Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7165 - 7165

Published: Oct. 19, 2023

Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety natural modified peptides have been obtained studied, many others advancing in clinical trials, covering multiple therapeutic areas. As demand peptide-based therapies grows, so does need sustainable environmentally friendly synthesis methods. Traditional peptide synthesis, while effective, involves draining processes, generating significant waste consuming vast resources. The integration green chemistry offers alternatives, prioritizing eco-friendly reduction, energy conservation. This review delves into transformative potential applying principles by discussing relevant examples application such approaches production active ingredients (APIs) with a structure how these efforts critical an effective transition era field.

Language: Английский

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Strategies of plants to overcome abiotic and biotic stresses

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2024, Volume and Issue: 99(4), P. 1524 - 1536

Published: April 1, 2024

ABSTRACT In their environment, plants are exposed to a multitude of abiotic and biotic stresses that differ in intensity, duration severity. As sessile organisms, they cannot escape these stresses, but instead have developed strategies overcome them or compensate for the consequences stress exposure. Defence can take place at different levels mechanisms involved thought efficiency across levels. To minimise metabolic constraints reduce costs defence, prioritise first‐line defence apoplastic space, involving ascorbate, defensins small peptides, as well secondary metabolites, before cellular processes affected. addition, large number symplastic also provide efficient including chemical antioxidants, antioxidative enzymes, other peptides proteins. At both level compensation, specialised transporters be exchange membranes still not been identified, information on regeneration compounds remains ambiguous. exposure operate only cellular, organ whole‐plant levels, stomatal regulation, hypersensitive systemic responses prevent spread impacts within plant. ecosystem by root exudation signalling molecules emission volatile organic compounds, either directly indirectly into rhizosphere and/or aboveground atmosphere. The which control production mediate perception stressful conditions fully understood. Here we summarise plant from level, discuss advantages disadvantages growth development, elucidate current state research transport capacity outline insufficiently explored questions further investigation.

Language: Английский

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Antimicrobial peptides with antiviral and anticancer properties and their modification and nanodelivery systems

Current Research in Biotechnology, Journal Year: 2023, Volume and Issue: 5, P. 100121 - 100121

Published: Jan. 1, 2023

Antimicrobial peptides (AMPs) are natural biopolymers in the host defense system. AMPs display multiple functions against bacterial, fungal, and viral infection, as well anticancer properties. promising antiviral agents. The average size, net charge, hydrophobicity residue percentage of these Peptide Database (APD) 26 amino acids, 3.5 (+), 48 %, respectively. However, pharmacokinetic disadvantages such low proteolytic chemical stability, high cytotoxicity hemolytic activity, salt sensitivity inhibit their clinical application. Given effects on features, circumventing drawbacks improving efficacy critically important for structure acid components can be modified by several methods, including stabilization, hybridization, cyclization, fragmentation, multimerization, alteration conjugation or ligation. Furthermore, nanotechnologies effective tools strategies to improve reduce side effects. For example, melittin-nano its therapeutic minimize nonspecific cytotoxicity. Clinical trials waiting evaluate delivery system novel treatments.

Language: Английский

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Plant protein-derived peptides: frontiers in sustainable food system and applications

Frontiers in Sustainable Food Systems, Journal Year: 2024, Volume and Issue: 8

Published: April 10, 2024

Plant proteins have been considered a potential source of bio-functional peptides, which can be beneficial for human health. The potent antioxidant properties plant-based peptides protect against oxidative damage and associated diseases. Despite significant number studies on the preparation biological functions only limited are commercially utilized. systematic extraction, optimization, isolation, pharmacokinetics, stability, safety aspects plant protein-derived (PPDP) in progress. Also, molecular mechanism action health benefits bioactive PPDP is still lacking. Hence, this review provides comprehensive discussion various protein sources to end-product applications PPDP. In context, different explored functional presented. green biotechnological techniques such as fermentation enzymatic hydrolysis extraction described. revisited. most important part application includes stability bioavailability has discussed. Additionally, impact administration summarized. Lastly, future perspectives concluding remarks documented.

