Exploring the therapeutic potential of chlorogenic acid in alleviating olanzapine-induced metabolic syndrome in rats: a key role of hypothalamic satiety proteins DOI

Zeinab Ebrahimian,

Bibi Marjan Razavi, Seyed Ali Mousavi Shaegh

et al.

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 9, 2025

Objectives: Olanzapine (Olz) is an effective antipsychotic medication for schizophrenia; however, its use associated with weight gain and metabolic disorders. Chlorogenic acid (CGA), a dietary polyphenol, has promising potential the treatment of obesity, diabetes, hypertension. This study aimed to determine whether CGA could effectively manage Olz-induced syndrome (MetS) in rat model, metformin (Met) as positive control.Methods: Female Wistar rats were divided into seven groups: control; Olz (5 mg/kg/day, IP); (20, 40, 80 gavage) plus Olz; Met (100 (80 30 days. Metabolic parameters including body weight, fasting blood glucose, triglycerides, pressure assessed. focused on evaluating serum levels leptin adiponectin, well hypothalamic protein expression pro-opiomelanocortin (POMC), neuropeptide Y (NPY), AMP-activated kinase (AMPK), 5-HT2C receptors (5-HT2CR), which are known influence energy balance potentially play role abnormalities.Results: caused substantial hyperphagia, gain, hypertension, liver damage, along elevated levels. mitigated these effects, although elevation adiponectin remained unaffected by either treatment. Mechanistically, reduced 5-HT2CR levels, trend that was observed therapy groups. also enhanced NPY pAMPK/AMPK ratio while lowering POMC These alterations reversed administered or Met.Discussion: findings suggest attenuated adverse consequences modulating leptin, NPY, POMC, AMPK CGA's therapeutic highlights intervention managing antipsychotic-induced disturbances.

Language: Английский

Bibliometric Analysis of Antipsychotic-induced Metabolic Disorder from 2006 to 2021 Based on WoSCC Database DOI

Zhihao Guo,

Zi Zhang,

Lu Li

et al.

Current Neuropharmacology, Journal Year: 2025, Volume and Issue: 23(4), P. 439 - 457

Published: Jan. 7, 2025

Background: With the frequent use of antipsychotics, metabolic disorder (MetD) caused by drugs has received increasing attention. However, mechanism drug-induced MetD is still unclear and being explored. Keeping abreast progress trending knowledge in this area conducive to further work. Objective: The aim study analyze latest status trends research on antipsychoticinduced (AIMetD) bibliometric visual analysis. Methods: 3478 publications AIMetD from 2006 2021 were retrieved Web Science Core Collection database. R-biblioshiny was used for descriptive analysis, CiteSpace cooperative network, co-citation analysis burst detection, VOSviewer co-occurrence keywords used. Results: Since 2006, have been growing fluctuantly. These studies extensive cooperation among countries/regions. most influential country/region, institution author are USA, King's College London Christoph U Correll. Analysis references shows largest cluster "antipsychotic-induced dysfunction", which an important basis MetD. recent contents citation related "glucose homeostasis" "cardiovascular metabolism". Several bursting discerned at forefront, including "LC-MS/MS", "major depressive disorder", "expression", "homeostasis". Conclusion: a state sustained development. Close between countries/ regions promoted progress. For grasping foundation, development, AIMetD, it recommended focus active institutions authors. Based subdivision areas such as "homeostasis" forefronts that deserve constant

Language: Английский

Citations

0
A systematic review and meta-analysis of the effects of combined aripiprazole on glycolipid metabolism in schizophrenia DOI Creative Commons
Timothy Wei, Limei Jiang, Ruilin Zhang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Current research on aripiprazole adjunct therapy suggests potential benefits in improving psychiatric symptoms and metabolic disorders patients with schizophrenia. However, the evidence remains limited due to scarcity of a lack detailed analysis glucose lipid metabolism indicators. This study aims systematically review analyze randomized controlled trials (RCTs) evaluate effects combination both glycolipid metabolism. A systematic search PubMed, EMBASE, Web Science databases was conducted identify investigating impact clinical symptoms. Adjuvant treatment reduced blood glucose, triglycerides, total cholesterol, LDL levels schizophrenia, but had no significant effect HDL levels. In addition, results showed improvement parameters at short-term (≤ 8 weeks) dosing doses >15 mg. adjuvant may lead worsening symptoms, so caution is required when using it clinically. Aripiprazole shows parameters, more comprehensive needed solidify these findings, particularly regarding

Language: Английский

Citations

0
Inside the impulsive brain: a narrative review on the role of neurobiological, hormonal and genetic factors influencing impulsivity in psychiatric disorders DOI Creative Commons
Hannah Raji,

Susha Dinesh,

Sameer Sharma

et al.

