Beneficial Oxidative Stress-Related trans-Resveratrol Effects in the Treatment and Prevention of Breast Cancer

Applied Sciences, Journal Year: 2021, Volume and Issue: 11(22), P. 11041 - 11041

Published: Nov. 22, 2021

Resveratrol is one of the most investigated polyphenols for its multiple biological activities and many beneficial effects. These are mainly related to ability scavenge free radicals reduce oxidative stress. has also been shown have stimulate production antioxidant enzymes, which interact with numerous signaling pathways involved in tumor development, possess side effects associated use chemotherapy drugs. In this review article we summarized main discoveries about impact resveratrol can helping prevent, as well adjuvant treating, breast cancer. A brief overview primary sources some approaches improving bioavailability discussed.

Language: Английский

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Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Oncology Letters, Journal Year: 2023, Volume and Issue: 27(2)

Published: Dec. 20, 2023

Curcumin is a plant polyphenol in turmeric root and potent antioxidant. It binds to antioxidant response elements for gene regulation by nuclear factor erythroid 2‑related 2, thereby suppressing reactive oxygen species (ROS) exerting anti‑inflammatory, anti‑infective other pharmacological effects. Of note, curcumin induces oxidative stress tumors. several enzymes tumors, such as carbonyl reductases, glutathione S‑transferase P1 nicotinamide adenine dinucleotide phosphate induce mitochondrial damage, increase ROS production ultimately tumor cell death. However, the instability poor pharmacokinetic profile of in vivo limit its clinical application. Therefore, effects may be enhanced through combination with drugs, derivative development nanocarriers. In present review, mechanisms that death are discussed. addition, methods used enhance antitumor activity described. Finally, existing knowledge on functions particularly terms stress, summarized facilitate future research.

Language: Английский

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Targeting mTOR with curcumin: therapeutic implications for complex diseases

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Language: Английский

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Effects of polyphenols on non-alcoholic fatty liver disease: a case study of resveratrol

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Plant polyphenols show good potential for preventing chronic metabolic diseases, especially resveratrol, by reducing insulin resistance and fat synthesis linked to non-alcoholic fatty liver disease.

Language: Английский

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Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products

Journal of Genetic Engineering and Biotechnology, Journal Year: 2025, Volume and Issue: 23(2), P. 100501 - 100501

Published: May 3, 2025

Language: Английский

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