β, whereas Bb IL-10. NEBB-disrupted produced altered modulation compared untreated biofilm. Metabolites MIP-1α levels reduced IL-10 levels, suggesting ability suppress recruitment phagocytes results suggest that disruption offers strategies inflammation management chronic infectious illnesses. Further clinical studies warranted evaluate correlations infected hosts.

Language: Английский

Citations

1