The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12555 - 12555

Published: Aug. 8, 2023

This review explores the emerging role of hydrogen sulfide (H

Language: Английский

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Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1757 - 1757

Published: April 12, 2024

Curcumin is a natural compound with great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, poor water solubility significantly deteriorate clinical use. Many attempts have been made to overcome this issue, encapsulating curcumin in hydrogel matrix may improve those properties. Hydrogel formulation used many drug delivery forms, including classic types novel forms such as self-assembly systems or responsive external factors. Reviewed studies confirmed better properties of hydrogel-stabilized comparison pure compound. The main enhanced characteristics were chemical stability, solubility, which enabled these be tested for various diseases. These formulations evaluated wound healing properties, effectiveness treating skin diseases, anticancer regenerative improved biopharmaceutical opening the opportunity finally see clinically approved substance unravel therapeutic potential.

Language: Английский

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The Impact of Genetics on Cognition: Insights into Cognitive Disorders and Single Nucleotide Polymorphisms

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 156 - 156

Published: Jan. 30, 2024

This article explores the complex relationship between genetics and cognition, specifically examining impact of genetic variants, particularly single nucleotide polymorphisms (SNPs), on cognitive functions development neuropsychiatric disorders. Focusing neurotransmitter regulation within prefrontal cortex’s dopaminergic circuits, this study emphasizes role genes like COMT, PRODH, DRD in shaping executive influencing conditions such as ADHD schizophrenia. Additionally, it significance factors neurodevelopmental disorders, emphasizing need for early identification to guide appropriate therapeutic interventions. also investigates transsulfuration pathway, revealing their association with impairment diseases. Computational analyses, including machine learning algorithms, are highlighted potential predicting symptom severity based variations. In conclusion, underscores intricate interplay environmental outcomes, providing valuable insights tailored treatments a more comprehensive understanding conditions.

Language: Английский

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Effects of Maternal Curcumin Nano-Micelle Supplementation on Transitioning Ewes and Their Offspring: Performance, Health Biomarkers, and Environmental Impacts During Heat Stress

Journal of Thermal Biology, Journal Year: 2025, Volume and Issue: 127, P. 104047 - 104047

Published: Jan. 1, 2025

Language: Английский

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Targeting Epigenetic Plasticity to Reduce Periodontitis-Related Inflammation in Diabetes: CBD, Metformin, and Other Natural Products as Potential Synergistic Candidates for Regulation? A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2853 - 2853

Published: March 21, 2025

Periodontitis is unanimously accepted to be the sixth complication of diabetes mellitus (DM), while inverse relationship causality still deciphered. Among proposed mechanisms gut dysbiosis, which responsible for systemic release proinflammatory mediators. In this process, Gram-negative bacteria from oral cavity enter general circulation, leading emergence bi-hormonal beta-pancreatic cells that lack ability secrete insulin. Additionally, epigenetic and adaptive in affected may play a role reducing inflammation. The reactive oxygen species, cytokines, adipokines, such as interleukins, tumor necrosis factor alpha, leptin, prostaglandin E2, C-reactive protein, or matrix metalloproteinases, determine changes, methylation DNA nucleotides changes activity histone acetylases/deacetylases. management periodontitis involves targeting inflammation, its potential connection modulation observed other chronic conditions help explain preventing DM patients. This review focuses on key might contribute development, explores novel multi-drug therapies could prevent these effects.

