The Omicron Variant Is Associated with a Reduced Risk of the Post COVID-19 Condition and Its Main Phenotypes Compared to the Wild-Type Virus: Results from the EuCARE-POSTCOVID-19 Study DOI Creative Commons
Francesca Bai, Andrea Santoro, Pontus Hedberg

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1500 - 1500

Published: Sept. 23, 2024

Post COVID-19 condition (PCC) is defined as ongoing symptoms at ≥1 month after acute COVID-19. We investigated the risk of PCC in an international cohort according to viral variants. included 7699 hospitalized patients six centers (January 2020-June 2023); a subset participants with visit over year clinical recovery were analyzed. Variants observed or estimated using Global Data Science Initiative (GISAID) data. Because returning for post may have higher risk, and because variant could be associated probability returning, we used weighted logistic regressions. proportion effect wild-type (WT) virus vs. Omicron on PCC, which was mediated by Intensive Care Unit (ICU) admission, through mediation analysis. In total, 1317 returned COVID median 2.6 (IQR 1.84-3.97) months recovery. WT present 69.6% participants, followed Alpha (14.4%), Delta (8.9%), Gamma (3.9%) strains (3.3%). Among most common manifestations fatigue (51.7%), brain fog (32.7%) respiratory (37.2%). reduced clusters; conversely, variants WT. 42% appeared ICU admission. A infection, suggesting possible reduction burden time. non-negligible seems increased disease severity during disease.

Language: Английский

Risk of long covid in patients with pre-existing chronic respiratory diseases: a systematic review and meta-analysis DOI Creative Commons
Paul Terry, R. Eric Heidel, Alexandria Quesenberry

et al.

BMJ Open Respiratory Research, Journal Year: 2025, Volume and Issue: 12(1), P. e002528 - e002528

Published: Jan. 1, 2025

Background An estimated 10–30% of people with COVID-19 experience debilitating long-term symptoms or long covid. Underlying health conditions associated chronic inflammation may increase the risk Methods We conducted a systematic review and meta-analysis to examine whether covid was altered by pre-existing asthma obstructive pulmonary disease (COPD) in adults. identified studies searching PubMed Embase databases from inception 13 September 2024. excluded that focused on children defined only terms respiratory symptoms. used random-effects, restricted maximum likelihood models analyse data pooled 51 studies, which included 43 analyses 30 COPD. The bias assessed using ROBINS-E table. Results found 41% increased odds (95% CI 1.29 1.54); COPD 32% 1.16 1.51). Pre-existing asthma, but not COPD, covid-associated fatigue. observed heterogeneity results related hospitalisation status. Potential confounding inconsistent measurement exposure outcome variables were among limitations. Conclusions Our findings support hypothesis covid, including fatigue outcomes patients asthma. Because targets tract, these inflammatory lower tract could provide mechanistic clues common pathway for development sequelae

Language: Английский

Citations

2
Long COVID across SARS‐CoV‐2 variants: Clinical features, pathogenesis, and future directions DOI Creative Commons
Laurence S. C. Lok,

Shuvam Sarkar,

Chi‐Ming Lam

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Long coronavirus disease (COVID) is characterized by persistent symptoms following severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection and has emerged as a significant health concern. As SARS‐CoV‐2 evolved from the wild‐type strain to Alpha, Beta, Delta, Omicron variants, there may be variant‐specific influence on long COVID akin disease. This review aims summarize our current knowledge of influences in incidence, symptom profile well mechanisms pathogenesis. We highlight that incidence lower with variants. The also show some dependence different reduction cardiopulmonary more recent heterogeneity related differences affecting immune system, viral persistence, autoimmunity. However, emerging data suggest vaccinations play big role shaping presentation COVID. ongoing work profiles populations infected only will beneficial toward useful definitions development effective diagnostic therapeutic strategies.

Language: Английский

Citations

4
Analysis of risk factors for long COVID after mild COVID-19 during the Omicron wave in Japan DOI

Hotaka Namie,

Takahiro Takazono,

Rina Kawasaki

et al.

