Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(48), P. 19424 - 19434
Published: Jan. 1, 2024
We report the synthesis and crystal structure of a naphthalimide–methoxyquinoline (NI–HQ) based molecular rotor for visualizing sweat pores without degradation dsDNA present in sweat.
Language: Английский
European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107074 - 107074
Published: March 1, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
This study investigates the use of bimetallic copper-silver nanoclusters (Cu-AgNCs) for fluorescence turn-on sensing leucine, a potential biomarker cancer detection. These exhibit high tunability and specificity, with Fe3+ serving as quencher to facilitate leucine The recovery mechanism is attributed interaction Fe3+, alleviating quenching effect on metal nanoclusters. nanocluster promising platform identification in diagnosis. enhancement upon binding provides measurable signal, confirming feasibility these noninvasive sensors biomarkers. sensor achieves detection limit 0.58 μM demonstrates linear response within range 110-657 μM. approach offers method diagnostics using saliva urine samples. Additionally, method's reproducibility robustness further support its clinical applications, providing cost-effective accessible technique early
Language: Английский
Citations
0
Journal of Computational Chemistry, Journal Year: 2025, Volume and Issue: 46(8)
Published: March 24, 2025
Local nonequilibrium approach has been used for many purposes when dealing with biological systems. Not only unraveling important features of cancer development, a disease that affects the lives people worldwide, but also to understand drug-target interactions in more real scenario, which can help combat this disease. Therefore, aiming contribute new strategies against cancer, present work investigate spectroscopy 2-(2'-hydroxy-4'-aminophenyl)benzothiazole (HABT) interacting PI3K enzyme, widely associated target mentioned illness. The study consisted evaluating Excited State Intramolecular Proton Transfer (ESIPT) performance HABT, spectroscopic terms, enzyme local regime. This scenario could be considered by investigating metastable states HABT system. From this, it was possible observe ESIPT considerably differs comparing solution and protein environments, where 63% have appropriate geometry environment, 97% aqueous environment. Thus, from an entirely theoretical methodology, provides insights modeling systems contributes significantly better comprehension promising probes diagnosis.
Language: Английский
Citations
0
Neurosurgical Review, Journal Year: 2025, Volume and Issue: 48(1)
Published: March 28, 2025
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 9910 - 9951
Published: Jan. 1, 2025
This review presents recent advancements (2019–2024) in BODIPY-based chemosensors for selective detection of mercury ions.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125611 - 125611
Published: April 1, 2025
A novel β-cyclodextrin-aza[5]helicene conjugate as theranostic platform for anticancer agents delivery in cancer cells is here reported. The carrier was synthesized via monotosylation of hydroxyethyl-β-cyclodextrin (HE-β-CD), followed by reaction with the aza[5]helicene, yielding corresponding ammonium tosylate salt. system characterized NMR, FTIR, UV-vis, and PL measurements, demonstrating favorable optical properties. suitability fluorescent to act smart drug therapy investigated choosing gemcitabine (GMC) a model drug. GMC inclusion inside evaluated experimental computational studies which confirmed formation 1:1 complex between β-CD GMC. within cavity led marked enhancement its water solubility. Biological tests conducted on A549 revealed high cell internalization (∼80 %) low cytotoxicity (IC50 = 262.7 µg mL-1) β-CD-aza[5]helicene conjugate. results obtained exploiting host-guest chemistry β-cyclodextrin combined unique photophysical properties aza[5]helicene could pave way new therapies, increasing therapeutic index endowed poor solubility systemic toxicity and, thanks inserted probe, following their release into biological pathways.
Language: Английский
Citations
0
Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112863 - 112863
Published: April 1, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 27, 2025
Abstract A mixed‐ligand‐based novel 3D Cd(II)‐based metal‐organic framework (MOF) is devised from π‐electron‐rich organic struts that shows two‐fold interpenetrated bilayer‐pillar structure. The strong luminescence of the MOF gets remarkably quenched by roxarsone (ROX) organo‐arsenic in water. material further exemplifies one‐of‐a‐kind fluoro‐switchable probe for antibiotics and exhibits massive turn‐off emission tetracycline (TTC), whereas sulfamethazine (SMZ) triggers an unprecedented 120% enhancement. Apart regenerative, fast‐responsive, selective fluoro‐detection all three feed‐additives, particularly significant nanomolar limits detection (LOD) ROX (48.9 n m ), LOD SMZ (33.9 ) ranks lowest, TTC (22.8 stands second lowest among reported sensory MOFs. Besides varying degrees energy transfer contribution TTC, density functional theory calculations manifest changes levels individual organo‐aromatics additionally describe framework–analyte supramolecular interactions. sensor works equally well different wastewater specimens a wide pH range with good recovery percentage. To broaden practical scope material, cheap MOF@paper strip as reconfigurable MOF@chitosan@paper bio‐composite developed successfully employed instantaneous monitoring both at their low concentrations.
Language: Английский
Citations
0
Inorganic Chemistry, Journal Year: 2023, Volume and Issue: 62(41), P. 16734 - 16751
Published: Oct. 2, 2023
A rare example of pyrimidine-based ESIPT-capable compounds, 2-(2-hydroxyphenyl)-4-(1H-pyrazol-1-yl)-6-methylpyrimidine (HLH), was synthesized (ESIPT─excited state intramolecular proton transfer). Its reactions with zinc(II) salts under basic or acidic conditions afforded a dinuclear [Zn2LH2Cl2] complex and an ionic (H2LH)4[ZnCl4]2·3H2O solid. Another solid, (H2LH)Br, obtained from the solution HLH acidified HBr. In both solids, H+ ion protonates same pyrimidinic N atom that accepts O-H···N hydrogen bond in structure free HLH, which breaks this switches off ESIPT these compounds. This series compounds includes neutral molecules (LH)- (H2LH)+ species allowed us to elucidate impact protonation coordination coupled deprotonation on photoluminescence response altering emission mechanism. The compound exhibits yellow as result coexistence two radiative decay channels: (i) T1 → S0 phosphorescence enol form (ii) anti-Kasha S2 fluorescence keto form, if feasible due large S2-S1 energy gap. However, owing efficient nonradiative through energetically favorable conical intersection, quantum yield is low. Protonation ligand results significant blue-shift bands by more than 100 nm boosts efficiency up ca. 20% case (H2LH)4[ZnCl4]2·3H2O. Despite (H2LH)Br have cation structures, their properties differ significantly, whereas shows dual associated S1 phosphorescence, only fluorescence. difference can be external heavy effect leads faster intersystem crossing compound. Finally, huge increase intensity cooling pronounced luminescence thermochromism (violet at 300 K, sky-blue 77 K).
Language: Английский
Citations
9
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216209 - 216209
Published: Sept. 20, 2024
Language: Английский
Citations
3