Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(3), P. 688 - 721

Published: Feb. 3, 2024

Language: Английский

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Chitosan Hydrogels for Water Purification Applications

Gels, Journal Year: 2023, Volume and Issue: 9(8), P. 664 - 664

Published: Aug. 17, 2023

Chitosan-based hydrogels have gained significant attention for their potential applications in water treatment and purification due to remarkable properties such as bioavailability, biocompatibility, biodegradability, environmental friendliness, high pollutants adsorption capacity, capacity. This article comprehensively reviews recent advances chitosan-based hydrogel materials applications. The synthesis methods, structural properties, performance of are critically analyzed. incorporation various nanomaterials into hydrogels, nanoparticles, graphene, metal-organic frameworks, has been explored enhance performance. mechanisms purification, including adsorption, filtration, antimicrobial activity, also discussed detail. the removal pollutants, heavy metals, organic contaminants, microorganisms, from sources is highlighted. Moreover, challenges future perspectives illustrated. Overall, this provides valuable insights current state art regarding highlights addressing global pollution challenges.

Language: Английский

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Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2696 - 2696

Published: Sept. 8, 2023

Biomaterials are mostly any natural and synthetic materials which compatible from a biological point of view with the human body. widely used to sustain, increase, reestablish or substitute function injured tissue organ Additionally, biomaterials uninterruptedly in contact body, i.e., tissue, blood fluids. For this reason, an essential feature is their biocompatibility. Consequently, review summarizes classification different types based on origin, as ones. Moreover, advanced applications pharmaceutical medical domains highlighted specific mechanical physical properties biomaterials, concerning use. The high-priority challenges field also discussed, especially those regarding transfer implementation valuable scientific results practice.

Language: Английский

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Role of Chitosan Hydrogels in Clinical Dentistry

Gels, Journal Year: 2023, Volume and Issue: 9(9), P. 698 - 698

Published: Aug. 29, 2023

Biopolymers are organic polymers that can be treated into intricate designs with porous characteristics mimic essential biologic components. Due to their superior biosafety, biodegradability, biocompatibility, etc., they have been utilized immensely in biomedical engineering, regeneration, and drug delivery. To obtain the greatest number of results, a literature search was undertaken scientific engines utilizing keywords. Chitosan is used variety medical sectors, goal emphasizing its applications benefits clinical dental industry. dissolved liquid form combined other substances create products, including fibers, hydrogels, membranes, microspheres, resins, sponges, pastes, tablets, micro granules. has studied applications. prevention caries wear, pulpotomy accelerate osteogenesis guided tissue regeneration due hemostatic property, primarily benefit from antimicrobial activity by adding it materials, such as glass ionomer cement, calcium hydroxide, adhesive systems. With antibacterial chitosan leading pack promising ingredient production materials. The current review provides an update on background, fundamentals, wide range uses gels science.

Language: Английский

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Production of galactan phthalates derivatives extracted from Gracilaria birdie: Characterization, cytotoxic and antioxidant profile

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 243, P. 125254 - 125254

Published: June 7, 2023

Language: Английский

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In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 357 - 357

Published: July 8, 2023

Natural polymers are increasingly being used in tissue engineering due to their ability mimic the extracellular matrix and act as a scaffold for cell growth, well possible combination with other osteogenic factors, such mesenchymal stem cells (MSCs) derived from dental pulp, an attempt enhance bone regeneration during healing of defect. Therefore, aim this study was analyze repair mandibular defects filled new collagen/chitosan scaffold, seeded or not MSCs pulp. Twenty-eight rats were submitted surgery creation defect right ramus divided into following groups: G1 (control group; clot); G2 (defect pulp cells-DPSCs); G3 scaffold); G4 (collagen/chitosan DPSCs). The analysis microstructure showed homogenous material adequate percentage porosity. Macroscopic radiological examination area after 6 weeks post-surgery revealed absence complete repair, signs infection, which could indicate rejection implants. Histomorphometric that formation occurred centripetal fashion, starting borders progressing towards center all groups. Lower observed when compared groups exhibited greater osteoregenerative capacity, followed by G3. In conclusion, osteoconductivity, no foreign body reaction, malleability ease manipulation, but did obtain promising results association DPSCs.

Language: Английский

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Phthalated cashew gum-based polyelectrolyte complex for oral insulin delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106015 - 106015

Published: Aug. 2, 2024

Language: Английский

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In vitro and in vivo assessment of a non-animal sourced chitosan scaffold loaded with xeno-free umbilical cord mesenchymal stromal cells cultured under macromolecular crowding conditions

Biomaterials and Biosystems, Journal Year: 2024, Volume and Issue: 16, P. 100102 - 100102

Published: Oct. 10, 2024

There is an increasing demand to not only accelerate the development of advanced therapy tissue engineered medicines, but also eliminate xenogeneic materials from their cycle. With these in mind, herein we first assessed influence carrageenan as macromolecular crowding agent enhance and extracellular matrix deposition xeno-free human umbilical cord mesenchymal stromal cell cultures developed characterised a non-animal sourced chitosan scaffold. Following appropriate vitro experimentation, splinted nude mouse wound healing model was used assess closure scar size non-treated control, scaffold, scaffold loaded with cells cultured under conditions groups. Across all three donors, supplementation significantly increased collagen at day 5, 8 11 without affecting morphology, viability, DNA concentration metabolic activity. Through freeze drying, sponge structural mechanical properties for applications. In biological analysis made apparent that neither nor negatively impacted activity proliferation. vivo revealed no significant differences between groups size, raising question about suitability model. any case, this work sets foundations completely medicines.

Language: Английский

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Development of a new biomaterial based on cashew tree gum (Anarcadium occidentale L.) enriched with hydroxyapatite and evaluation of cytotoxicity in adipose-derived stem cell cultures

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124864 - 124864

Published: May 15, 2023

Language: Английский

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Cashew gum as future multipurpose biomacromolecules

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122749 - 122749

Published: Sept. 17, 2024

Language: Английский

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