Respiratory Investigation, Journal Year: 2025, Volume and Issue: 63(3), P. 303 - 310

Published: March 5, 2025

Language: Английский

Citations

0
Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review DOI Creative Commons
Abby E. Rudolph,

Nadine Al Akoury,

Natalija Bogdanenko

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 13, 2025

This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for relationship between COVID-19 vaccination Post-COVID-19 Condition (PCC) by timing relative to infection or PCC-onset. Comparisons vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) study characteristics known impact burden VE other endpoints were possible 31 studies where preceded infection. Seventy-seven percent pre-infection aVE statistically significant (range: 7%–95%). Statistically slightly higher mRNA 14%–84%) than non-mRNA vaccines 16%–38%) ranges before during Omicron overlapped. Our findings suggest SARS-CoV-2 reduces risk regardless type, number doses received, definition, predominant variant, severity acute infections included.

Language: Английский

Citations

0
Cardiac symptoms in patients 3–6 months after contracting COVID-19– data from the polish STOP-COVID registry DOI Creative Commons
Mateusz Babicki, Joanna Kapusta, Damian Kołat

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Abstract Background Common complaints of long COVID patients are cardiac symptoms such as fatigue, weakness, and a feeling palpitations. The study aimed to investigate the clinical features with persistent cardiological occurring within 3 6 months after COVID-19. Differences in ambulatory blood pressure monitoring (ABPM), Holter ECG (electrocardiogram) Echocardiography between people without were evaluated. We also assessed whether anxiety depression may be implicated outcomes. Materials methods This was retrospective affiliated STOP-COVID registry who attended follow-up visit 3–6 undergoing present performed tests: ABPM, Echocardiography. 504 additionally had GAD-2 (Generalized Anxiety Disorder 2-item) PHQ-2 (Patient Health Questionnaire-2) tests performed. Results analysis included 1080 patients. At least 1 analyzed 586 (54.3%). most common symptom fatigue (38.9%). Comparing or palpitations showed that mean value ventricular extrasystole higher former group ( p = 0.011). symptoms, there differences values 0.022) < 0.001) scales, well percentage responses related risk depression. Conclusion Cardiological among health issues must face contracting People more excessive extrasystoles than these symptoms. Trial registration Our based on medical data COVID-19 treated out-patient basis Polish Long-Covid Cardiovascular (PoLoCOV-CVD) (ClinicalTrials.gov identifier– NCT05018052, date 29.05.2020). Consent conduct obtained from Bioethics Committee District Medical Chamber Lodz (no. KB-0115/2021).

Language: Английский

Citations

0
The Omicron Variant Is Associated with a Reduced Risk of the Post COVID-19 Condition and Its Main Phenotypes Compared to the Wild-Type Virus: Results from the EuCARE-POSTCOVID-19 Study DOI Creative Commons
Francesca Bai, Andrea Santoro, Pontus Hedberg

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1500 - 1500

Published: Sept. 23, 2024

Post COVID-19 condition (PCC) is defined as ongoing symptoms at ≥1 month after acute COVID-19. We investigated the risk of PCC in an international cohort according to viral variants. included 7699 hospitalized patients six centers (January 2020-June 2023); a subset participants with visit over year clinical recovery were analyzed. Variants observed or estimated using Global Data Science Initiative (GISAID) data. Because returning for post may have higher risk, and because variant could be associated probability returning, we used weighted logistic regressions. proportion effect wild-type (WT) virus vs. Omicron on PCC, which was mediated by Intensive Care Unit (ICU) admission, through mediation analysis. In total, 1317 returned COVID median 2.6 (IQR 1.84-3.97) months recovery. WT present 69.6% participants, followed Alpha (14.4%), Delta (8.9%), Gamma (3.9%) strains (3.3%). Among most common manifestations fatigue (51.7%), brain fog (32.7%) respiratory (37.2%). reduced clusters; conversely, variants WT. 42% appeared ICU admission. A infection, suggesting possible reduction burden time. non-negligible seems increased disease severity during disease.

Language: Английский

Citations

1