Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 27, 2024
Language: Английский
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1634 - 1634
Published: Nov. 21, 2023
Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges more traditional methods. RNA-based emerged as a promising avenue, utilizing nanoformulation treatments target range of pathologies. Nanoformulation offers several advantages compared other treatment modalities, including targeted delivery, low toxicity, and bioactivity suitable for drug loading. At present, various types nanoformulations are available, such liposomes, polymeric nanoparticles (NPs), magnetic NPs, nanoshells, solid lipid (SLNs). therapy utilizes intracellular gene with messenger RNA (mRNA) emerging prominently in cancer immunotechnology against infectious diseases. The approval mRNA-based technology opens doors future technological advancements, particularly self-amplifying replicon (repRNA). RepRNA is novel platform therapy, comprising viral unique molecular property enables amplification all encoded genetic information countless times. As result, repRNA-based achieved levels expression. In this context, primary objective study furnish comprehensive review repRNA its applications treatments, specific focus on encapsulated nanoparticles. overarching goal provide an extensive overview use conjunction across therapies.
Language: Английский
Citations
6
Journal of Advanced Pharmaceutical Technology amp Research, Journal Year: 2023, Volume and Issue: 14(3), P. 176 - 184
Published: July 1, 2023
A series of eight novels' 1,3-diazetidin-2-ones have been proposed to assess their potential activities. They are intended examine antiproliferative effects through inhibition epidermal growth factor receptor (EGFR) expression. These compounds strongly interact with the EGFR protein, responsible for activity. As part a present study, these were docked crystal structure (Protein Data Bank code: 1 M17) determine binding affinity at active site. Based on computer predictions, two demonstrated high scores 80.80 and 85.89. After analyzing ADME properties, found significant binding. Consequently, abilities gefitinib, erlotinib, imatinib, sorafenib selected comparison as controls. Computational methods performed predict critical disposition 1,3-diazetidin-2-one derivatives EGFR. Moreover, docking technique employing Genetic Optimization Ligand Docking program was conducted. Compounds 2 7 demonstrate peace-wise scoring function (PLP) fitness 85.89 80.80, respectively. fulfilled Lipinski's rule, topological descriptors, fingerprints drug-like molecular keys. can be used lead develop novel agents. The outcome applying this study is new analogs designed evaluated activity higher potency profile within sites
Language: Английский
Citations
5
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1129 - 1129
Published: Aug. 27, 2024
In 2022, 2.5 million cases of lung cancer were diagnosed, resulting in 1.8 deaths. These statistics have motivated us to introduce a new natural product which is feasible therapies. This comprehensive study was performed the effects chia seed extracts (70% ethanol and petroleum ether) on vitro vivo models. The invitro cytotoxicity activity studied cell lines (A549 cells). After 48 h, alcohol ether showed more inhibitory influence (IC50, 16.08, 14.8 µg/mL, respectively) A549 cells compared Dox 13.6 µg/mL). vivo, administration (500 mg/kg/day, orally for 20 weeks) recovered 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced cancer, as significant reduction biomarkers, including relative weight (20.0 13.33%), ICAM(31.73 15.66%), c-MYC (80 96%) MMP9(60 69%) expression genes, improvement these changes observed by histopathological examinations tissues control. Chia seeds fought via suppression proliferation, angiogenesis, inflammation, activation apoptosis. activities may be attributed chemical composition chia, identified LC-Mass, such caffeic acid, vanillic kaempferol-3-O-glucuronide, taxifolin. Finally, we can conclude that an anti-lung effect with good safety margin.
Language: Английский
Citations
1
Molecular Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Lung cancer is the leading cause of death globally, with non‐small cell lung accounting for majority (85%) cases. Standard treatments including chemotherapy and radiotherapy present multiple adverse effects. Medicinal plants, used centuries, are traditionally processed by methods such as boiling oral ingestion, However, water solubility, absorption, hepatic metabolism reduce phytoceutical bioavailability. More recently, isolated molecular compounds from these plants can be extracted phytoceuticals administered either individually or an adjunct standard therapy. Phytoceuticals have been shown to alleviate symptoms, may dosage and, in some cases, enhance pharmaceutical mechanisms. Research has identified many phytoceuticals' actions on cancer‐associated pathways, oncogenesis, tumour microenvironment, proliferation, metastasis, apoptosis. The development novel nanoparticle delivery systems solid lipid nanoparticles, liquid crystalline liposomes enhanced bioavailability targeted pharmaceuticals phytoceuticals. This review explores biological pathways associated cancer, a diverse range phytoceuticals, they act upon, pros cons several systems.
Language: Английский
Citations
1
Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122333 - 122333
Published: Dec. 6, 2023
Language: Английский
Citations
2
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 27, 2024
Language: Английский
Citations
0