
Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)
Published: May 27, 2025
Abstract Acinetobacter baumannii is notorious for its antimicrobial resistance and potential to cause epidemics in hospital settings, which pose a global health threat. Although this microorganism traditionally considered low-virulence pathogen, extensive research has been conducted on virulence pathogenesis recent years. Advances understanding the mechanisms of A. have prompted shift development anti-infective agents. The outer membrane protein A (AbOmpA) key factor both vitro vivo. AbOmpA exists three forms: membrane-integrated AbOmpA, vesicle (OMV)-associated free proteins. Given that implicated , many studies focused as therapeutic target combating drug-resistant led discovery small molecules, polypeptides, peptides targeting AbOmpA. However, pathophysiological role OMV-associated impact AbOmpA-targeting agents remain unclear. This review summarizes current knowledge critically discusses relation AbOmpA-targeted therapies provide better novel therapeutics against .
Language: Английский