Exosome-based platforms for treatment of multiple sclerosis DOI Creative Commons
Aidin Mohammadi Zonouz, Mahboobeh Ghasemzadeh Rahbardar, Mona Alibolandi

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 222, P. 111256 - 111256

Published: Feb. 12, 2025

Multiple sclerosis (MS) is a chronic autoimmune illness characterized by inflammation and demyelination of the central nervous system (CNS). The effective delivery therapeutic agents to CNS continues be an important barrier in MS treatment due blood-brain limited access affected areas. Exosome-based drug systems have become attractive option for targeted therapy MS. Exosomes, small extracellular vesicles derived from various cell types, possess unique biological properties that make them ideal nanocarriers delivering cargo specific populations CNS. In this study, we supply comprehensive overview current advances future perspectives exosome-based We discuss biogenesis exosomes, strategies loading, engineering approaches enhance their targeting capabilities, potential clinical applications exosome-mediated therapy. Additionally, explore preclinical studies animal models demonstrate effectiveness ameliorating pathology. By highlighting challenges opportunities utilizing exosomes as vehicles, review aims contribute growing body knowledge field nanomedicine Considering accessibility, specificity, therapies while minimizing off-target effects might change scenario

Language: Английский

Exosome-Based Drug Delivery: Translation from Bench to Clinic DOI Creative Commons
Hee Byung Koh, Hyo Jeong Kim, Shin‐Wook Kang

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2042 - 2042

Published: July 29, 2023

Exosome-based drug delivery is emerging as a promising field with the potential to revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles released by various cell types, have attracted significant attention due their unique properties and natural ability transport bioactive molecules. These nano-sized vesicles, ranging in size from 30 150 nm, can effectively variety of cargoes, including proteins, nucleic acids, lipids. Compared traditional systems, exosomes exhibit biocompatibility, low immunogenicity, reduced toxicity. In addition, be designed tailored improve targeting efficiency, cargo loading capacity, stability, paving way for personalized medicine precision therapy. However, despite exosome-based delivery, its clinical application remains challenging limitations exosome isolation purification, efficiency insufficient targeted rapid elimination circulation. This comprehensive review focuses on transition bench clinic, highlighting key aspects, such structure biogenesis, methods, surface engineering techniques, applications. It also discusses challenges prospects this field.

Language: Английский

Citations

78
Exosome as drug delivery system: Current advancements DOI Creative Commons
Vriti Sharma, Chitrangada Das Mukhopadhyay

Extracellular Vesicle, Journal Year: 2023, Volume and Issue: 3, P. 100032 - 100032

Published: Dec. 9, 2023

Exosomes are nanovesicles released from cells due to pathophysiological events. These nanoparticles resistant metabolic destruction and can transcend the blood-brain barrier. Exosome therapy could be employed as precision medicine by targeting underlying etiology. This article briefly elucidates basic physiology of exosomes, their types, characteristics, cargo that for drug administration. It then delves into therapeutic applications, such oncology, neurological disorders, regenerative medicine. Exosome-based delivery using small molecules, nucleic acids, proteins is also demonstrated. Finally, global organizations successfully creating testing medicinal biomaterials highlighted.

Language: Английский

Citations

50
Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade DOI Creative Commons
Saeid Moghassemi, Arezoo Dadashzadeh, Maria João Sousa

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 126 - 156

Published: March 2, 2024

Small extracellular vesicles (sEVs) are known to be secreted by a vast majority of cells. These sEVs, specifically exosomes, induce specific cell-to-cell interactions and can activate signaling pathways in recipient cells through fusion or interaction. nanovesicles possess several desirable properties, making them ideal for regenerative medicine nanomedicine applications. properties include exceptional stability, biocompatibility, wide biodistribution, minimal immunogenicity. However, the practical utilization particularly clinical settings at large scale, is hindered expensive procedures required their isolation, limited circulation lifetime, suboptimal targeting capacity. Despite these challenges, sEVs have demonstrated remarkable ability accommodate various cargoes found extensive applications biomedical sciences. To overcome limitations broaden potential applications, researchers should strive deepen understanding current loading, characterization techniques. Additionally, acquiring fundamental knowledge about origins employing state-of-the-art methodologies expand research scope. This review provides comprehensive overview exosome-based strategies diverse domains, encompassing cancer therapy, immunotherapy, biomarker Furthermore, we emphasize immense exosomes medicine.

Language: Английский

Citations

31
Engineered brain‐targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma DOI Creative Commons
Jun Yang, Yong Li,

Shaoping Jiang

et al.

Exploration, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract The immunosuppressive microenvironment of glioblastoma multiforme (GBM) severely impacts the response to various treatments, including systemic chemotherapy. Targeted reprogramming GBM using RNA interference (RNAi) is largely restricted by poor brain delivery efficiency and targeting specificity. Herein, an acid‐cleavable transferrin (Tf) decorated engineering exosome‐based brain‐targeting system (ACTE) was proposed efficiently deliver small towards transform growth factor‐β (siTGF‐β) doxorubicin (DOX) site for combination chemo‐immunotherapy. siTGF‐β DOX co‐loaded ACTE, termed as DOX&siTGF‐β@ACTE (Ds@ACTE), designed specifically recognize Tf receptor (TfR) on blood‐brain barrier (BBB). Subsequently, Ds@ACTE undergoes acid‐responsive detachment within lysosome capillary endothelial cells, leading separation DOX&siTGF‐β@Exo (Ds@Exo) from Tf‐TfR complex enhanced BBB transcytosis. After crossing BBB, separated Ds@Exo can further target cells via homing effect. In vivo studies validated that significantly downregulated TGF‐β expression reprogram microenvironment, thereby reinforce chemotherapeutic effect DOX‐induced anti‐tumor immune response. effectiveness this strategy not only provide thinking designing a more intelligent based engineered exosomes but also explore effective treatment regimen GBM.

