The Role of Biologicals Azotohelp®, Liposam®, and Organic-Balance® as Mitigators of Abiotic Stress in Maize Plants DOI
V. Bolokhovskyi, Olga Nagorna, Valentyna Bolokhovska

et al.

Advances in environmental engineering and green technologies book series, Journal Year: 2024, Volume and Issue: unknown, P. 493 - 524

Published: Sept. 27, 2024

In this study the expression of drought-resistance marker genes ZmNHL1, ZmVPP1, ZmNAC111: antiradical activity, relative water content and biochemical chromatographic profiling phenolic compound complex in leaves maize plants treated by biopreparations under drought stress, was investigated. Drought stress significantly affected stress-responsive action (in 4-7 folds). The variant with «Organic-Balance®» 0.5 l/ha + «Azotohelp®» 0.3 «Liposam®» 0.25 were characterized high total compounds, highest activity (88.2%), most active glycosylation processes flavonoids (up to 13%), (97.3%) compared control. PCA PLS-DA showed that alterations secondary metabolites, induced biopreparations, serve as an initial mechanism for activation plant's antioxidant system, leading a more robust defence system post-stress signals.

Language: Английский

Biological Characterization of One Oxadiazole Derivative (5(4‐Hydroxyphenyl)‐2‐(N‐Phenyl Amino)‐1,3,4‐Oxadiazole): In Vitro, In Silico, and Network Pharmacological Approaches DOI Open Access
Tuğçe Duran,

Irem Balikci,

Busra Buyukkosucu

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(1)

Published: Jan. 1, 2025

ABSTRACT Oxadiazole compounds are of great interest because they have a range biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted demonstrate the antioxidant, enzyme inhibitory, and effects 5(4‐hydroxyphenyl)‐2‐(N‐phenylamino)‐1,3,4‐oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging reducing power tests. Enzyme inhibitory studied by cholinesterases, tyrosinase, amylase, glucosidase. The effect was tested on pancreatic cancer cell lines (PANC‐1, CRL‐169) HEK293 lines. compound showed significant antioxidant activity (particularly in CUPRAC (cupric acid‐reducing capacity) assay) properties glucosidase inhibition). In test, strong with apoptotic signaling pathways. These results confirmed molecular modeling bioinformatics tools. Thus, our findings can provide novel versatile for development multidirectional drugs pharmaceutical industry.

Language: Английский

Citations

0
Synthesis, pharmacological evaluation, and molecular docking studies of some 1,3,4-oxadiazolyl-5-yl thiones bearing halo-nitrophenyl hydrazides derivatives as antioxidant and antimicrobial agents DOI
Fatima Belkhadem, Fawzia Taieb Brahimi,

Zohra Douaa Benyahlou

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1329, P. 141389 - 141389

Published: Jan. 10, 2025

Language: Английский

Citations

0
Design, Synthesis, and In Vitro and In Silico Biological Exploration of Novel Pyridine‐Embedded 1,3,4‐Oxadiazole Hybrids as Potential Antimicrobial Agents DOI Creative Commons

K. N. Shivakumara,

S. M. Basavarajaiah,

Nagesh Gunavanthrao Yernale

et al.

Journal of Chemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Antibiotic resistance represents a significant public health challenge in the current century. The β‐lactam antibiotics, together with carbapenems, are inactivated by zinc‐dependent bacterial enzymes called metallo‐β‐lactamases (MBLs). Presently there no clinically permitted MBL inhibitors, and to produce such drugs, it is indispensable comprehend their inhibitory action. We investigated an efficient synthesis of pyridine‐embedded 1,3,4‐oxadiazole hybrids (3a-c) antimicrobial activity against different microbial strains. compounds were characterized spectral techniques (viz., IR, NMR, mass). vitro antibacterial antifungal was also performed; displayed excellent activity. silico docking studies evaluated proteins New Delhi Metallo-Beta-lactamase-1 (NDM‐1) Mycobacterium tuberculosis enoyl reductase (INHA). All demonstrated binding affinity for docked proteins. Additionally, molecular dynamics disclosed (4a-c) .

Language: Английский

Citations

0
Drug designing and synthesis of novel diphenyl 1,3,4 oxadiazoles: Multi-targeted therapeutics for the treatment of malassezia-induced dandruff DOI Creative Commons

S Varma,

Shivam Varma,

Sumit Waragade

et al.