Language: Английский

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A review on current status of antiviral peptides

Discover Viruses., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 28, 2025

Language: Английский

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A critical review of novel antibiotic resistance prevention approaches with a focus on postbiotics

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 19

Published: May 19, 2023

Antibiotic resistance is a significant public health issue, causing illnesses that were once easily treatable with antibiotics to develop into dangerous infections, leading substantial disability and even death. To help fight this growing threat, scientists are developing new methods techniques play crucial role in treating infections preventing the inappropriate use of antibiotics. These effective therapeutic include phage therapies, quorum-sensing inhibitors, immunotherapeutics, predatory bacteria, antimicrobial adjuvants, haemofiltration, nanoantibiotics, microbiota transplantation, plant-derived antimicrobials, RNA therapy, vaccine development, probiotics. As result activity probiotics intestine, compounds derived from structure metabolism these bacteria obtained, called postbiotics, which multiple agents various applications, especially effects, by using different mechanisms. have been chosen particular because they don't promote spread antibiotic substances can increase resistance. This manuscript provides an overview novel approaches emphasis on postbiotic metabolites gut beneficial microbes, their activities, recent related progressions food medical fields, as well concisely giving insight concept postbiotics "hyperpostbiotic"

Language: Английский

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The Influence of Cholesterol on Membrane Targeted Bioactive Peptides: Modulating Peptide Activity Through Changes in Bilayer Biophysical Properties

Membranes, Journal Year: 2024, Volume and Issue: 14(10), P. 220 - 220

Published: Oct. 17, 2024

Cholesterol is a biological molecule that essential for cellular life. It has unique features in terms of molecular structure and function, plays an important role determining the properties cell membranes. One most recognized functions cholesterol its ability to increase level lipid packing rigidity membranes while maintaining high levels lateral mobility bulk lipids, which necessary sustain biochemical signaling events. There increased interest designing bioactive peptides can act as effective antimicrobial agents without causing harm human cells. For this reason, it becomes relevant understand how affect interaction between membranes, particular by modulating peptides’ penetrate disrupt through these changes membrane rigidity. Here we discuss bilayer recent evidence showing modulates different degrees.

Language: Английский

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A comprehensive characterization and expression profiling of defensin family peptides in Arabidopsis thaliana with a focus on their abiotic stress-specific transcriptional modulation

Current Plant Biology, Journal Year: 2024, Volume and Issue: 39, P. 100376 - 100376

Published: July 31, 2024

In addition to defensins, plants possess an array of defensin-like peptides that share many their characteristics, as well a role in plant's innate immunity. Their involvement the response pathogens is well-known but contribution plant abiotic stimuli not fully understood. We have undertaken silico analysis characterize all defensin family genes hitherto found Arabidopsis, including encoding for peptides, by detecting several candidates further studies aiming decipher specific responses biotic and stresses, crosstalk. performed analyses, co-expression cis-regulatory elements using transcriptomic data obtained from ARS database, which integrates more than 20,000 Arabidopsis RNA-seq libraries. showed jasmonates ABA, together with transcription factors belonging WRKY AP2/EREBP families, modulate gene expression. Indeed, this study allowed extract organize omics data, finally supported inducible nature defensins under both stresses. Moreover, vivo expression analyses confirmed heat drought responsiveness PDF1.4, ATTI1, PDF1.1, DEFL 206, selected being upregulated conditions, at transcriptional level. Finally, provided information on other biological processes may be correlated induction, such maintaining ROS homeostasis. Combining comprehensive different datasets integration emerged robust methodological approach assess proposed multi-stress responsive genes.

Language: Английский

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The Updated Review on Plant Peptides and Their Applications in Human Health

International Journal of Peptide Research and Therapeutics, Journal Year: 2022, Volume and Issue: 28(5)

Published: July 27, 2022

Language: Английский

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Antimicrobial Peptides Against Arboviruses: Mechanisms, Challenges, and Future Directions

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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