AbOmpA in Acinetobacter baumannii: exploring virulence mechanisms of outer membrane-integrated and outer membrane vesicle-associated AbOmpA and developing anti-infective agents targeting AbOmpA DOI Creative Commons
Man-Hwan Oh, Md Minarul Islam, Nayeong Kim

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: May 27, 2025

Abstract Acinetobacter baumannii is notorious for its antimicrobial resistance and potential to cause epidemics in hospital settings, which pose a global health threat. Although this microorganism traditionally considered low-virulence pathogen, extensive research has been conducted on virulence pathogenesis recent years. Advances understanding the mechanisms of A. have prompted shift development anti-infective agents. The outer membrane protein A (AbOmpA) key factor both vitro vivo. AbOmpA exists three forms: membrane-integrated AbOmpA, vesicle (OMV)-associated free proteins. Given that implicated , many studies focused as therapeutic target combating drug-resistant led discovery small molecules, polypeptides, peptides targeting AbOmpA. However, pathophysiological role OMV-associated impact AbOmpA-targeting agents remain unclear. This review summarizes current knowledge critically discusses relation AbOmpA-targeted therapies provide better novel therapeutics against .

Language: Английский

AbOmpA in Acinetobacter baumannii: exploring virulence mechanisms of outer membrane-integrated and outer membrane vesicle-associated AbOmpA and developing anti-infective agents targeting AbOmpA DOI Creative Commons
Man-Hwan Oh, Md Minarul Islam, Nayeong Kim

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: May 27, 2025

Abstract Acinetobacter baumannii is notorious for its antimicrobial resistance and potential to cause epidemics in hospital settings, which pose a global health threat. Although this microorganism traditionally considered low-virulence pathogen, extensive research has been conducted on virulence pathogenesis recent years. Advances understanding the mechanisms of A. have prompted shift development anti-infective agents. The outer membrane protein A (AbOmpA) key factor both vitro vivo. AbOmpA exists three forms: membrane-integrated AbOmpA, vesicle (OMV)-associated free proteins. Given that implicated , many studies focused as therapeutic target combating drug-resistant led discovery small molecules, polypeptides, peptides targeting AbOmpA. However, pathophysiological role OMV-associated impact AbOmpA-targeting agents remain unclear. This review summarizes current knowledge critically discusses relation AbOmpA-targeted therapies provide better novel therapeutics against .

Language: Английский

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