The Vaginal Microbiome: Key Roles in Reproductive and Systemic Health

Donald School Journal of Ultrasound in Obstetrics & Gynecology, Journal Year: 2025, Volume and Issue: 19(1), P. 10 - 15

Published: March 27, 2025

Language: Английский

A Comparative Longitudinal Study Analyzing Vaginal Microbiota Differences Between Term and Preterm Pregnancies in Korean Women

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 752 - 752

Published: April 18, 2025

Background and Objectives: Preterm birth (PTB), defined as delivery before 37 weeks of gestation, remains a significant public health concern due to its association with neonatal morbidity mortality. Although studies have suggested that microbial factors in vaginal microbiota (VMB) influence PTB, longitudinal research on Korean women is limited. This study aimed analyze VMB differences between term preterm pregnancies their correlation the cervical length (CL). Materials Methods: A cohort 60 pregnant (40 who had (TB) 20 PTB) was recruited. Vaginal samples were collected at five time points (first, second, third trimester; 1–2 postpartum; months postpartum). Microbial DNA extracted analyzed using quantitative PCR targeting 12 bacterial species. The CL measured second trimesters. Results: Lactobacillus crispatus consistently dominant TB group, whereas PTB cases exhibited greater diversity elevated levels Prevotella salivae Ureaplasma significantly shorter cases, correlating shifts composition. Conclusions: stable, Lactobacillus-dominant microbiome protective pregnancy, while increased suggests biomarkers for early risk prediction. Combining profiling measurement may enhance early, non-invasive assessments.

Language: Английский

Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 8, 2025

Periodontitis (PD) is the most common oral infectious disease. The primary etiologic cause of onset and development PD dental plaque, which consists bacterial biofilm domiciled within a complex extracellular mass. In patients, there progressive breakdown periodontal ligament alveolar bone. more advanced stages, tooth loss occurs. progression this chronic inflammatory disease involves interactions among numerous microbial pathogens particularly, bacteria, host's immune factors, various environmental factors. Due to persistent infection by periodonto-pathogenic an impairment both innate acquired immunity, leading tissue destruction. Chronic inflammation in may be associated with several systemic diseases, including cardiovascular conditions, respiratory issues, diabetes, neurological cancer, adverse pregnancy outcomes. Antibiotic treatment one effective strategies for treating cases, although emergence some resistant strains limit effectiveness antibiotics. review study, we discussed main bacteria PD, interaction response, pathogenesis antibiotic treatment. We also outlined resistance antibiotics these pathogens.

Language: Английский