Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(9)

Published: Sept. 14, 2023

Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring that, ultimately, affect lung compliance capacity. As result of its broad range biological activities, including antioxidant, anti-inflammatory, antiapoptotic, many others, resveratrol has been shown to be an effective treatment for respiratory system disease, infectious cancer. This work reviews the known molecular therapeutic targets potential mechanisms action attenuating PF cancer, COVID-19, diseases (ILDs) etiologies, idiopathic pneumonia, ILDs associated with systemic disorders, such as rheumatoid arthritis, sclerosis, Schrödinger’s syndrome, lupus erythematosus, hypertension. The current issues controversies related possible use pharmaceutical drug or supplement also discussed.

Language: Английский

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Contributions of Common Foods to Resveratrol Intake in the Chinese Diet

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1267 - 1267

Published: April 21, 2024

Resveratrol is a polyphenolic compound with antioxidant and anti-inflammatory properties therefore has potential health benefits for the prevention treatment of wide range diseases, including cardiovascular disease, cancer, diabetes, neurodegenerative diseases. The beneficial dose resveratrol between 30 150 mg. Although have been extensively studied, intake through diet residents in China remains unclear, which restricts development resveratrol-rich foods. In this study, dietary assessment was conducted to reveal that daily by Chinese common foods only 0.783 mg, significantly below dose. Among main food types, fruits emerged as primary source resveratrol, contributing 88.35% total intake. To improve intake, methods increase its consumption were proposed. First method content peanuts. addition, can be extracted from peels. It also recommended adopt technical means bioavailability develop related supplements functional drinks.

Language: Английский

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Resveratrol Food Supplement Products and the Challenges of Accurate Label Information to Ensure Food Safety for Consumers

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 474 - 474

Published: Jan. 16, 2023

The food supplement market is growing as many consumers wish to complement their nutrient intake. Despite all the regulations in place ensure supplements safety, there are still cases of irregularities reported especially connected internet sales. Twenty resveratrol products sold on Slovenian were evaluated compliance declared vs. determined content, well labels with European Union (EU) and regulatory requirements. Both ingredient contents information important parts safety. Analyses 20 performed using high-performance thin-layer chromatography (HPTLC) coupled densitometry showed that 95% had different from what was 55% contained higher than declared. In 25% content per unit exceeded maximum level (150 mg/day) specified EU novel conditions for trans-resveratrol. Evaluation included mandatory voluntary information, health claims nutrition claims. Most necessary but multiple errors observed ranging typos misleading practices. From a safety perspective lot improvement needed field supplements.

Language: Английский

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Resveratrol Bioavailability After Oral Administration: A Meta‐Analysis of Clinical Trial Data

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Annually, a growing body of studies substantiates the health advantages polyphenolic compounds, yet their practical application is constrained by swift metabolism and low bioavailability. Resveratrol, stilbene derivative showcasing typical traits, particularly noteworthy. Despite abundant bioavailability data from in vitro animal studies, applying these findings to humans demands nuanced consideration. The objective this article conduct meta‐analysis on clinical trial data, systematically assessing oral resveratrol deriving meaningful insights into its efficacy humans. To achieve goal, we thoroughly examined publications across five major global databases: PubMed, Cochrane Library, Scopus, Embase, Science Direct. study exclusively included trials involving healthy adults, where pharmacokinetic parameters were measured following administration at least one dose as single preparation. For extraction, mean score standard deviation (SD) included. Heterogeneity, degree inconsistency between meta‐regression assessed. From searches, scrutinized 84 administrations encompassing nine doses ranging 25 5000 mg. Our indicate linear increase amount free entering bloodstream with administered dose, while T max values remain unaffected. maximum plasma concentration (31.07 ng/mL) closely mirrors C observed group medium 100 500 mg (33.59 ng/mL). This similarity implies appropriateness employing specific resveratrol, taking consideration both very risk potential side effects. However, analysis available human methodological inconsistencies prevalent existing studies. underscores substantial heterogeneity, underscoring imperative for multiple rectify prevailing trend.

Language: Английский

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Wine-Making; “with one Stone Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products

Published: June 14, 2023

The plethora of bio-functional compounds present in fermented alcoholic beverages like wine, as well the valorization bioactives from their wineries/breweries by-products grape pomace and seed, has gained significant interest functional foods sector. Wine always accompanied humanity, for religion or health. For example, Christians are using wine “Holy Communion”, following what Jesus Christ himself did said during Last Supper, while benefits consumption moderation was embedded all Mediterranean civilizations, it is mentioned by wise King-Prophet David his psalms, but also Hip-pocrates other men, a Greek-based philosophy “All things Moderation” (Cleobulus Lindos; 6th century BC). In modern times, after outbreak research on since 90’s, when term “French Paradox” introduced US public CBS show, recent evidence outlined that these derived synergisms its digestion-derived metabolites. Within this article, proposed health moderate consumption, component balanced diet (i.e. Mediterra-nean Diet), against inflammation-related chronic disorders, thoroughly reviewed. various both wineries’ by-products, such bioactive phe-nolics, unsaturated fatty acids, polar lipids, dietary fibers, antioxidant, anti-inflammatory antithrombotic promoting properties evaluated. mechanisms actions synergism, which elicited, ex-plored. Functional non-alcoholic products introduced. Emphasis given to applications bioactives, ingredients foods, supplements nutraceuticals. Limitations future perspectives popular beverage (wine) ant rich addressed. .

