Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1283 - 1283
Published: Sept. 27, 2024
As a primary source of mortality and disability, bacterial infections continue to develop severe threat humanity. Nuclear medicine imaging (NMI) is known for its promising potential diagnose deep-seated infections. This work aims new technetium-99m (
Language: Английский
Journal of Cancer, Journal Year: 2023, Volume and Issue: 14(14), P. 2700 - 2706
Published: Jan. 1, 2023
AimsThe aim of this study was to investigate the anti-tumor efficacy brucine on intrahepatic cholangiocarcinoma (ICC).Methods ICC QBC939 cells were treated with brucine, cell viability, cycle and apoptosis analyzed using CCK-8 flow cytometry.The expression COX-2 related proteins Casp3, Bax Bcl-2 detected by Western blot analysis.QBC939 subcutaneously transplanted into nude mice injected intraperitoneally.The Ki67, immunohistochemical staining analysis.Results Brucine significantly inhibited proliferation progression while promoted cells.The apoptotic Casp3 upregulated, downregulated in treatment.Moreover, overexpression could antagonize effects cells.In vivo, subcutaneous tumor formation mice, decreased increased tissues from treatment.Conclusions can inhibit vitro mechanism may be inhibition expression.
Language: Английский
Citations
2
Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(2), P. 77 - 77
Published: Feb. 7, 2024
Equine melanocytic tumors are common and have an unusual benign behavior with low invasiveness metastatic rates. However, tumoral mass growth is usually a concern that can life-threatening consequences. COX-2 related to oncogenesis, promoting neoplastic cell proliferation, invasion, metastasis. The aim of this study was evaluate the immunohistochemical expression in equine tumors. Through extension intensity labeling, 39 melanocytomas 38 melanomas were evaluated. Of malignant tumors, 13.2% negative 63.2% presented expression. Only 6 >50% labeled cells, 18 8 had between 21 50%, 3 20%, 1 tumor 5%, 5 28 no Malignant showed higher than did statistically significant differences. levels may be one molecular reasons for presence expansive instead invasive pattern other species, which high levels.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Fungi are considered to be storehouse of novel biologically and structurally diverse compounds with immense therapeutic potential. Novel moieties have been discovered from fungi subsequently deployed in pharmaceutical industry as antimicrobial, anticancer, neuroprotective, antioxidant moieties. Tremendous research is being carried out the exploration fungal secondary metabolites for anticancer therapy which enzyme inhibitors targets. Various enzymes, viz. histone deacetylase (HDAC), DNA topoisomerases, telomerase, cyclooxygenase (COX-2), angiotensin-converting enzyme, phosphatidylinositol-3-kinase drug targets treatment various tumors. Many molecules belonging different classes organic reported potent anticancerous molecules, but none molecule commercialized due adverse effects. The present chapter will outline enzymes their can exploited effective agents.
Language: Английский
Citations
0
Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(18), P. 1557 - 1588
Published: May 20, 2024
Molecular hybridization is a rational design strategy used to create new ligands or prototypes by identifying and combining specific pharmacophoric subunits from the molecular structures of two more known bioactive derivatives. valuable technique in drug discovery, enabling modulation unwanted side effects creation potential dual-acting drugs that combine multiple therapeutic agents. Indole-triazole conjugates have emerged as promising candidates for development. The indole triazole moieties can be linked through various synthetic strategies, such click chemistry other coupling reactions, generate library diverse compounds biological screening. achievable structural diversity with indole-triazole offers avenues optimize their pharmacokinetic pharmacodynamic attributes, amplifying efficacy. Researchers extensively tailored both frameworks modifications comprehend impact on drug's characteristics. current review article endeavours explore discuss research strategies indoletriazole hybrids elucidate significance variety pathological conditions. insights provided herein are anticipated beneficial researchers will likely encourage further exploration this field.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1283 - 1283
Published: Sept. 27, 2024
As a primary source of mortality and disability, bacterial infections continue to develop severe threat humanity. Nuclear medicine imaging (NMI) is known for its promising potential diagnose deep-seated infections. This work aims new technetium-99m (
Language: Английский
Citations
0