Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections During the COVID-19 Era

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11624 - 11624

Published: Oct. 29, 2024

Extensive research has been conducted on the SARS-CoV-2 virus in association with various infectious diseases to understand pathophysiology of infection and potential co-infections. In tropical countries, exposure local viruses may alter course coinfection. Notably, only a portion antibodies produced against proteins demonstrate neutralizing properties, immune response following natural tends be temporary. contrast, long-lasting IgG are common after dengue infections. cases where preexisting from an initial bind different serotype during subsequent infection, there is for antibody-dependent enhancement (ADE) formation complexes associated disease severity. Both infections can result immunodeficiency. Viral both interfere host's IFN-I signaling. Additionally, cytokine storm occur viral impairing proper response, autoantibodies wide array appear convalescence. Most reported typically short-lived. Vaccines affecting enhancing clearance. A comprehensive analysis pathogenicity revisited prevent severity, mortality.

Language: Английский

Epidemiological Study of Respiratory Virus Infections in Pediatric Patients with Systemic Inflammatory Response Syndrome

Jundishapur Journal of Microbiology, Journal Year: 2024, Volume and Issue: 17(9)

Published: Nov. 20, 2024

Background: Respiratory infections are a common cause of systemic inflammatory response syndrome (SIRS) in pediatric patients. However, literature specifically addressing respiratory viruses that lead to SIRS or sepsis children is limited, primarily consisting case reports and lacking data for more comprehensive conclusions. Objectives: This study aims investigate the relationship between viral children, focusing on virus detection rates, patient profiles, incidence septic shock associated with different viruses. Methods: A retrospective analysis was conducted from January 2022 December 2023 hospitalized diagnosed SIRS. were detected through qualitative PCR testing, procalcitonin levels measured using an enzyme-linked fluorescent immunoassay. Results: total 931 patients tested and/or other pathogens. Among these, 298 (32.0%) positive viruses, 263 (28.2%) cases attributed solely Human rhinovirus (HRV) had highest infection rate at 37.3% (98/263), followed by human adenovirus (HAdV) 24.3% (64/263). Seasonal distribution among showed spring (39.5%), summer (25.5%), winter (17.9%), autumn (17.1%). Septic rates influenza A) FluA(, metapneumovirus (hMP), co-infections, incidences 27.8%, 18.2%, 22.7%, respectively. There significant variation across (P < 0.001). Conclusions: Many develop SIRS, subset these can progress shock.

Language: Английский