Electroresponsive and pH-Sensitive Hydrogel as Carrier for Controlled Chloramphenicol Release

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(3), P. 1432 - 1444

Published: Feb. 23, 2023

Multiresponsive hydrogels, which are smart soft materials that respond to more than one external stimulus, have emerged as powerful tools for biomedical applications, such drug delivery. Within this context and with the aim of eliminating systematic administration antibiotics, special attention is being paid development systems controlled delivery antibiotic topical treatment bacterial infections. In work, an electro-chemo responsive hydrogel able release chloramphenicol (CAM), a broad spectrum also used anticancer therapy, proposed. This has been prepared by grafting poly(acrylic acid) (PAA) sodium alginate (Alg) in situ encapsulation poly(3,4-ethylenedioxythiophene) nanoparticles loaded CAM (PEDOT/CAM NPs), were obtained emulsion polymerization. Although response electrical stimuli PEDOT was main control from PEDOT/CAM NPs, passive diffusion had relatively important contribution. Conversely, whole engineered system, Alg-

Language: Английский

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Indicative bacterial cellulose films incorporated with curcumin-embedded Pickering emulsions: Preparation, antibacterial performance, and mechanism

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153284 - 153284

Published: June 18, 2024

Language: Английский

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Curcumin Encapsulation in Geranium Oil Microemulsion Elevates Its Antibacterial, Antioxidant, Anti-Inflammatory, and Anticancer Activities

ACS Omega, Journal Year: 2024, Volume and Issue: 9(5), P. 5624 - 5636

Published: Jan. 23, 2024

One of the major challenges with curcumin is its poor solubility in water, which limits absorption and bioavailability body. This study aimed to develop characterize stable microemulsions (MEs) as MEs increase dispersibility water aid Curcumin-loaded were developed goal enhancing topical delivery pharmacological activity (antioxidant, antibacterial, anticancer activity, anti-inflammatory). The pseudoternary phase diagram was constructed find out desired microemulsion region. prepared (ME1–ME5) evaluated for pH, viscosity, size particle, electrical conductivity, zeta potential, ex vivo permeation drug. optimized ME formulation selected based on particle further biological (in vitro/vivo). In vitro cytotoxic effects formulations checked human liver cancer cell line, HEPG2 (a line exhibiting epithelial-like morphology that isolated from a hepatocellular carcinoma). Geranium oil, Tween 80 (as surfactant), propylene glycol cosurfactant) screened formulate MEs. (ME5), composition 20:50:30 (geranium oil:Tween 80:propylene glycol), exhibited pH 4.36 ± 0.057, conductivity 40.06 0.05 μS/cm, viscosity 165 0.37 mPa·s, droplet diameter 199.39 0.017 nm. demonstrated significant cumulative amount permeated 24 h had flux 130.91 0.02 μg/cm2/h. Antioxidant curcumin-loaded (ME5) higher scavenging (99.27 0.021%) than blank (94.67 0.001%). Optimized zones inhibition 25.18 28.37 mm against Escherichia coli Staphylococcus aureus, respectively. Among lines tested, concentration ME5 showed greatest cytotoxicity % viability 8.22 1.09%. Evidently, it also revealed anti-inflammatory 93.29 0.030% by carrageenan-induced paw edema model (6 study) 88.39 0.002% formalin-induced (14 day study). conclusion, safe effective potential antioxidant, cytotoxic, activities.

Language: Английский

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Hydrocolloid-based nutraceutical delivery systems: Potential of κ-carrageenan hydrogel beads for sustained release of curcumin

Food Research International, Journal Year: 2024, Volume and Issue: 183, P. 114223 - 114223

Published: March 13, 2024

Language: Английский

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Smart chitosan films as intelligent food packaging: An approach to monitoring food freshness and biomarkers

Food Packaging and Shelf Life, Journal Year: 2024, Volume and Issue: 46, P. 101370 - 101370

Published: Oct. 17, 2024

Language: Английский

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