Oral Biofilm and Its Connection to Alzheimer’s Disease DOI Open Access
Gregori M Kurtzman, Robert Horowitz, Richard J. Johnson

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Dementia and Alzheimer's disease are common occurrences in the population, affecting many patients. Recent research studies have found a link between oral biofilm initiation of these conditions or worsening their presentation. Periodontal associated with its bacteria often not considered by medical community when treating Coordination therapy dentist can improve patient's health. Decreasing allows physician to provide coordinated total healthcare. Emphasis education patient on importance maintaining good homecare routine dental recall prophylaxis appointments systemic health limit progression mental conditions. This article discusses connection health, specifically disease, how those through

Language: Английский

Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives DOI

Simone Lista,

Antonio Munafò, Filippo Caraci

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102659 - 102659

Published: Jan. 10, 2025

Language: Английский

Citations

2
Balancing the Oral–Gut–Brain Axis with Diet DOI Open Access
Rebecca Kerstens, Yong Zhi Ng, Sven Pettersson

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3206 - 3206

Published: Sept. 22, 2024

Background: The oral microbiota is the second largest microbial community in humans. It contributes considerably to diversity and health effects, much like gut microbiota. Despite physical chemical barriers separating cavity from gastrointestinal tract, bidirectional transmission occurs between two regions, influencing overall host health. Method: This review explores intricate interplay of oral–gut–brain axis, highlighting pivotal role systemic ageing, how it can be influenced by diet. Results: Recent research suggests a relationship diseases, such as periodontitis, problems, broader significance oral–gut axis well neurological disorders mental Diet influences gut. While certain diets/dietary components improve both health, others, fermentable carbohydrates, promote pathogens while boosting Conclusions: Understanding these dynamics key for promoting healthy through dietary interventions that support mitigate age-related risks.

Language: Английский

Citations

3
Gut microbiome-immune interactions and their role in rheumatoid arthritis development DOI Creative Commons
Madiyar Nurgaziyev, Argul Issilbayeva, R. I. Bersimbaev

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17477 - e17477

Published: July 11, 2024

Objective The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on development rheumatoid arthritis. Methods This was performed in Astana, Kazakhstan, included 77 Kazakh female patients older than 18 years, who met American College Rheumatology 2010 classification criteria for arthritis (RA), 113 healthy controls. DNA extracted from fecal samples obtained all participants subsequent sequencing at 16S rRNA gene V1-V3 locus, facilitating analysis microbiome. Multiplex immunoassay employed measure concentrations inflammatory cytokines, chemokines, immunoglobulins both plasma samples. Results Our taxonomic revealed significant differences composition between control cohort RA. Alpha diversity significantly lower RA group. Lachnospiraceae were most abundant taxon found be crucial, showing correlations such as IL5. Additionally, Oscillospiraceae exhibited predictable power distinguished groups. Conclusion identifies key microbiome patients, revealing distinct microbial patterns specific taxa abundance. We highlight potential biomarkers bacterial pathways, offering insights into indicating possibilities personalized treatment.

Language: Английский

Citations

1
Dependencia funcional y salud oral en adultos mayores: un estudio transversal con oficiales de policía retirados DOI Creative Commons

Evelyn Del Socorro Auqui-Saavedra,

Katherin Jhosely Barzola-Rafael,

Luis Alexander Orrego-Ferreyros

et al.

Atención Primaria, Journal Year: 2024, Volume and Issue: 56(9), P. 102962 - 102962

Published: May 29, 2024

Citations

0
Oral Microbiota in Patients with Alzheimer’s Disease: A Systematic Review DOI Creative Commons
Sanne M. Pruntel,

Lauren A. Leusenkamp,

Egija Zaura

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8869 - 8869

Published: Oct. 2, 2024

Oral microorganisms have been found in the cerebral milieu, suggesting involvement of oral microbiota onset and course Alzheimer’s Disease (AD) through mechanisms such as amyloid-beta accumulation, tau phosphorylation neuroinflammation. It is still uncertain whether which bacteria are associated with AD. Therefore, aim this systematic review was to assess current evidence for associations between A database search Pubmed Embase resulted 623 hits. After removing duplicates, 437 papers remained. Of these, 13 passed inclusion criteria were included quality/risk bias assessment data extraction. Analysis these studies revealed high heterogeneity terms sample size, age, study design microbiological methods. Quality using MINORS indicated reasonable good quality across studies. As a result omission two criteria, results may biased. There no conclusive if AD since many conflicting reported. Although overall acceptable, differed protocol. Further research needed clarify association.

Language: Английский

Citations

0
Oral Biofilm and Its Connection to Alzheimer’s Disease DOI Open Access
Gregori M Kurtzman, Robert Horowitz, Richard J. Johnson

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Dementia and Alzheimer's disease are common occurrences in the population, affecting many patients. Recent research studies have found a link between oral biofilm initiation of these conditions or worsening their presentation. Periodontal associated with its bacteria often not considered by medical community when treating Coordination therapy dentist can improve patient's health. Decreasing allows physician to provide coordinated total healthcare. Emphasis education patient on importance maintaining good homecare routine dental recall prophylaxis appointments systemic health limit progression mental conditions. This article discusses connection health, specifically disease, how those through

Language: Английский

Citations

0