Mucosal immunity and rheumatoid arthritis: An update on mechanisms and therapeutic potential

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(5), P. 103775 - 103775

Published: Feb. 13, 2025

Rheumatoid Arthritis (RA) is a persistent autoimmune inflammatory disorder that arises from the intricate interaction between genetic predisposition and environmental influences. The progression of RA can be delineated into four distinct phases: initially, influence risk factors; followed by emergence systemic autoimmunity; subsequently, an asymptomatic phase; ultimately, manifestation clinical arthritis. Recently, role mucosal immunity in has gained significant attention research. Evidence published studies suggests not only influences onset but also plays crucial its progression. Scholars have begun to unravel links barriers gastrointestinal tract, respiratory system, oral cavity. Specifically, shifts microbiota, dysfunction barriers, abnormal activation immune tissues are all implicated pathogenesis RA.Despite this growing body knowledge, comprehensive review therapeutic implications yet conducted. This emphasizes driving abnormalities development autoimmunity rheumatoid arthritis (RA). It further explores potential RA, as well issues challenges need addressed current research field, providing new perspective targets for prevention treatment RA.

Language: Английский

Impact of Protein Citrullination by Periodontal Pathobionts on Oral and Systemic Health: A Systematic Review of Preclinical and Clinical Studies

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

This review synthesizes the role of Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (A.a) in modulating immune responses through citrullination assesses its impact on periodontitis systemic conditions. A systematic was conducted preclinical clinical studies focusing Pg- A.a-induced effects responses, particularly inflammatory pathways diseases. The search included PubMed, Scopus, Google Scholar, Web Science, gray literature. Quality risk bias were assessed using OHAT Rob Toll QUIN-Tool. is registered PROSPERO (ID: CRD42024579352). 18 articles published up to August 2024 included. Findings show that Pg A.a modulates leading neutrophil dysfunction chronic inflammation. Key mechanisms include antimicrobial peptides, CXCL10, histone H3, α-enolase, C5a, impairing activation promoting NET formation. suggests may influence conditions like RA. Beyond ACPA production, these pathogens affect key proteins such as well formation, phagocytosis. These interactions lead potentially other cells, subsequently disrupting local responses.

Language: Английский

Impact of Protein Citrullination by Periodontal Pathobionts on Oral and Systemic Health: A Systematic Review of Preclinical and Clinical Studies

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6831 - 6831

Published: Nov. 13, 2024

Background: This review synthesizes the role of Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) in modulating immune responses through citrullination assesses its impact on periodontitis systemic conditions. Methods: A systematic was conducted preclinical clinical studies focusing P. gingivalis- A. actinomycetemcomitans-induced effects responses, particularly inflammatory pathways, diseases. The search included PubMed, Scopus, Google Scholar, Web Science, gray literature. Quality risk bias were assessed using OHAT Rob Toll QUIN-Tool. is registered PROSPERO (ID: CRD42024579352). Results: 18 articles published up to August 2024 included. Findings show that modulates leading neutrophil dysfunction chronic inflammation. Key mechanisms include antimicrobial peptides, CXCL10, histone H3, α-enolase, C5a, impairing activation promoting NET formation. Conclusions: suggests may influence conditions like RA. Beyond ACPA production, these pathogens affect key proteins such as well formation, phagocytosis. These interactions lead potentially other cells, subsequently disrupting local responses.

Language: Английский