Recent advancements in natural compounds for cancer therapy and prevention

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Language: Английский

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Gossypol and Its Natural Derivatives: Multitargeted Phytochemicals as Potential Drug Candidates for Oncologic Diseases

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2624 - 2624

Published: Nov. 28, 2022

Despite the vast amounts of research and remarkable discoveries that have been made in recent decades, cancer remains a leading cause death major public health concern worldwide. Gossypol, natural polyphenolic compound derived from seeds, roots, stems cotton (Gossypium hirsutum L.), was first used as male contraceptive agent. Due to its diverse biological properties, including antifertility, antiviral, antioxidant, antibacterial, antimalarial, most notably antitumor activities, gossypol has subject numerous studies. Nevertheless, no systematic review performed analyzes antineoplastic potential related compounds an organ-specific manner while delineating molecular mechanisms action. Hence, we extensive literature search for anticancer properties their derivatives against various types cells utilizing PubMed, ScienceDirect, Google Scholar, Scopus. The sources, distribution, chemical structure, toxicity constituents are briefly reviewed. Based on emerging evidence, exhibit significant effects through modulation different hallmarks signaling pathways. Additionally, synergistic activity with chemotherapeutic agents observed. Our evaluation current suggests multitargeting drug candidates combat multiple human malignancies.

Language: Английский

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Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 40(10-12), P. 636 - 662

Published: July 20, 2023

The nuclear factor erythroid 2-related 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell adaptation to variety exogenous endogenous stressors. Accumulating evidence from the last decade indicates that impairment balance leads oxidative stress (OS), common alteration occurring in many human acute chronic inflammatory diseases, such as cancer, diabetes, neurodegeneration, metabolic disorders, aging.

Language: Английский

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Lactate as Key Metabolite in Prostate Cancer Progression: What Are the Clinical Implications?

Cancers, Journal Year: 2023, Volume and Issue: 15(13), P. 3473 - 3473

Published: July 3, 2023

Advanced prostate cancer represents the fifth leading cause of death in men worldwide. Although androgen-receptor signaling is major driver disease, evidence accumulating that disease progression supported by substantial metabolic changes. Alterations de novo lipogenesis and fatty acid catabolism are consistently reported during development association with signaling. Therefore, term "lipogenic phenotype" frequently used to describe complex rewiring occurs cancer. However, a new scenario has emerged which lactate may play role. oncogenes/tumor suppressors, androgen signaling, hypoxic conditions, cells tumor microenvironment can promote aerobic glycolysis release microenvironment, favoring immune evasion metastasis. As composed metabolically heterogenous cells, glycolytic or cancer-associated fibroblasts also secrete create "symbiotic" interactions oxidative via shuttling sustain progression. Here, we discuss multifaceted role progression, taking into account influence systemic gut microbiota. We call special attention clinical opportunities imaging accumulation for patient stratification targeting metabolism.

Language: Английский

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Mcl-1 Protein and Viral Infections: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1138 - 1138

Published: Jan. 17, 2024

MCL-1 is the prosurvival member of Bcl-2 family. It prevents induction mitochondria-dependent apoptosis. The molecular mechanisms dictating host cell viability gain importance in context viral infections. premature apoptosis infected cells could interrupt pathogen replication cycle. On other hand, death following effective assembly progeny particles may facilitate virus dissemination. Thus, various viruses can interfere with regulation network to their advantage. Research has shown that infections affect intracellular amount modify apoptotic potential cells, fitting it “schedule” A growing body evidence suggests virus-dependent deregulation level contribute several virus-driven diseases. In this work, we have described role caused by viruses. We also presented a list promising antiviral agents targeting protein. discussed results indicate targeted interventions addressing anti-apoptotic MCL1 as new therapeutic strategy for cancers well investigation cellular and involved engaging better understanding survival balance.

