The Antitumor Potential of Sicilian Grape Pomace Extract: A Balance between ROS-Mediated Autophagy and Apoptosis DOI Creative Commons

Federica Affranchi,

Diana Di Liberto, Marianna Lauricella

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1111 - 1111

Published: Sept. 3, 2024

From the perspective of circular economy, it is extremely useful to recycle waste products for human health applications. Among health-beneficial properties bioactive phyto-compounds, grape pomace represents a precious source molecules with potential antitumor properties. Here, we describe effects Sicilian hydroalcoholic extract (HE) in colon and breast cancer cells. The characterization HE composition revealed predominance anthoxanthins phenolic acids. treatment was more effective reducing viability cells, while cells appeared resistant. Indeed, underwent apoptosis, as shown by DNA fragmentation, caspase-3 activation, PARP1 degradation, seemed not undergo apoptosis. To elucidate underlying mechanisms, reactive oxygen species (ROS) were evaluated. Interestingly, ROS increased both cell lines but, cancer, cells' rapidly progressively diminished over time, increase persistent up 24 h. This effect correlated induction pro-survival autophagy, demonstrated autophagosomes formation, autophagic markers increase, protection antioxidant NAC. autophagy inhibitor bafilomycin A1 significantly but Overall, our data provide evidence that efficacy tumor depends on balance between ROS-mediated Therefore, inhibiting may be tool target those appear resistant HE.

Language: Английский

Advances in the application of metal oxide nanozymes in tumor detection and treatment DOI

Chunfang Cheng,

Huixin Wang,

Jingyu Zhao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113767 - 113767

Published: Jan. 24, 2024

Language: Английский

Citations

57
Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance DOI Open Access
Chao Gu, Xueliang Liu,

Luo Lei

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(50)

Published: Nov. 3, 2023

Chemo-dynamic therapy (CDT) based on the Fenton or Fenton-like reaction has emerged as a promising approach for cancer treatment. However, autophagy-mediated self-protection mechanisms of cells pose significant challenge to efficacy CDT. Herein, we developed metal-DNA nanocomplexes (DACs-Mn) enhance CDT via DNAzyme inhibition autophagy. Specifically, Mn-based catalyst in DACs-Mn was used generate highly hydroxyl radicals (⋅OH) that kill cells, while ATG5 incorporated into inhibited expression autophagy-associated proteins, thereby improving By disrupting self-protective pathway under severe oxidative stress, this novel found synergistically both vitro and vivo models, effectively amplifying tumor-specific damage. Notably, Metal-DNA can also induce immunogenic cell death (ICD), inhibiting tumor metastasis. bilateral model mice, combined autophagy followed by immune checkpoint blockade shown potential effective treatment modality primary metastatic tumors.

Language: Английский

Citations

28
Advanced Delivery System of Polyphenols for Effective Cancer Prevention and Therapy DOI Creative Commons

Koung Hee Kim,

Mi‐Ran Ki, Ki Ha Min

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1048 - 1048

Published: May 5, 2023

Polyphenols from plants such as fruits and vegetables are phytochemicals with physiological pharmacological activity potential drugs to modulate oxidative stress inflammation associated cardiovascular disease, chronic cancer. However, due the limited water solubility bioavailability of many natural compounds, their applications have been limited. Researchers made progress in development nano- micro-carriers that can address these issues facilitate effective drug delivery. The currently developed delivery systems maximize fundamental effects various aspects absorption rate, stability, cellular absorption, bioactivity polyphenols. This review focuses on antioxidant anti-inflammatory polyphenols enhanced by introduction systems, ultimately discusses inhibition cancer cell proliferation, growth, angiogenesis.

Language: Английский

Citations

27
Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions DOI Creative Commons
Md. Ataur Rahman, Kazi Rejvee Ahmed,

Farzana Haque

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 428 - 428

Published: Feb. 9, 2023

Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies

Language: Английский

Citations

25
Pathogenesis of Hepatocellular Carcinoma: The Interplay of Apoptosis and Autophagy DOI Creative Commons
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1166 - 1166

Published: April 13, 2023

The pathogenesis of hepatocellular carcinoma (HCC) is a multifactorial process that has not yet been fully investigated. Autophagy and apoptosis are two important cellular pathways critical for cell survival or death. balance between autophagy regulates liver turnover maintains intracellular homeostasis. However, the often dysregulated in many cancers, including HCC. may be either independent parallel one influence other. inhibit promote apoptosis, thus regulating fate cancer cells. In this review, concise overview HCC presented, with emphasis on new developments, role endoplasmic reticulum stress, implication microRNAs gut microbiota. characteristics associated specific disease also described brief description provided. initiation, progress metastatic potential reviewed experimental evidence indicating an interplay extensively analyzed. ferroptosis, recently pathway regulated death, presented. Finally, therapeutic implications drug resistance examined.

Language: Английский

Citations

23
PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review DOI Creative Commons
Peramaiyan Rajendran, Ramya Sekar,

Prabhu Shankar Dhayasankar

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(6), P. 1165 - 1175

Published: Jan. 1, 2024

Oral cancer is the most heterogeneous at clinical and histological levels.PI3K/AKT/mTOR pathway was identified as one of commonly modulated signals in oral cancer, which regulates major cellular metabolic activity cell.Thus, various proteins PI3K/AKT/mTOR were used therapeutic targets for to design more specific drugs with less off-target toxicity.This review sheds light on regulation PI3K/AKT/mTOR, its role controlling autophagy associated apoptosis during progression metastasis squamous type malignancy (OSCC).In addition, we reviewed detail upstream activators downstream effectors signaling potential treatment.

Language: Английский

Citations

14
Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential DOI Creative Commons
Antonio José Cabrera-Serrano, José Manuel Sánchez‐Maldonado, Carmen González‐Olmedo

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 264 - 264

Published: Feb. 25, 2025

Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.

Language: Английский

Citations

1
Ubiquitin-specific peptidase 1: assessing its role in cancer therapy DOI
Peng Huang, Yuhan Wang, Pengfei Zhang

et al.

Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 23(7), P. 2953 - 2966

Published: April 24, 2023

Language: Английский

Citations

16
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma DOI

Lixia Dong,

Li Luo, Zihao Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 220, P. 111 - 124

Published: April 30, 2024

Language: Английский

Citations

5
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy DOI

Kui Wang,

Shuyue Fu,

Lixia Dong

et al.

Autophagy, Journal Year: 2023, Volume and Issue: 19(12), P. 3132 - 3150

Published: July 20, 2023

Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major clinical challenge. Periplocin, bioactive component traditional Chinese herb

Language: Английский

Citations

12