Experimental PTSD Models in Zebrafish: A Systematic Review of Behavioral, Neurochemical, and Molecular Outcomes DOI Creative Commons
Alexey Sarapultsev, Evgeni Gusev, Desheng Hu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 456 - 456

Published: April 23, 2025

Post-traumatic stress disorder (PTSD) is a complex psychiatric condition characterized by persistent behavioral and neurobiological alterations following trauma. Although rodent models are commonly used to study PTSD, zebrafish (Danio rerio) have emerged as promising alternative due their genetic similarity humans, conserved response systems, high-throughput capabilities. This systematic review evaluates 33 experimental studies on PTSD models, focusing behavioral, neurochemical, molecular outcomes. Chronic unpredictable (CUS/UCS) paradigms of 14–15 days were identified the most reliable for inducing PTSD-like phenotypes, consistently resulting in anxiety-like behaviors, cortisol dysregulation, gene expression changes. In contrast, acute produced transient effects, social defeat showed methodological variability. frequently demonstrated neurotransmitter imbalances, oxidative stress, upregulation inflammatory neuroplasticity-related genes. However, literature revealed challenges, including protocol heterogeneity, limited sex-specific analyses, constraints longitudinal biomarker tracking. Future directions include epigenetic profiling, environmental standardization, cross-species validation. When with rigor, offer powerful translationally relevant platform mechanisms screen novel interventions.

Language: Английский

Experimental PTSD Models in Zebrafish: A Systematic Review of Behavioral, Neurochemical, and Molecular Outcomes DOI Creative Commons
Alexey Sarapultsev, Evgeni Gusev, Desheng Hu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 456 - 456

Published: April 23, 2025

Post-traumatic stress disorder (PTSD) is a complex psychiatric condition characterized by persistent behavioral and neurobiological alterations following trauma. Although rodent models are commonly used to study PTSD, zebrafish (Danio rerio) have emerged as promising alternative due their genetic similarity humans, conserved response systems, high-throughput capabilities. This systematic review evaluates 33 experimental studies on PTSD models, focusing behavioral, neurochemical, molecular outcomes. Chronic unpredictable (CUS/UCS) paradigms of 14–15 days were identified the most reliable for inducing PTSD-like phenotypes, consistently resulting in anxiety-like behaviors, cortisol dysregulation, gene expression changes. In contrast, acute produced transient effects, social defeat showed methodological variability. frequently demonstrated neurotransmitter imbalances, oxidative stress, upregulation inflammatory neuroplasticity-related genes. However, literature revealed challenges, including protocol heterogeneity, limited sex-specific analyses, constraints longitudinal biomarker tracking. Future directions include epigenetic profiling, environmental standardization, cross-species validation. When with rigor, offer powerful translationally relevant platform mechanisms screen novel interventions.

Language: Английский

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