The Vaginal Microbiome: Key Roles in Reproductive and Systemic Health
A Kurjak,
No information about this author
Ulla Marton,
No information about this author
Neda Smiljan Severinski
No information about this author
et al.
Donald School Journal of Ultrasound in Obstetrics & Gynecology,
Journal Year:
2025,
Volume and Issue:
19(1), P. 10 - 15
Published: March 27, 2025
Language: Английский
A Comparative Longitudinal Study Analyzing Vaginal Microbiota Differences Between Term and Preterm Pregnancies in Korean Women
Gina Nam,
No information about this author
Kyung A. Lee,
No information about this author
Soo Jung Kim
No information about this author
et al.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(4), P. 752 - 752
Published: April 18, 2025
Background
and
Objectives:
Preterm
birth
(PTB),
defined
as
delivery
before
37
weeks
of
gestation,
remains
a
significant
public
health
concern
due
to
its
association
with
neonatal
morbidity
mortality.
Although
studies
have
suggested
that
microbial
factors
in
vaginal
microbiota
(VMB)
influence
PTB,
longitudinal
research
on
Korean
women
is
limited.
This
study
aimed
analyze
VMB
differences
between
term
preterm
pregnancies
their
correlation
the
cervical
length
(CL).
Materials
Methods:
A
cohort
60
pregnant
(40
who
had
(TB)
20
PTB)
was
recruited.
Vaginal
samples
were
collected
at
five
time
points
(first,
second,
third
trimester;
1–2
postpartum;
months
postpartum).
Microbial
DNA
extracted
analyzed
using
quantitative
PCR
targeting
12
bacterial
species.
The
CL
measured
second
trimesters.
Results:
Lactobacillus
crispatus
consistently
dominant
TB
group,
whereas
PTB
cases
exhibited
greater
diversity
elevated
levels
Prevotella
salivae
Ureaplasma
significantly
shorter
cases,
correlating
shifts
composition.
Conclusions:
stable,
Lactobacillus-dominant
microbiome
protective
pregnancy,
while
increased
suggests
biomarkers
for
early
risk
prediction.
Combining
profiling
measurement
may
enhance
early,
non-invasive
assessments.
Language: Английский
Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition
Mina Yekani,
No information about this author
Masoumeh Dastgir,
No information about this author
Samaneh Fattahi
No information about this author
et al.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: May 8, 2025
Periodontitis
(PD)
is
the
most
common
oral
infectious
disease.
The
primary
etiologic
cause
of
onset
and
development
PD
dental
plaque,
which
consists
bacterial
biofilm
domiciled
within
a
complex
extracellular
mass.
In
patients,
there
progressive
breakdown
periodontal
ligament
alveolar
bone.
more
advanced
stages,
tooth
loss
occurs.
progression
this
chronic
inflammatory
disease
involves
interactions
among
numerous
microbial
pathogens
particularly,
bacteria,
host's
immune
factors,
various
environmental
factors.
Due
to
persistent
infection
by
periodonto-pathogenic
an
impairment
both
innate
acquired
immunity,
leading
tissue
destruction.
Chronic
inflammation
in
may
be
associated
with
several
systemic
diseases,
including
cardiovascular
conditions,
respiratory
issues,
diabetes,
neurological
cancer,
adverse
pregnancy
outcomes.
Antibiotic
treatment
one
effective
strategies
for
treating
cases,
although
emergence
some
resistant
strains
limit
effectiveness
antibiotics.
review
study,
we
discussed
main
bacteria
PD,
interaction
response,
pathogenesis
antibiotic
treatment.
We
also
outlined
resistance
antibiotics
these
pathogens.
Language: Английский