Journal of Exploratory Research in Pharmacology,
Journal Year:
2023,
Volume and Issue:
8(4), P. 267 - 268
Published: Dec. 14, 2023
The
role
of
nootropic
supplements
is
becoming
increasingly
relevant
in
today's
integrated
therapeutic
landscape.
1The
choice
adjunctive
therapy
complex
because
the
elaborate
nature
drugs
and,
consequently,
potentially
resulting
drug
interactions.The
use
a
nootropic,
although
it
has
an
active
component,
turns
out
to
be
less
disruptive
overall
fewer
interactions
from
its
very
nature;
another
aspect
not
underestimated
general
propensity
patient
take
product
which
he
or
she
does
attribute
exact
as
generally
used
therapy,
and
this
allows
clinician
able
administer
effective
add-on
with
good
compliance
on
part
patient.
2
Among
supplements,
Nosustrophine
important
role.The
effects
supplement
are
manifold,
currently,
found
treatment
Alzheimer's
disease
(AD).Among
pharmacological
interventions,
most
widely
AD
natural
products
(25.6%),
followed
by
anti-amyloid
beta
Clinical Pathology & Research Journal,
Journal Year:
2024,
Volume and Issue:
8(1), P. 1 - 13
Published: Jan. 1, 2024
Previously
we
had
have
reviewed
various
neurodegenerative
diseases
(NDD),
inclusive
of
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
as
well
Huntington’s
(HD),
role
hydrogen
sulfide
(H2
S),
in
treatment
different
cancers
breast
cancer,
glioma,
hepatocellular
carcinoma
along
with
epigenetics
Diabetic
Kidney
Disease
(DKD),
pregnancy.
There
by
the
objective
this
review
is
provision
an
exhaustive
outline
present
research
controlling
epigenetic
events
correlated
NDD.
Here
conducted
a
narrative
utilizing
search
engine
pubmed,
google
scholar;
web
science;
embase;
Cochrane
library
MeSH
terms
like
(NDD);
;
H2
S
disease;
sulfide;
Epigenetics;
DNA
methylation;
Histone
post-translational
modifications;
protein
acetylation;
methylation
from
2000
till
2023
December
date.
Emerging
proof
has
initiated
unravelling
facets
which
impacts
topography
followed
propagation
NDD
AD,
PD),
HD.
possesses
capacity
modulating
crucial
machinery
for
instance
methylation,
histone
modifications
noncoding
RNAs
influencing
gene
expression
cellular
working
germane
to
neuronal
survival,
neuroinflammation,
synaptic
plasticity.
Thus
it
constructed
how
works
form
imperative
actor
amongst
close-knit
network
possessing
probability
opening
innovative
therapeutic
arena.
Although
considerable
work
done,
still
lot
lacunae
exist
on
exact
molecular
modes
plausible
repercussions
H2S
quantities/its
downstream
targets.
Finally
isolation
future
directions
having
using
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(23), P. 25381 - 25389
Published: May 27, 2024
This
study
aimed
to
develop
a
delivery
system
for
the
dried
aqueous
extract
of
Rubia
cordifolia
leaves
(RCE)
that
could
improve
neuroprotective
potential
RCE
by
improving
bioavailability
chief
chemical
constituent
rubiadin.
Rubiadin,
an
anthraquinone
chemically,
is
biomarker
phytoconstituent
RCE.
Rubiadin
reported
have
strong
antioxidant
and
activity
but
demonstrates
poor
bioavailability.
In
order
resolve
problem
related
bioavailability,
phospholipids
were
reacted
in
disparate
ratios
1:1,
1:2,
1:3
prepare
phytosome
formulations
PC1,
PC2,
PC3,
respectively.
The
formulation
PC2
showed
particle
size
289.1
±
0.21
nm,
ζ
−6.92
0.10
mV,
entrapment
efficiency
72.12%,
vitro
release
rubiadin
89.42%
at
pH
7.4
period
up
48
h.
oral
assessed
evaluate
benefit
over
crude
Formulation
relative
134.14%
with
higher
significantly
(p
<
0.05)
augmented
nociceptive
threshold
against
neuropathic
pain
induced
partial
sciatic
nerve
ligation
method.
Antioxidant
enzyme
levels
histopathological
studies
nerves
various
treatment
groups
divulged
has
enough
reverse
damaged
into
normal
state.
Finally,
it
was
concluded
encapsulated
as
carrier
enhancing
efficient
pain.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(11), P. 8675 - 8691
Published: Sept. 30, 2024
Abstract
Cobalamin,
generally
known
as
vitamin
B
12
,
is
a
crucial
component
required
for
humans
in
several
physiological
processes.
It
has
been
produced
from
sources
that
are
derived
animals,
making
it
difficult
vegetarians
and
vegans
to
consume
the
recommended
amount
each
day.
The
importance
of
red
blood
cell
production,
DNA
synthesis,
brain
processes
highlighted.
Recent
studies
have
looked
at
different
methods
producing
such
microbial
fermentation.
Propionibacterium
shermanii
Pseudomonas
denitrificans
demonstrated
remarkable
potential
fermented
.
Compared
conventional
sources,
bioavailability
by
P.
more
effective
meeting
dietary
needs.
Vitamin
can
be
naturally
equipped
with
enzymes
metabolic
pathways
produce
this
vital
vitamin.
fermentation
substrates
improve
nutrient
bioavailability.
generates
during
aid
breakdown
complex
nutrients,
facilitating
easier
absorption
utilization
body.
motive
following
critical
evaluation
assess
advantages
health
capacity
through
Journal of Exploratory Research in Pharmacology,
Journal Year:
2023,
Volume and Issue:
8(4), P. 267 - 268
Published: Dec. 14, 2023
The
role
of
nootropic
supplements
is
becoming
increasingly
relevant
in
today's
integrated
therapeutic
landscape.
1The
choice
adjunctive
therapy
complex
because
the
elaborate
nature
drugs
and,
consequently,
potentially
resulting
drug
interactions.The
use
a
nootropic,
although
it
has
an
active
component,
turns
out
to
be
less
disruptive
overall
fewer
interactions
from
its
very
nature;
another
aspect
not
underestimated
general
propensity
patient
take
product
which
he
or
she
does
attribute
exact
as
generally
used
therapy,
and
this
allows
clinician
able
administer
effective
add-on
with
good
compliance
on
part
patient.
2
Among
supplements,
Nosustrophine
important
role.The
effects
supplement
are
manifold,
currently,
found
treatment
Alzheimer's
disease
(AD).Among
pharmacological
interventions,
most
widely
AD
natural
products
(25.6%),
followed
by
anti-amyloid
beta
