Morphological and molecular investigation of hydatid cyst isolated from small ruminants in Rasht, Iran DOI

Saeed Farokhpey,

Soheil Sadr,

Saeed Yaghfoori

et al.

Journal of Parasitic Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Development of Phytase Targeted PLGA Nanoparticles Loaded with Albendazole Sulfoxide and Praziquantel and Evaluation of Efficacy on the Hydatid Cysts DOI
Yakup Gültekin, Çağla Korkmaz, Naile Öztürk

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 105, P. 106662 - 106662

Published: Jan. 31, 2025

Language: Английский

Citations

0
Nanotechnology for Effective Bovine Mastitis Treatment: Applications in Biosensors and Vaccines DOI Creative Commons
Soheil Sadr, Babak Khoramian, Zahra Yousefsani

et al.

OpenNano, Journal Year: 2025, Volume and Issue: unknown, P. 100238 - 100238

Published: Feb. 1, 2025

Language: Английский

Citations

0
Investigating the Therapeutic Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules in Hydatid Cyst-Infected Mice DOI Creative Commons

Nooshinmehr Soleymani,

Soheil Sadr, Cinzia Santucciu

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 240 - 240

Published: March 1, 2025

Drug resistance is the main challenge in treating parasitic diseases, including cystic echinococcosis (CE). Hence, current study aims to investigate effect of nanocapsules containing albendazole (ABZ), mebendazole (MBZ), and praziquantel (PZQ) on hydatid cysts mice using these high-potency drugs. A total 78 female white laboratory (BALB/C mice), 8 weeks old weighing 25 g, were intraperitoneally injected with 1500 live protoscoleces Echinococcus granulosus. The first group received ABZ nanocapsules, 2 MBZ 3 PZQ 4 + 5 6 nanocapsules. Each also had a control group, which non-nanocapsulated drugs (group 7–12). Group 13 no treatment served as negative control, just receiving phosphate-buffered saline (PBS). thorough examination cysts’ physical properties, size, quantity, weight, was carried out. According our results, polymeric are sphere-like different sizes. number all nanocapsule groups significantly decreased compared group. In weight cysts, least cyst showing that use medicinal combination better penetration reduction cysts. conclusion, findings showed ABZ, MBZ, reduced mouse model used this study.

Language: Английский

Citations

0
Antiprotozoal Activity and Selectivity Index of Organic Salts of Albendazole and Mebendazole DOI Creative Commons

Miriam Guadalupe Barón-Pichardo,

Janeth Gómez-García,

David Durán-Martínez

et al.

Microbiology Research, Journal Year: 2025, Volume and Issue: 16(4), P. 77 - 77

Published: March 27, 2025

Infections from the protozoa Entamoeba histolytica (E. histolytica), Giardia lamblia (G. lamblia), and Trichomonas vaginalis (T. vaginalis) pose a public health issue, with albendazole mebendazole serving as second-line medications for treating these parasitic infections. However, low aqueous solubility of compounds has led to exploration new strategies enhance their solubility, formation salts being commonly employed strategy. The sulfonates A1, A2, A3 albendazole, along M1, M2, M3 mebendazole, were synthesized. antiparasitic activity in vitro was assessed against trophozoites E. histolytica, G. lamblia, T. vaginalis. A3, demonstrated greater effect (IC50 37.95–125.53 µM) compared positive controls mebendazole. do not exhibit cytotoxic effects at concentrations 500 µM on Vero cell line. Taken together, findings indicate that solid saline phases enhances vitro, which is crucial current search improved, safe, effective agents.

Language: Английский

Citations

0
Morphological and molecular investigation of hydatid cyst isolated from small ruminants in Rasht, Iran DOI

Saeed Farokhpey,

Soheil Sadr,

Saeed Yaghfoori

et al.

Journal of Parasitic Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0