Language: Английский

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Effects of Resveratrol on In Vivo Ovarian Cancer Cells Implanted on the Chorioallantoic Membrane (CAM) of a Chicken Embryo Model

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4374 - 4374

Published: April 16, 2024

Ovarian cancer poses a significant threat to patients in its advanced stages, often with limited treatment options available. In such cases, palliative management becomes the primary approach maintaining reasonable quality of life. Therefore, administration any medication that can benefit without curative option holds potential. Resveratrol, natural compound known for vitro anticancer activities, has generated contrasting results vivo and human studies. this study, we aimed assess effects resveratrol on ovarian cells grown chorioallantoic membrane (CAM) chicken embryos. Two cell lines, OVCAR-8 SKOV-3, were cultured collagen scaffolds four days before being implanted CAM embryos day 7. Different doses applied every two six days. Subsequently, tissues excised, fixed, subjected histological analysis. Some tumours extracted analyse proteins through Western blotting. Our findings indicate specific significantly reduce angiogenic pNF-κB levels, SLUG protein levels by using immunohistochemistry. These suggest may have potential impact behaviour tumours, thereby warranting further consideration as complementary women incurable cancer.

Language: Английский

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Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Processes, Journal Year: 2024, Volume and Issue: 12(6), P. 1216 - 1216

Published: June 13, 2024

Resveratrol is a natural compound that can be found in red wine, grapes, and berries. It has attracted attention due to its potential health benefits. The aim of this review was align ways retaining resveratrol contents berries products made berries, show which agricultural processing techniques maximize the content their how achieved. scientific literature revealed concentration berry-derived varies significantly depending on source applied. range from 0.03–0.06 mg/kg blueberries 5–10 grape skins. Agricultural such as controlled water stress (e.g., increasing grapes 8.3–11.5 mg/kg), optimal sun exposure enhancing 1.5–2.1 balanced nutrient management, selecting high-resveratrol cultivars up 15 certain grapes) substantially increase content. Processing methods like cold pressing, centrifugation, ultrafiltration, freeze-drying are effective preserving levels, while traditional pasteurization tends reduce concentration. For instance, high-temperature short-time juice 1.5 0.8 mg/kg, whereas pressing retains more (1.5 1.4 mg/kg). By optimizing these techniques, manufacturers enhance products, meeting growing consumer demand for health-enhancing supporting healthier society. This approach aligns with commitment overcoming technical challenges associated use, ensuring fully realized both health-related non-health-related applications.

Language: Английский

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Pharmacokinetic Profiles of Melinjo Seed Extract Components in Rats

ACS Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Melinjo (Gnetum gnemon L.) seeds are rich in resveratrol (RES) and its dimers, gnetin C gnemonoside A. They have various pharmacological benefits, antioxidant anti-inflammatory properties; however, their pharmacokinetics, especially animal models, must be better understood. This study aimed to elucidate the pharmacokinetics of melinjo seed extract (MSE) components rats. Plasma samples were collected up 24 h after intergastric administration MSE (1000 mg/kg), C, or A (51 μmol/kg each). RES was present as conjugates, with maximum plasma concentration (1065 nM) achieved at 6 postadministration MSE. The concentrations following sustained, absorption rates, based on AUC–dose relationship, reached 13.7 4.8%, respectively, higher than that each standard alone. These findings indicate enhances derivatives, potentially supporting therapeutic applications functional foods.

Language: Английский

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Effect of oral resveratrol-loaded nanoliposomes on hyperlipidemia via toll-like receptor 3 and TIR domain-containing adaptor inducing interferon-β protein expression in an animal model

Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: March 18, 2025

Hyperlipidemia, a critical risk factor for various health conditions, necessitates innovative therapeutic strategies. Investigating the effectiveness of liposomal formulations in managing hyperlipidemia is essential. Resveratrol (RES)-loaded nanoliposomes present promising new approach treatment. In this study, we investigated anti-hyperlipidemic potential RES-loaded high-fat diet (HFD)-fed rats. The were prepared using thin-film hydration method. According to transmission electron microscopy (TEM) and dynamic light scattering (DLS) results, mean size about 42 nm 68 nm, respectively, with zeta -65.6 mV. entrapment efficiency loading content 83.78% 14.25%, respectively. Additionally, exhibited controlled release kinetics compared free RES form. Moreover, hyperlipidemic rat model induced by an HFD, orally administered significantly reduced total cholesterol (TC), low-density lipoprotein (LDL-C), very (VLDL-C), triglycerides (TG), while concurrently increasing high-density (HDL-C) levels. liver damage HFD was alleviated nanoliposomes. expression levels Toll-like receptor 3 (TLR3) TIR domain-containing adaptor-inducing interferon-β (TRIF) assessed fluorescence immunohistochemistry. Notably, these protein. effect measured on body weight rats, demonstrting hold promise management. These findings underscore as safe effective option hyperlipidemia.

Language: Английский

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Resveratrol: Recent Advances and Applications in Functional and Nutraceutical Foods

Royal Society of Chemistry eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 149 - 164

Published: April 11, 2025

Foods designed and consumed for purposes other than meeting basic nutritional requirements are referred to as functional foods. Resveratrol is a stilbenoid that can be found cis- trans-resveratrol stereoisomers of the central ethylene moiety in its structure. involved lipid peroxidation, protein oxidation, DNA resveratrol scavenging mechanisms, reduction ROS/RNS production, intracellular antioxidant defense systems, signaling pathway regulation; furthermore, it also plays role both direct indirect mechanisms. Although research focuses on different mechanisms health effects related resveratrol, main due stability solubility trans-resveratrol. Moreover, many external factors, such light, air exposure, oxidative enzymes, pH, temperature, might have

Language: Английский

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