Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota DOI Creative Commons
Jing Li, Y. Xu, Tianhao Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Nephrotic syndrome (NS) represents a prevalent among various chronic kidney disease pathologies and is known for its higher severity worse prognosis compared with glomerulonephritis. Understanding pathogenesis identifying more effective treatment modalities have long been concern of specialists. With the introduction gut-kidney axis concept progress in omics technologies, alterations gut microbiota observed primary secondary NS. This link has extensively researched conditions such as diabetic nephropathy immunoglobulin A (IgA) nephropathy. Thus, dysbiosis seen crucial contributing factor NS; however, there lack comprehensive reviews that elucidate changes across different NS describe mechanistic role disease. Moreover, serving an innate regulator microbiota, traditional Chinese medicine (TCM) potential to exert profound impact on expression inflammation-promoting agents, decreasing levels endotoxins uremic toxins. In addition, it strengthens stability intestinal barrier while controlling metabolic function body through efficient modulation microbiota. intricate process yields far-reaching consequences

Language: Английский

Transcriptomics Reveals Effect of Pulsatilla Decoction Butanol Extract in Alleviating Vulvovaginal Candidiasis by Inhibiting Neutrophil Chemotaxis and Activation via TLR4 Signaling DOI Creative Commons
Hui Wu, Can Li,

Yemei Wang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 594 - 594

Published: May 7, 2024

The Pulsatilla decoction is a well-known herbal remedy used in clinical settings for treating vulvovaginal candidiasis (VVC). However, the specific mechanism that makes it effective still unclear. Recent studies have shown cases of VVC, neutrophils recruited to vagina, influenced by heparan sulfate (HS), do not successfully engulf

Language: Английский

Citations

4
Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents DOI

Changxu Lu,

Jinwen Wei,

Can Gao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113373 - 113373

Published: Nov. 19, 2024

Language: Английский

Citations

4
Metabolomics combined with network pharmacology reveals the protective effect of astragaloside IV on alcoholic liver disease DOI
Jinfang Hao,

Ruixian Hu,

Jianming Zhao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 156032 - 156032

Published: Sept. 1, 2024

Language: Английский

Citations

2
Multi-omics analysis to reveal the synergistic mechanism underlying the multiple ingredients of Stephania tetrandra extract on rheumatoid arthritis through the PI3K/Akt signaling pathway DOI Creative Commons

Jinfeng Chen,

An Zhang,

Anzheng Nie

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 16, 2024

Background: Stephania tetrandra has been used for treating rheumatic diseases thousands of years in rural areas China. Several studies have found that tetrandrine and fangchinoline can inactivate the PI3K/Akt signaling pathway by reducing expression phosphorylation AKT. However, mechanism underlying therapeutic actions S. on RA is not well known. Methods: In this study, we determined molecular effects multiple ingredients extract (STE) collagen-induced arthritic (CIA) rats integrating pharmacometabolomics, proteomics, PTMomics. Results: multi-omics joint analysis, first, signatures proteins, PTMs, metabolites, STE were profiled CIA PBMCs underwent treatment. Bioinformatics analysis subsequently probed mainly regulated tryptophan metabolism, inflammatory response, cell adhesion pathways rats. The interrelated further constructed, findings revealed attenuated response proliferation mediating key targets pathway, including Hint1, ACP1, FGR, HSP90@157W + dioxidation, Prkca@220N 845.4540 Da. functions Hint1 ACP1 confirmed applying a transcriptomic data patients who clinically received abatacept therapy. Furthermore, cross-ome correlation was performed major vivo STE, coclaurine- N -glucuronide, Me,coclaurine- O -glc, -gluA-schefferine, corydamine, corypamine, tetrandrine, fangchiniline, to act these targerts pathway. Conclusion: These results elucidated which mediate leading anti-rheumatic functions. study provided new insights into synergistic effect against arthritis

Language: Английский

Citations

0
Metabolomics revealed pharmacodynamic effects of aspirin and indobufen in patients after percutaneous transluminal angioplasty surgery DOI Creative Commons

Shaobo Sun,

Kang Xun,

Damei Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 29, 2024

Aspirin and indobufen are commonly used therapeutic drugs for the prevention of vascular restenosis (VR) after percutaneous transluminal angioplasty surgery. They both exhibited antiplatelet effects but molecular mechanisms underlying metabolic changes induced by them remain unclear.

Language: Английский

Citations

0
Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota DOI Creative Commons
Jing Li, Y. Xu, Tianhao Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Nephrotic syndrome (NS) represents a prevalent among various chronic kidney disease pathologies and is known for its higher severity worse prognosis compared with glomerulonephritis. Understanding pathogenesis identifying more effective treatment modalities have long been concern of specialists. With the introduction gut-kidney axis concept progress in omics technologies, alterations gut microbiota observed primary secondary NS. This link has extensively researched conditions such as diabetic nephropathy immunoglobulin A (IgA) nephropathy. Thus, dysbiosis seen crucial contributing factor NS; however, there lack comprehensive reviews that elucidate changes across different NS describe mechanistic role disease. Moreover, serving an innate regulator microbiota, traditional Chinese medicine (TCM) potential to exert profound impact on expression inflammation-promoting agents, decreasing levels endotoxins uremic toxins. In addition, it strengthens stability intestinal barrier while controlling metabolic function body through efficient modulation microbiota. intricate process yields far-reaching consequences

Language: Английский

Citations

0