Exploring the Roles and Clinical Potential of Exosome-Derived Non-Coding RNAs in Glioma DOI Creative Commons
Peng Jin, Xue Bai

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 323 - 337

Published: Feb. 6, 2025

Non-coding accounts for 98 %-99 % of the human genome and performs many essential regulatory functions in eukaryotes, involved cancer development development. RNAs are abundantly enriched exosomes, which play a biological role as vectors. Some biofunctional non-coding specifically designed exosomes treatment cancers such glioma. Glioma is one most common primary tumors within skull has varying degrees malignancy histologic subtypes grades I-IV. Gliomas characterized by high an abundant blood supply due to rapid cell proliferation vascularization, often with poor prognosis. Exosomal can be tumorigenesis process glioma from multiple directions, angiogenesis, tumor proliferation, metastatic invasion, immune evasion, apoptosis, autophagy. Therefore, suitable markers or therapeutic targets early diagnosis diseases predicting prognosis variety diseases. Regulating exosome production level exosomal RNA expression may new approach prevent eliminate In this review, we review origin characteristics RNAs, introduce functional studies their potential clinical applications, order broaden ideas

Language: Английский

The emerging roles of circRNAs in cancer and oncology DOI
Lasse S. Kristensen, Theresa Jakobsen, Henrik Hager

et al.

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 19(3), P. 188 - 206

Published: Dec. 15, 2021

Language: Английский

Citations

818
Exosomes as a new frontier of cancer liquid biopsy DOI Creative Commons
Dan Yu,

Yixin Li,

Maoye Wang

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Feb. 18, 2022

Abstract Liquid biopsy, characterized by minimally invasive detection through biofluids such as blood, saliva, and urine, has emerged a revolutionary strategy for cancer diagnosis prognosis prediction. Exosomes are subset of extracellular vesicles (EVs) that shuttle molecular cargoes from donor cells to recipient play crucial role in mediating intercellular communication. Increasing studies suggest exosomes have great promise serve novel biomarkers liquid since large quantities enriched body fluids involved numerous physiological pathological processes. However, the further clinical application been greatly restrained lack high-quality separation component analysis methods. This review aims provide comprehensive overview on conventional technologies exosome isolation, characterization content detection. Additionally, roles serving potential biopsy diagnosis, treatment monitoring, prediction summarized. Finally, prospects challenges applying exosome-based precision medicine evaluated.

Language: Английский

Citations

565
Going circular: history, present, and future of circRNAs in cancer DOI Creative Commons
Giuseppina Pisignano, David C. Michael, Tanvi H. Visal

et al.

Oncogene, Journal Year: 2023, Volume and Issue: 42(38), P. 2783 - 2800

Published: Aug. 16, 2023

Abstract To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional that shown to regulate gene expression transcriptionally post-transcriptionally exhibit distinct tissue- development-specific patterns associated with a variety normal disease conditions, including cancer pathogenesis. Over the past years, due their intrinsic stability resistance ribonucleases, particular attention has drawn use as reliable diagnostic prognostic biomarkers in diagnosis, treatment, prevention. However, there some critical caveats utility clinic. Their circular shape limits annotation complete functional elucidation is lacking. This makes detection biomedical application still challenging. Herein, we review current knowledge circRNA biogenesis function, involvement tumorigenesis potential cancer-targeted therapy.

Language: Английский

Citations

112
Genetic and Epigenetic Alterations Induced by Pesticide Exposure: Integrated Analysis of Gene Expression, microRNA Expression, and DNA Methylation Datasets DOI Open Access

Federica Giambò,

Gian Marco Leone, Giuseppe Gattuso

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(16), P. 8697 - 8697

Published: Aug. 17, 2021

Environmental or occupational exposure to pesticides is considered one of the main risk factors for development various diseases. Behind pesticide-associated pathologies, there are both genetic and epigenetic alterations, where these latter mainly represented by alteration in expression levels microRNAs change methylation status DNA. At present, no studies have comprehensively evaluated alterations induced pesticides; therefore, aim present study was identify modifications gene miRNA DNA useful prediction pesticide exposure. For this purpose, an integrated analysis expression, microRNA datasets obtained from GEO DataSets database performed putative genes, microRNAs, hotspots associated with responsible different In addition, DIANA-miRPath, STRING, GO Panther tools were used establish functional role biomarkers identified. The results demonstrated that can modulate genes induce miRNAs modulation status.

Language: Английский

Citations

57
Extracellular vesicles in glioblastoma: a challenge and an opportunity DOI Creative Commons
Vineesh Indira Chandran, Srinivas Gopala,

Easwer Hariharan Venkat

et al.

