Heat-killed Lactiplantibacillus plantarum WB3813 and Lactiplantibacillus plantarum WB3814 Alleviate LPS-Induced Inflammatory Damage and Apoptosis in A549 Cells

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

---

The synergistic link between sonic hedgehog signaling pathway and gut–lung axis: Its influential role toward chronic obstructive pulmonary disease progression

Developmental Dynamics, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Sonic Hedgehog (SHH) is an evolutionarily conserved signaling pathway essential for embryonic development, tissue homeostasis, and tumorigenesis. Aberrant activation of the SHH induces various types cancer different immune dysregulation. extremely important morphogen during lung as it regulates interaction between epithelial mesenchymal transitions (EMT) in airways. Cigarette smoking triggers EMT activates pathway, which leads to damage development diseases, such COPD, a smoker's disease. also directs gut–lung axis (GLA) formation via epithelial–mesenchymal signaling. The abruption or alteration GLA responsible COPD pathogenesis. In this review, we elucidate overview its inhibitor HHIP, SHH's prominence dysregulation pathogenesis link with clinical features. We provide insights into linked nicotine their influence on

Language: Английский

---

Targeting CXCR2 signaling in inflammatory lung diseases: neutrophil-driven inflammation and emerging therapies

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

---

Fibroblast-derived osteoglycin promotes epithelial cell repair

npj Regenerative Medicine, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 25, 2025

There is an urgent need for innovative therapies targeting defective epithelial repair in chronic diseases like COPD. The mesenchymal niche a critical regulator stem cell activation, suggesting that their secreted factors are possible potent drug targets. Utilizing proteomics-guided discovery strategy, we explored the lung fibroblast secretome to uncover impactful Our organoid assays identified several regenerative ligands, with osteoglycin (OGN) showing most profound effects. Transcriptomic analyses revealed OGN enhances alveolar progenitor differentiation, detoxifies reactive oxygen species, and strengthens fibroblast-epithelial crosstalk. expression was diminished COPD patients smoke-exposed mice. An active fragment of (leucine-rich repeat regions 4-7) replicated full-length OGN's effects, significantly ameliorating elastase-induced injury slices improving function vivo. These findings highlight as pivotal protein repair, positioning its promising therapeutic

Language: Английский

---

Emerging trends and hotspots in chronic obstructive pulmonary disease and oxidative stress: a bibliometric and visualized analysis from 2010 to 2024

Journal of Thoracic Disease, Journal Year: 2025, Volume and Issue: 17(3), P. 1228 - 1248

Published: March 1, 2025

Chronic obstructive pulmonary disease (COPD) is a long-term respiratory condition defined by ongoing symptoms and restricted airflow, resulting in high rates of morbidity, mortality, disability for this condition. Due to the incomplete understanding its pathogenesis, no permanent curative measures or specific drugs are available. In recent years, multitude research has highlighted substantial influence oxidative stress on development COPD; however, there been deficiency bibliometric analyses focusing trends hotspots field. Therefore, our study aimed at presenting emerging related COPD stress. Publications concerning were obtained from Web Science Core Collection database, covering period 2010 2024. On July 25, 2024, all relevant data downloaded, followed process screening analysis. The analysis incorporated 1,308 articles 440 reviews, involving contributions 1,034 researchers affiliated with 512 institutions across 64 countries published total 548 journals. Through series using five visualization tools, we identified top 5 most productive countries, institutions, journals, highly co-cited journals field We also 12 citation clusters, 10 influential authors, authors articles, 11 keyword established 20 keywords, observed evolution reference bursts. This first quantitatively capture progress research, results show marked upward trend years terms Developing novel effective antioxidants becoming future direction treatment. Besides antioxidant therapy, exposure (to air pollution), cigarette smoke, mitochondrial dysfunction emerged as prominent hotspots. extensive offers significant insights into exploration publications purpose support enhance scientific investigators

Language: Английский

---

Association of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with COPD prevalence and all-cause mortality: a population-based study based on NHANES 2007–2016

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 3, 2025

The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) plays a potential role in metabolic and cardiovascular diseases. However, its association with chronic obstructive pulmonary disease (COPD) is not well-defined. Here, we aim investigate the of NHHR both prevalence COPD all-cause mortality among individuals COPD. This population-based NHANES (2007-2016) study utilized weighted statistical analyses. Multivariable logistic regression assessed NHHR-COPD association, restricted cubic spline (RCS) testing for non-linearity. between was evaluated using Cox proportional hazards models Kaplan-Meier, RCS Subgroup sensitivity analyses confirmed findings' reliability. included 6349 participants, whom 1271 were diagnosed Participants highest tertile demonstrated 62% higher odds compared those lowest (OR = 1.62, 95% CI:1.11-2.39, P 0.017). Results from analysis indicated nonlinear relationship (P 0.007), curve demonstrating an inverted L-shape. Over average follow-up period 93 months, 320 participants died. In Kaplan-Meier survival analysis, lower greater cumulative probability tertiles < 0.001). Weighted multivariable revealed inverse levels mortality, showing 11% likelihood relative (HR 0.89, CI:0.80-0.99, 0.027). addition, significant negative linear patients 0.081). further associations on morbidity mortality. Higher associated increased yet inversely correlated patients. These paradoxical underscore need COPD-specific lipid management strategies that balance progression risks.