Language: Английский

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In silico detection of dysregulated genes and molecular pathways in Alzheimer’s disease as basis for food restoring approach

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19100 - e19100

Published: April 7, 2025

Forty-eight million people worldwide suffer from dementia, often associated with the growth of elderly population. There are also concerns about younger population, where increasing acute and chronic abuse alcohol neurotoxic substances may contribute to brain damage early onset dementia. Alzheimer’s disease (AD) accounts for 60% dementia cases most therapies used so far have been unsuccessful. Genetic, epigenetic vascular factors pathogenesis AD. Among mechanisms, modulation microRNA (miRs) plays an important role. To detect genes pathways involved in AD, we performed original bioinformatic analysis published dysregulated miRs using MIcroRNA ENrichment TURned NETwork (MIENTURNET) followed by Reactome tools. The interrogation these platforms allowed us discover common putative (by MIENTURNET) targeted which set altered tool). Our silico showed that β-catenin phosphorylation cascade Netrin-1 signalling, resulted as significant. Lastly, based on assumption food bioactive compounds (BC) modulate miRs, turn a literature search demonstrated some BC indeed able genes. Curcumin, osthole, puerarin, xanthoceraside, sulforaphane, salvianolic acid A, resveratrol andrographolide lead upregulation Wnt/β-catenin pathway. Choline, methionine, folate vitamin B6/B12 In conclusion, our identified their pathways, paving interesting new insights diagnosis potential therapeutic interventions.

Language: Английский

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Emerging Roles of Histone modifications in Environmental Toxicants-Induced Neurotoxicity

Toxicology, Journal Year: 2025, Volume and Issue: 515, P. 154164 - 154164

Published: April 24, 2025

Language: Английский

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Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17339 - 17339

Published: Dec. 11, 2023

Epigenetic mechanisms play a primary role in the cellular damage associated with brain aging. Histone posttranslational modifications represent intrinsic molecular alterations essential for proper physiological functioning, while divergent expression and activity have been detected several aspects of Aberrant histone methylation has involved neural stem cell (NSC) quiescence, microglial deficits, inflammatory processes, memory impairment, cognitive decline, neurodegenerative diseases, schizophrenia. Herein, we provide an overview recent studies on epigenetic regulation tissue aging, mainly focusing different functional aging process. Emerging targeting strategies are further explored, including neuroprotective drugs, natural compounds, lifestyle therapeutic potential towards process brain.

Language: Английский

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The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3866 - 3866

Published: March 30, 2024

For much of human evolution, the average lifespan was <40 years, due in part to disease, infant mortality, predators, food insecurity, and, for females, complications childbirth. Thus, many females did not reach age menopause (45–50 years age) and it is mainly past several hundred that has been extended >75 primarily public health advances, medical interventions, antibiotics, nutrition. Therefore, underlying biological mechanisms responsible disease risk following must have evolved during complex processes leading Homo sapiens serve functions pre-menopausal state. Furthermore, as a primary function survival species effective reproduction, likely most advantages having such post-menopausal risks relate reproduction ability address environmental stresses. This opinion/perspective will be discussed context how could enhance with improved offspring, perhaps why are preserved. Not all exhibit this set diseases, those who do develop diseases conditions. The state operate unified complex, but independent variables, potential some overlap. there would heterogeneity if factors essential reproductive also concept sets reversible epigenetic changes associated puberty, pregnancy, lactation offered explain observations regarding distribution conditions their roles reproduction. While involvement an system dynamic “modification-demodification-remodification” paradigm contributing hypothesis at point, validation lead better understanding commonalities may future interventions control after menopause.

Language: Английский

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Exploring the Geroprotective Potential of Nutraceuticals

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2835 - 2835

Published: Aug. 24, 2024

Aging is the result of accumulation a wide variety molecular and cellular damages over time, meaning that “the more damage we accumulate, higher possibility to develop age-related diseases”. Therefore, reduce incidence such diseases improve human health, it becomes important find ways combat damage. In this sense, geroprotectors have been suggested as molecules could slow down or prevent diseases. On other hand, nutraceuticals are another set compounds align with need promote health since they biologically active (occurring naturally in food) that, apart from having nutritional role, preventive properties, antioxidant, anti-inflammatory antitumoral, just mention few. present review using specialized databases Scopus PubMed collected information articles published 2010 2023 order describe role during aging process and, given their targeting hallmarks aging, suggest potential be consumed part our regular diet administered additionally supplements.

Language: Английский

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