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: May 17, 2024

Abstract Glioblastoma is a highly heterogeneous tumor whose pathophysiological complexities dictate both the diagnosis of disease severity as well response to therapy. Conventional diagnostic tools and standard treatment regimens have only managed achieve limited success in management patients suspected glioblastoma. Extracellular vesicles are an emerging liquid biopsy tool that has shown great promise resolving limitations presented by nature Here we discuss contrasting yet interdependent dual role extracellular communication agents contribute progression glioblastoma creating microenvironment providing opportunity accurately identify progression.

Language: Английский

Citations

10
Empowering rapid diagnosis and treatment of glioblastoma with biofunctionalized carbon quantum dots: a review DOI Creative Commons
Kimia Kazemi, Abbas Amini, Navid Omidifar

et al.

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 14, 2025

Language: Английский

Citations

1
Advanced technologies for molecular diagnosis of cancer: State of pre-clinical tumor-derived exosome liquid biopsies DOI Creative Commons
Lin Li, Lili Zhang, Katelynn C. Montgomery

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100538 - 100538

Published: Dec. 29, 2022

Exosomes are membrane-defined extracellular vesicles (EVs) approximately 40–160 ​nm in diameter that found all body fluids including blood, urine, and saliva. They act as important vehicles for intercellular communication between both local distant cells can serve circulating biomarkers disease diagnosis prognosis. play a key role tumor metastasis, abundant biofluids, stabilize they carry, thus improve cancer detection, treatment monitoring, staging/prognosis. Despite their clinical potential, lack of sensitive/specific sensitive isolation/enrichment analytical technologies has posed barrier to translation exosomes. This review presents critical overview now being used detect tumor-derived exosome (TDE) specimens have potential translation.

Language: Английский

Citations

36
Liquid Biopsy and Circulating Biomarkers for the Diagnosis of Precancerous and Cancerous Oral Lesions DOI Creative Commons
Giuseppe Gattuso, Salvatore Crimi, Alessandro Lavoro

et al.

Non-Coding RNA, Journal Year: 2022, Volume and Issue: 8(4), P. 60 - 60

Published: Aug. 10, 2022

Oral cancer is one of the most common malignancies worldwide, accounting for 2% all cases annually and 1.8% deaths. To date, tissue biopsy histopathological analyses are gold standard methods diagnosis oral cancers. However, generally diagnosed at advanced stages with a consequent poor 5-year survival (~50%) due to limited screening programs inefficient physical examination strategies. address these limitations, liquid recently emerging as novel minimally invasive tool early identification tumors well evaluation tumor heterogeneity prognosis patients. Several studies have demonstrated that in could be useful detection circulating biomarkers including DNA (ctDNA), microRNAs (miRNAs), proteins, exosomes, thus improving diagnostic strategies paving way personalized medicine. application still further needed better clarify its clinical impact. The present manuscript aims provide an updated overview potential use additional management lesions by describing available methodologies promising biomarkers.

Language: Английский

Citations

32
Exosomal circRNAs as promising liquid biopsy biomarkers for glioma DOI Creative Commons

Xiaoke Wu,

Mengmeng Shi, Yajun Lian

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 14, 2023

Liquid biopsy strategies enable the noninvasive detection of changes in levels circulating biomarkers body fluid samples, providing an opportunity to diagnose, dynamically monitor, and treat a range diseases, including cancers. Glioma is among most common forms intracranial malignancy, affected patients exhibit poor prognostic outcomes. As such, diagnosing treating this disease its early stages critical for optimal patient Exosomal circular RNAs (circRNAs) are involved both onset progression glioma. Both roles exosomes methods their have received much attention recent years exosomal circRNAs by liquid has significant potential monitoring dynamic The present review provides overview associated with cancer type application as tools guide diagnosis, treatment, evaluation glioma during progression.

Language: Английский

Citations

17
Extracellular vesicles in glioblastoma: Biomarkers and therapeutic tools DOI Creative Commons
Ilaria Cela, Emily Capone, Gianluca Trevisi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 101, P. 25 - 43

Published: May 14, 2024

Glioblastoma (GBM) is the most aggressive tumor among gliomas and intracranial tumors to date prognosis for GBM patients remains poor, with a median survival typically measured in months few years depending on various factors. Although standardized therapies are routinely employed, it clear that these strategies unable cope heterogeneity invasiveness of GBM. Furthermore, diagnosis monitoring responses directly dependent tissue biopsies or magnetic resonance imaging (MRI) techniques. From this point view, liquid arising as key sources variety biomarkers advantage being easily accessible monitorable. In context, extracellular vesicles (EVs), physiologically shed into body fluids by virtually all cells, gaining increasing interest both natural carriers specific signatures even What makes particularly attractive they also emerging therapeutical vehicles treat given their native ability cross blood-brain barrier (BBB). Here, we reviewed recent advances use EVs biomarker biopsy nanocarriers targeted delivery anticancer drugs glioblastoma.

Language: Английский

Citations

8