Language: Английский

---

Inhibition of Inflammatory Regulators for Chronic Obstructive Pulmonary Disease (COPD) Treatment from Indonesian Medicinal Plants: A Systematic Review

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 262 - 262

Published: April 8, 2025

A characteristic of Chronic Obstructive Pulmonary Disease (COPD) is the inflammation respiratory pathway. Inflammatory regulators affected in COPD include cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), interleukin (IL-1β), and interleukin-6 (IL-6). Therefore, this systematic review aimed to investigate biological activity Indonesian medicinal plants as anti-inflammation through vitro, silico, vivo studies. digital search was conducted using Scopus, Google Scholar, PubMed online databases find relevant articles by applying specific keywords related subject interest. The results showed 18 studies that reported five proven inhibit regulation. were sambiloto (Andrographis paniculata), legetan warak (Adenostemma lavenia), kersen (Muntingia calabura), babadotan (Ageratum conyzoides), sembung rambat (Mikania micrantha Kunth). In vitro studies, A. paniculata, lavenia, M. calabura can suppress levels pro-inflammatory cytokines, such TNF-α, IL-1β, IL-6, LPS-stimulated RAW 264.7 cells. silico compounds have strong binding bind inflammatory receptors are andrographiside contained paniculata; ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid lavenia; 7-Hydroxyflavone calabura; 22,23-Dihydrospinasterol conyzoides. extracts calabura, conyzoides, reduce lung tissue animal models (hamsters, mice, rats). This might help develop treatment build scientifically natural products from for future investigations.

Language: Английский

---

Relationship of BMI with Severity of Chronic Obstructive Pulmonary Disease (COPD)

Pakistan Journal of Health Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 206 - 210

Published: March 31, 2025

COPD is linked to significant extra-pulmonary manifestations. However, limited research exists on relationship between BMI and severity. Objective: To find frequency of stages compare mean in various COPD. Methods: This cross-sectional study was conducted at Chest Medicine Department, Mayo hospital, Lahore from August 2022, February 2023 after approval synopsis CPSP. 160 patients were enrolled, classification as per GOLD guidelines calculated. Data analyzed using SPSS version 26.0, comparison across done ANOVA post Hoc analysis done, p-value ≤ 0.05 considered statistically significant. Results: Among individuals, 26.2% had Stage I, 23.8% stage II, while III IV observed 25% each. Mean 24.30 ± 2.71, 25.86 5.77, 20.29 5.39, 19.50 6.07 I-IV, P<0.001. difference when comparing Stage, I vs. (p = 0.003), < 0.001), II 0.001). not 0.900). Conclusions: The distribution severity relatively even all stages, with comparable proportion each stage. A decline increasing disease These findings emphasize the importance regular monitoring patients, lower progression poorer clinical outcomes.

Language: Английский

---

Role of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease Pathogenesis: Updates and Perspectives

Immuno, Journal Year: 2025, Volume and Issue: 5(2), P. 13 - 13

Published: April 15, 2025

Chronic obstructive pulmonary disease (COPD) is a chronic, debilitating condition that affects the lungs and airways. It characterized by persistent bronchitis, exemplified inflammation of bronchial tubes, hypersecretion mucus, emphysema, destruction airway parenchyma. The combination these conditions leads to tissue damage, fibrosis, ongoing inflammatory response in COPD complex process orchestrated wide range immune cells. These include lung epithelial cells, monocytes, macrophages, neutrophils, eosinophils, T B lymphocytes, among others. cells work together produce biomarkers are involved pathogenesis COPD. Some key have been identified variety cytokines, C-reactive protein/serum albumin ratio, fibrinogen, soluble receptor for advanced glycation endproducts, club/clara with molecular weight 16 kDa, surfactant protein D, adiponectin, reactive oxygen species, proteases. This review aims provide comprehensive overview role development progression will delve into intricacies COPD, exploring various cell types this process. By understanding underlying mechanisms drive we can better develop targeted treatments help alleviate symptoms

Language: Английский

---

Regulation of lung inflammation by adiponectin

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 1, 2023

Adiponectin is an insulin sensitizing hormone that also plays a role in the regulation of inflammation. Although adiponectin can exert pro-inflammatory effects, more studies have reported anti-inflammatory even non-adipose tissues such as lung. Obesity considered inflammatory disease, risk factor for lung diseases, and associated with decreased levels plasma adiponectin. The results recent suggested exerts activity chronic obstructive pulmonary asthma invasive fungal infection. signaling receptors adiponectin, AdipoR1 AdipoR2, are expressed by epithelial cells, endothelial immune cells In this mini-review, we discuss mechanisms tissues.

Language: Английский

---