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Journal Year: 2025, Volume and Issue: 61(1)

Published: Jan. 20, 2025

Abstract This abstract delves into the intricate nature of impulsivity and its ramifications across psychiatric disorders, leveraging advancements in neuroimaging psychological studies. It elucidates diverse facets impulsivity, encompassing response, choice, tendencies, emphasizing pivotal role executive functioning social development. The interplay hormonal influences, specifically cortisol, adrenaline, testosterone, is meticulously examined, unveiling associations between elevated cortisol levels, excessive adrenaline release, heightened impulsivity. ventromedial prefrontal cortex (VMPFC) assumes a central decision-making emotional regulation, demonstrating correlations with conditions, such as antisocial behavior mood disorders. Substantial contributions from neurotransmitters like dopamine serotonin to impulsive underscore imperative need for genetic neurochemical investigations identify factors crucial effective management. Interconnections stress, are accentuated, particularly Hormones, leptin ghrelin, conjunction hypothalamic–pituitary–adrenal axis, play roles conditions major depressive disorder. Concurrently, resistance exerts influence over appetite regulation. nexus substance use disorders emphasizes involvement neurobiological, neurotransmitter, components, guiding targeted interventions. Recognition gender-specific behaviors influences tailoring treatment plans. Advocating comprehensive approach that integrates assessments clinical evaluations, taking account neurobiological context, essential. While systems show promise treating aggressiveness, challenges encompass interactions, ethical considerations, limited options, necessity individualized approaches. Addressing these intricacies advancing knowledge formulating interventions Impulsive Control Disorders.

Language: Английский

Citations

0
Association between the COX-2 rs689466 polymorphism and antipsychotic treatment: Impact on HDL cholesterol changes in clozapine-treated psychosis patients DOI
Sergej Nadalin,

Ivan Ljoka,

Aleksandar Savić

et al.

Prostaglandins Leukotrienes and Essential Fatty Acids, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the therapeutic potential of chlorogenic acid in alleviating olanzapine-induced metabolic syndrome in rats: a key role of hypothalamic satiety proteins DOI

Zeinab Ebrahimian,

Bibi Marjan Razavi, Seyed Ali Mousavi Shaegh

et al.

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 9, 2025

Objectives: Olanzapine (Olz) is an effective antipsychotic medication for schizophrenia; however, its use associated with weight gain and metabolic disorders. Chlorogenic acid (CGA), a dietary polyphenol, has promising potential the treatment of obesity, diabetes, hypertension. This study aimed to determine whether CGA could effectively manage Olz-induced syndrome (MetS) in rat model, metformin (Met) as positive control.Methods: Female Wistar rats were divided into seven groups: control; Olz (5 mg/kg/day, IP); (20, 40, 80 gavage) plus Olz; Met (100 (80 30 days. Metabolic parameters including body weight, fasting blood glucose, triglycerides, pressure assessed. focused on evaluating serum levels leptin adiponectin, well hypothalamic protein expression pro-opiomelanocortin (POMC), neuropeptide Y (NPY), AMP-activated kinase (AMPK), 5-HT2C receptors (5-HT2CR), which are known influence energy balance potentially play role abnormalities.Results: caused substantial hyperphagia, gain, hypertension, liver damage, along elevated levels. mitigated these effects, although elevation adiponectin remained unaffected by either treatment. Mechanistically, reduced 5-HT2CR levels, trend that was observed therapy groups. also enhanced NPY pAMPK/AMPK ratio while lowering POMC These alterations reversed administered or Met.Discussion: findings suggest attenuated adverse consequences modulating leptin, NPY, POMC, AMPK CGA's therapeutic highlights intervention managing antipsychotic-induced disturbances.

Language: Английский

Citations

0