Depression, an unmet health need in Africa: Understanding the promise of ketamine

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28610 - e28610

Published: March 28, 2024

In Africa, there is currently a paucity of data on the epidemiology depression, its treatment and management. The prevalence depression severely underestimated, with unique circumstances societal risk factors associated public awareness. Treating managing confounded by an inaccessibility to efficient low-cost treatments for patients depression. aetiology multifactorial, various theories implicating multiple neuronal networks. Despite this, one-dimensional focussing outdated mainly targeting dysfunctional neurotransmitter pathways. Hence, it not surprising that significant increase in suffering from resistant (TRD), large portion deriving little clinical benefit these traditional anti-depressant therapies. This highlights need more effective strategies especially applicable resource limited environments such as where investment healthcare resources towards mental health disorders. potential using ketamine has received considerable attention past two decades, FDA approving esketamine management TRD 2019. widespread significantly increased ketamine's appeal novel antidepressant. Consequently, many infusion clinics have been established Africa. However, regulation or guidance infusions. Furthermore, while expensive hence inaccessible African population, racemic cheaper demonstrated potential. understanding neurological mechanisms action treating diverse population. Therefore, this review aims provide context therapeutic highlighting aspects molecular mechanism action.

Language: Английский

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Optimizing esketamine administration for postoperative depression: a comprehensive study on laparoscopic bariatric surgery patients

Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Previous studies have reported conflicting findings regarding the efficacy of esketamine in managing postoperative depression. While positive effects subanesthetic doses been observed treatment-resistant depression, response to this medication patients experiencing depression following surgery has not consistent. Building upon known impact anesthesia on brain function, we formulated a hypothesis suggesting that timing administration relation may significantly affect its The aim study was investigate effect administered at different time points before and after anesthesia.

Language: Английский

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Acute stress induces different changes on the expression of CB1 receptors in the hippocampus of two lines of male rats differing in their response to stressors

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: unknown, P. 173901 - 173901

Published: Oct. 1, 2024

Language: Английский

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Microglia stimulation produces antidepressant-like effects in a mouse depression model induced by adolescent chronic unpredictable stress

Physiology & Behavior, Journal Year: 2024, Volume and Issue: 291, P. 114782 - 114782

Published: Dec. 12, 2024

Language: Английский

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