Language: Английский

Citations

20
Microglia-derived exosomal ciRS-7 mediates IL-17A effect of promoting neurodegeneration via miR-7 and SNCA targets in an experimental Parkinson’s disease DOI

Fen-Fen Xu,

Zhan Liu, Xiaoxia Fang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114089 - 114089

Published: Jan. 19, 2025

Language: Английский

Citations

2
Research Advances of Engineered Exosomes as Drug Delivery Carrier DOI Creative Commons
Lianghui Huang,

Enguang Wu,

Jiawei Liao

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(46), P. 43374 - 43387

Published: Nov. 9, 2023

Exosomes are nanoscale vesicles secreted by living cells that have similar membrane composition to parental and carry a variety of proteins, lipids, nucleic acids. Therefore, exosomes certain biological activities play an important role in intercellular communication. On the basis its potential as carrier for drug delivery systems, been engineered compensate shortage natural through various engineering strategies improving efficiency, enhancing targeting tissues organs, extending circulating half-life exosomes. This review focuses on loading drugs different strategies, discussions exosome surface modification summarizes advantages disadvantages strategies. In addition, this provides overview recent applications number refractory relapsable diseases. has provide reference further research development

Language: Английский

Citations

35
Exosomal RNAs and EZH2: unraveling the molecular dialogue driving tumor progression DOI
Ahmed Hussein Zwamel, Adnan Ahmad, Farag M. A. Altalbawy

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 12, 2025

Language: Английский

Citations

1
Progress and Challenges in the Diagnosis and Treatment of Brain Cancer Using Nanotechnology DOI
Yogita Ale, Nidhi Nainwal

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(10), P. 4893 - 4921

Published: Aug. 30, 2023

Primary brain cancer or is the overgrowth of abnormal malignant cells in its nearby tissues that form unwanted masses called tumors. People with tumors suffer a lot, and expected life span patients after diagnosis often only around 14 months, even most vigorous therapies. The blood–brain barrier (BBB) main body restricts entry potential chemotherapeutic agents into brain. chances treatment failure low therapeutic effects are some significant drawbacks conventional methods. However, recent advancements nanotechnology have generated hope treatment. Nanotechnology has shown vital role starting from early detection, diagnosis, cancer. These tiny nanomaterials great to deliver drugs across BBB. Beyond just drug delivery, can be simulated generate fluorescence detect current Review discusses detail challenges application overcome those challenges. success surgical removal requires proper imaging. Nanomaterials provide imaging benefits for discussed by reviewing past studies.

Language: Английский

Citations

18
Exosomes Interactions with the Blood–Brain Barrier: Implications for Cerebral Disorders and Therapeutics DOI Open Access

Zaynab Osaid,

Mohamed Haider, Rifat Hamoudi

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15635 - 15635

Published: Oct. 26, 2023

The Blood-Brain Barrier (BBB) is a selective structural and functional barrier between the circulatory system cerebral environment, playing an essential role in maintaining homeostasis by limiting passage of harmful molecules. Exosomes, nanovesicles secreted virtually all cell types into body fluids, have emerged as major mediator intercellular communication. Notably, these vesicles can cross BBB regulate its physiological functions. However, precise molecular mechanisms which exosomes remain unclear. Recent research studies focused on effect BBB, particularly context their involvement onset progression various disorders, including solid metastatic brain tumors, stroke, neurodegenerative, neuroinflammatory diseases. This review focuses discussing summarizing current knowledge about pathological modulation BBB. A better understanding this regulation will improve our pathogenesis diseases enable design effective treatment strategies.

Language: Английский

Citations

18
Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design DOI Creative Commons

Daed El Safadi,

Alexandre Mokhtari,

Morgane Krejbich

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(3), P. 280 - 280

Published: March 7, 2024

Exosomes are small subtypes of extracellular vesicles (EVs) naturally released by different types cells into their environment. Their physiological roles appear to be multiple, yet many aspects biological activities remain understood. These can transport and deliver a variety cargoes may serve as unconventional secretory vesicles. Thus, they play crucial role important vectors for intercellular communication the maintenance homeostasis. Exosome production content vary under several stresses or modifications in cell microenvironment, influencing cellular responses stimulating immunity. During infectious processes, exosomes described double-edged swords, displaying both beneficial detrimental effects. Owing tractability, analysis EVs from multiple biofluids has become booming tool monitoring various pathologies, cancerous origins. In this review, we present an overview exosome features discuss particular ambiguous functions contexts. We then focus on properties diagnostic therapeutic tools. regard, explore capacity vectorize immunogenic viral antigens function mounting adaptive immune responses. As provide interesting platforms antigen presentation, further review available data engineering, which enables peptides interest exposed at surface. light all these data, emerging promising avenues vaccine strategies.

Language: Английский

Citations

8