Language: Английский

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Bioelectric pharmacology of cancer: A systematic review of ion channel drugs affecting the cancer phenotype

Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: 191, P. 25 - 39

Published: July 5, 2024

Language: Английский

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Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy

Strahlentherapie und Onkologie, Journal Year: 2023, Volume and Issue: 199(12), P. 1091 - 1109

Published: April 11, 2023

Abstract Recent advances in understanding the tumor’s biology line with a constantly growing number of innovative technologies have prompted characterization patients’ individual malignancies and may display prerequisite to treat cancer at its patient tumor vulnerability. In recent decades, radiation- induced signaling promoting local events for radiation sensitization were explored detail, resulting development novel molecular targets. A multitude pharmacological, genetic, immunological principles, including small molecule- antibody-based targeted strategies, been developed that are suitable combined concepts (RT) or chemoradiation therapy (CRT). Despite plethora promising experimental preclinical findings, however, so far, only very limited clinical trials demonstrated better outcome and/or benefit when RT CRT agents. The current review aims summarize progress therapies targeting oncogenic drivers, DNA damage cell cycle response, apoptosis pathways, adhesion molecules, hypoxia, microenvironment impact refractoriness boost response. addition, we will discuss nanotechnology, e.g., RNA protein-degrading proteolysis-targeting chimeras (PROTACs) open new ways from molecular-targeted approaches improved efficacy.

Language: Английский

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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2023, Volume and Issue: 32(1), P. 19 - 47

Published: Sept. 27, 2023

Cancer is a leading cause of death globally, with limited treatment options and several limitations. Chemotherapeutic agents often result in toxicity which long-term conventional treatment. Phytochemicals are natural constituents that more effective treating various diseases less than the chemotherapeutic providing alternative therapeutic approaches to minimize resistance. These phytoconstituents act ways deliver optimum effectiveness against cancer. Nevertheless, phyto-formulations management cancers may be constrained due challenges related inadequate solubility, bioavailability, stability. Nanotechnology presents promising avenue for transforming current cancer methods through incorporation phytochemicals into nanosystems, possess range advantageous characteristics such as biocompatibility, targeted sustained release capabilities, enhanced protective effects. This holds significant potential future advancements management. Herein, this review aims provide intensive literature on diverse nanocarriers, highlighting their applications cargos phytocompounds Moreover, it offers an overview respective field, emphasizing contribute favourable outcomes both vitro vivo settings. Lastly, clinical development regulatory concerns also discussed check transformation concept strategy combination therapy chemotherapeutics could lead future.

Language: Английский

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DoubleSG-DTA: Deep Learning for Drug Discovery: Case Study on the Non-Small Cell Lung Cancer with EGFRT790M Mutation

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 675 - 675

Published: Feb. 16, 2023

Drug–targeted therapies are promising approaches to treating tumors, and research on receptor–ligand interactions for discovering high-affinity targeted drugs has been accelerating drug development. This study presents a mechanism-driven deep learning-based computational model learn double sequences, protein graphs project drug–target affinities (DTAs), which was termed the DoubleSG-DTA. We deployed lightweight graph isomorphism networks aggregate representations discriminate between molecular structures, stacked multilayer squeeze-and-excitation selectively enhance spatial features of sequences. What is more, cross-multi-head attentions were constructed further non-covalent docking behavior. The multiple cross-validation experimental evaluations various datasets indicated that DoubleSG-DTA consistently outperformed all previously reported works. To showcase value DoubleSG-DTA, we applied it generate hit compounds Non-Small Cell Lung Cancer harboring EGFRT790M mutation from natural products, consistent with laboratory studies. Afterward, investigated interpretability graph-based “black box” highlighted active structures contributed most. thus provides powerful interpretable framework extrapolates potential chemicals modulate systemic response disease.

Language: Английский

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Inhibition of platin-induced BCL2 increase overcomes chemoresistance in squamous cell carcinoma of the head and neck through resensitization to cell death

Translational Oncology, Journal Year: 2025, Volume and Issue: 53, P. 102308 - 102308

Published: Feb. 18, 2025

Language: Английский

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