Synthesis, characterization, antimicrobial and antioxidant activity of 2- (2′-hydroxyphenyl) -1,3,4-oxadiazolyl-5-amino acid derivatives

Journal of Saudi Chemical Society, Journal Year: 2024, Volume and Issue: 28(3), P. 101866 - 101866

Published: April 30, 2024

The synthesis and biological assessment of 2,5-disubstituted-1,3,4-oxadiazoles derivatives from amino acids as new potential antibacterial antioxidant agents have been reported. structures the synthesized compounds were characterized based on physicochemical spectral data UV–Visible, IR, 1HNMR, 13CNMR. All target screened for their in vitro activity against three Gram-positive bacterial strains, namely Staphylococcus aureus ATCC 25923, Bacillus cereus 14579, Listeria innocua 33090, two Gram-negative Pseudomonas aeruginosa 27853, Escherichia coli 25922, antifungal Candida albicans 10231 comparison with Amoxicillin, Tetracycline, Gentamicin Oxacillin. only compound 1-{(4S)-4-amino-4-[5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]butyl}guanidine 5e amine radical that showed excellent results all bacteria, particularly L. (IZ = 12 mm), has 32 mm). 2-[5-(1-amino-3-methylbutyl)-1,3,4-oxadiazol-2-yl]phenol 5b 2-[5-(pyrrolidin-2-yl)-1,3,4-oxadiazol-2-yl]phenol 5j activities 27 IZ 28 mm, respectively) B. P. aeruginosa. Compounds 2-{5-[(1R)-1-amino-2-sulfanylethyl]-1,3,4-oxadiazol-2-yl}phenol 5c, 2-{5-[(1S)-1-amino-3-(methylsulfanyl)propyl]-1,3,4-oxadiazol-2-yl}phenol 5d sulfur radical, 3--[5-(2-3-amino hydroxyphenyl)-1,3,4-oxadiazol-2-yl]propanamide 5g amide 4-amino-4-[5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]butanoic acid 5k gave good cereus, where 19 mm < 23 mm. We also found greatest 33 mm) C. albicans, followed by 30 scavenging DPPH, FRAP, TAC assays to be agents. According IC50 values, demonstrated activity, especially 2-{5-[1-amino-2-(1H-imidazol-4-yl)ethyl]-1,3,4-oxadiazol-2-yl}phenol 5i FRAP methyl 2-hydroxybenzoate 2, 2-{5-[1-amino-2-(1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-yl}phenol 5h imidazol group 2-[5-(1,5-diaminopentyl)-1,3,4-oxadiazol-2-yl]phenol 5f TAC. these better than AA BHT.

Language: Английский

Synthesis, Structural, DFT studies, Biological Effectiveness, and Molecular Docking Aspects of Multitarget Novel N-(4-Phenylthiazol-2-yl)hydrazine carboxamide Hybrids as COX inhibitors, Anti-TB, and Anti-oxidant activity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 140081 - 140081

Published: Sept. 24, 2024

Language: Английский

The Role of Biologicals Azotohelp®, Liposam®, and Organic-Balance® as Mitigators of Abiotic Stress in Maize Plants

Advances in environmental engineering and green technologies book series, Journal Year: 2024, Volume and Issue: unknown, P. 493 - 524

Published: Sept. 27, 2024

In this study the expression of drought-resistance marker genes ZmNHL1, ZmVPP1, ZmNAC111: antiradical activity, relative water content and biochemical chromatographic profiling phenolic compound complex in leaves maize plants treated by biopreparations under drought stress, was investigated. Drought stress significantly affected stress-responsive action (in 4-7 folds). The variant with «Organic-Balance®» 0.5 l/ha + «Azotohelp®» 0.3 «Liposam®» 0.25 were characterized high total compounds, highest activity (88.2%), most active glycosylation processes flavonoids (up to 13%), (97.3%) compared control. PCA PLS-DA showed that alterations secondary metabolites, induced biopreparations, serve as an initial mechanism for activation plant's antioxidant system, leading a more robust defence system post-stress signals.

Language: Английский