Letters in Drug Design & Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100001 - 100001

Published: April 1, 2025

Language: Английский

Citations

0
Novel antioxidants based on polymerized 2,2,4-trimethyl-1,2-dihydroquinoline for styrene-butadiene rubber composites DOI
T. A. Zidan, A. A. Yehia

Journal of Polymer Research, Journal Year: 2024, Volume and Issue: 31(6)

Published: June 1, 2024

Language: Английский

Citations

3
Discovery of Novel Isatin Encompassing Oxadiazoles as Potential Inhibitors against New Delhi Metallo-β-lactamase-1: Synthesis, Spectral Analysis, Antimicrobial, and Molecular Modeling Studies DOI

B. Sridhar,

Nagesh Gunavanthrao Yernale,

Prashantha Karunakar

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 50(4), P. 1376 - 1389

Published: Aug. 1, 2024

Language: Английский

Citations

3
Substrate‐based synthetic strategies and biological activities of 1,3,4‐oxadiazole: A review DOI
Upasna Sharma, Rajnish Kumar, Avijit Mazumder

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(6)

Published: June 1, 2024

Abstract The five‐membered 1,3,4‐oxadiazole heterocyclic ring has received considerable attention because of its unique bio‐isosteric properties and an unusually wide spectrum biological activities. After a century since was discovered, uncommon potential attracted medicinal chemist's attention, leading to the discovery few presently accessible drugs containing units, large number patents have been granted on research related 1,3,4‐oxadiazole. It is worth noting that interest in 1,3,4‐oxadiazoles' applications doubled last years. Herein, this review presents comprehensive overview recent achievements synthesis 1,3,4‐oxadiazole‐based compounds highlights major advances their 10 years, as well brief remarks prospects for further development. We hope researchers across scientific streams will benefit from presented articles designing work 1,3,4‐oxadiazoles.

Language: Английский

Citations

2
Benzohydrazide as a good precursor for the synthesis of novel bioactive and anti-oxidant 2-phenyl-1,3,4-oxadiazol-aminoacid derivatives: Structural determination, biological and anti-oxidant activity DOI Creative Commons

Khaled Briki,

Talal Lahreche,

Mouna Souad Abbassi

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(6), P. 105767 - 105767

Published: March 30, 2024

The synthesis and biological assessment of 2,5-disubstituted-1,3,4-oxadiazole derivatives from benzo hydrazide amino acids as novel potential antioxidant antibacterial agents have been reported. structures the new compounds were characterized by physicochemical properties spectral methods. synthesized screened for their in vitro activity against three Gram-positive bacterial strains, namely Staphylococcus aureus ATCC 25923, Bacillus cereus 14579, Listeria innocua 33090, two Gram-negative Pseudomonas aeruginosa 27853, Escherichia coli 25922, antifungal Candida albicans 10231 comparison with Amoxicillin, Tetracycline, Gentamicin Oxacillin standards. Most excellent efficacy, some them, such 5i, 5g, 5d, 5c, 5j can inhibit better or very close to that Gentamicin, used Compounds 5b 5i provided good results L. inhibition values IZ = 14 mm 22 mm, respectively, while rest antibiotics unable it. 5g showed C. between 31 34 mm. These than all standards used. MIC value (25 µg/ml) 5(c-e), 5(i-j) B. represent best tested compounds. All target also radical scavenging activities DPPH, FRAP, TAC assays found be agents. According results, it was observed most a concentration 250 µg/ml an agent (76 % < RSA 95.5 %) which gave percentage ascorbic acid BHT.

Language: Английский

Citations

1
Design, Synthesis, Characterization, Invitro Anticancer Evaluation, Computational studies, and in silico ADME assessment of New N-(5-o-tolyl-1,3,4-oxadiazol-2-yl) alkanamides DOI
Kadeer Md,

Ravi Kumar Parangi,

D. Ramesh

et al.

Chemical Data Collections, Journal Year: 2024, Volume and Issue: unknown, P. 101167 - 101167

Published: Oct. 1, 2024

Language: Английский

Citations

1
Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies DOI Creative Commons
Obaid Afzal, Amena Ali, Abuzer Ali

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6086 - 6086

Published: Aug. 16, 2023

We report herein the synthesis, docking studies and biological evaluation of a series new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues (6a-h). The compounds were designed based on oxadiazole-linked aryl core tubulin inhibitors IMC-038525 IMC-094332, prepared in five steps further characterized via spectral analyses. anticancer activity was assessed against several cancer cell lines belonging to nine different panels as per National Cancer Institute (NCI US) protocol. 4-Chloro-2-((5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)amino)phenol (6h) demonstrated significant SNB-19 (PGI = 65.12), NCI-H460 55.61), SNB-75 54.68) at 10 µM. subjected molecular active site tubulin-combretastatin A4 complex (PDB ID: 5LYJ); they displayed efficient binding ligand 4h (with score -8.030 kcal/mol) lay within hydrophobic cavity surrounded by important residues Leu252, Ala250, Leu248, Leu242, Cys241, Val238, Ile318, Ala317, Ala316. Furthermore, antibacterial some found be promising. 4-Chloro-2-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)amino)phenol (6c) most promising both Gram-negative well Gram-positive bacteria with MICs 8 µg/mL zone inhibition ranging from 17.0 ± 0.40 0.15 mm 200 µg/mL; however, standard drug ciprofloxacin exhibited MIC values 4 µg/mL.

Language: Английский

Citations

2