Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview DOI Creative Commons
Elsie Neo Seane, Shankari Nair, Charlot Vandevoorde

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 602 - 602

Published: May 8, 2024

Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results solid tumours when used monotherapy. As a result, combination therapies either radiation or other deoxyribonucleic acid (DNA) damaging agents been suggested ideal strategy to improve their efficacy tumours. Numerous vitro vivo studies demonstrated that HDACis can sensitise malignant cells both electromagnetic particle types of by inhibiting DNA damage repair. Although the radiosensitising ability has reported early 1990s, mechanisms radiosensitisation are yet be fully understood. This review brings forth various protocols sequence administration HDACi treatments different studies. The possible contribution these ambiguity surrounds is also highlighted.

Language: Английский

Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview DOI Open Access
Elsie Neo Seane, Shankari Nair, Charlot Vandevoorde

et al.

Published: April 2, 2024

Histone deacetylases inhibitors (HDACi) have shown promising therapeutic outcomes in haematological malignancies such as leu-kaemia, multiple myeloma and lymphoma, with dis-appointing results solid tumours when used monotherapy. As a result, combination therapies either radiation or other deoxyribonucleic acid (DNA) damaging agents been suggested ideal strategy to improve their efficacy tumours. Numerous vitro vivo studies demonstrated that HDACi can sensitise malignant cells both electromagnetic particle types of by inhibiting DNA damage repair. Although the radiosensitising ability has reported early 1990s, mechanisms radiosensitisation are yet be fully understood. This review brings forth various protocols sequence administration treatments different studies. The possible contribution these on ambiguity surrounds is also highlighted.

Language: Английский

Citations

0
Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview DOI Creative Commons
Elsie Neo Seane, Shankari Nair, Charlot Vandevoorde

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 602 - 602

Published: May 8, 2024

Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results solid tumours when used monotherapy. As a result, combination therapies either radiation or other deoxyribonucleic acid (DNA) damaging agents been suggested ideal strategy to improve their efficacy tumours. Numerous vitro vivo studies demonstrated that HDACis can sensitise malignant cells both electromagnetic particle types of by inhibiting DNA damage repair. Although the radiosensitising ability has reported early 1990s, mechanisms radiosensitisation are yet be fully understood. This review brings forth various protocols sequence administration HDACi treatments different studies. The possible contribution these ambiguity surrounds is also highlighted.

Language: Английский

Citations

0