Harnessing phytoconstituents in ethosomes: A new frontier in skin disorder management

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125273 - 125273

Published: Jan. 1, 2025

Language: Английский

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Cannabidiol - a friend or a foe?

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107036 - 107036

Published: Feb. 1, 2025

Cannabidiol (CBD), one of the main actives from Cannabis sativa has been perpetually explored lately for its therapeutic effects. Its attributes, such as anti-inflammatory and antioxidant effects, snowball into pain management, epilepsy seizure alleviation, anxiety relief, well numerous other implications through entire metabolism. However, conventional administration routes challenge potential, with reported poor water solubility, hepatic degradation, gastric instability erratic bioavailability observed in oral administration. As a result, transdermal delivery systems have emerged promising alternative to or inhaled routes, offering improved targeted The medical use CBD throughout Europe, UK, USA Australia is extensive usually represented by pharmaceutical preparations recommended after treatment routs fail. non-medical limited each country's own legislation, wider range products being available, but irregular regulatory landscape coupled growing market cannabinoid-infused products, emphasizes need standardized formulations further clinical research. present work critically examines cannabidiol, explores skin's potential route strategies involved using it systemic targeting. We highlighted key challenges provided insights CBD`s variable based on different methods, thus compiling literature-based absorption, distribution, metabolism, excretion (ADME) study. also explore role endocannabinoid system, function various conditions, effects associated CBD, particularly light varying legislation across countries. While breadth benefits compelling, essential emphasize ongoing nature research individual responses can vary significantly.

Language: Английский

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Carbon-Based Nanoparticles for Neural Regeneration

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 263 - 282

Published: Jan. 1, 2025

Language: Английский

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Evaluation of Biophysical Parameters of the Skin of Patients With Atopic Dermatitis After Application of an Ointment Containing 30% Cannabidiol and 5% Cannabigerol

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 649 - 662

Published: March 1, 2025

A growing number of publications are devoted to topical cannabinoid therapies in present-day cosmetology, as they appear be safe and effective treatment modalities aimed at improving the comfort quality life patients with atopic dermatitis (AD). thorough patient interview, physical examination, clinical picture, aetiopathogenesis AD allow for a correct diagnosis enable choice least invasive pharmacological treatment. In our medical experiment, we found correlation between findings studies by other authors validation hypothesis that therapy is prevention management flares. analysis obtained results provided insights into extent which applied ointment influenced improvement skin's biophysical parameters (hydration, lipid content, transepidermal water loss, erythema). This experimental study was conducted from May July 2022 included group nine (five men four women) aged 20- 67-years-old were diagnosed AD. The involved transdermal delivery an compounded cholesterol ointment, 30% cannabidiol (CBD), 5% cannabigerol (CBG), hemp seed oil, assessment skin parameters, including corneometry (skin hydration), TEWL, sebumetry, pH (acidity). preliminary pilot points potential employing ointments creams containing CBD CBG alternatives conventional auxiliary during both flare-ups remission. achieved improved hydration, sebum level, TEWL well reduced erythema studied areas (forearms). Our demonstrate reducing itching AD, leading symptom remission some cases.

Language: Английский

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Beyond Cannabidiol: The Contribution of Cannabis sativa Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 647 - 647

Published: April 28, 2025

Background: Cannabis sativa L. (C. sativa) has a long history of medicinal use. Its inflorescences contain bioactive compounds like non-psychotropic cannabidiol (CBD), which is well known for its anti-inflammatory potential in skin conditions such as psoriasis, and psychotropic Δ-9-tetrahydrocannabinol (THC). Keratinocytes, the main cells epidermis, are crucial regulating inflammation by producing mediators IL-8 when stimulated agents TNFα. Methods: This study explores effects standardized C. extract (CSE) with 5% CBD less than 0.2% THC human keratinocytes challenged The aim this to analyze specific contributions constituents CSE inflammatory responses fractionating examining individual components. Results: MTT assays showed that was non-toxic HaCaT up 50 μg/mL. inhibited NF-κB activity reduced secretion concentration-dependent manner, mean IC50 values 28.94 ± 10.40 μg/mL 20.06 2.78 (mean SEM), respectively. Fractionation into four subfractions revealed more lipophilic fractions (A B) were most effective inhibiting NF-κB, indicating cannabinoids cannflavins key contributors. Pure one active reducing NF-κB-driven transcription (together cannabigerol), due abundance CSE, it primarily responsible activity. Conclusions: highlights CBD’s significant role underscores need consider synergistic interactions several molecules within extracts maximum efficacy. Standardized essential reproducible results variability responses.

Language: Английский

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Applications of supercritical CO ₂ of legal cannabinoids in skin care products and cosmetics

Journal of Liquid Chromatography &amp Related Technologies, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 2, 2025

Language: Английский

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The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1827 - 1827

Published: Oct. 4, 2023

Cannabis sativa, a versatile plant with numerous varieties, holds promising potential for wide range of biological activity. As raw materials research, we chose leaves and inflorescences hemp varieties such as Białobrzeskie, Henola, Tygra, which are cultivated mainly their fibers or seeds. The choice extraction is key step in obtaining the selected compositions active compounds from material. Bearing mind lipophilic nature cannabinoids, performed supercritical carbon dioxide (scCO2) at 50 °C under 2000 (a) 6000 PSI (b). cannabinoid contents were determined use HPLC-DAD method. antioxidant capabilities assessed through series procedures, including DPPH, ABTS, CUPRAC, FRAP methods. capacity to inhibit enzymes that play role progression neurodegenerative diseases, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase was also studied. dominant cannabinoids extracts cannabidiol (CBD) cannabidiolic acid (CBDA). highest concentration eight detected Tygra extract most notable properties provided by Nonetheless, it Henola (b) demonstrated efficient inhibition AChE BChE, inhibited significantly Białobrzeskie Multidimensional comparative analysis enrolled all assays revealed showed substantial neuroprotective potential.

Language: Английский

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Breast Cancer Exposomics

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 402 - 402

Published: March 18, 2024

We are exposed to a mixture of environmental man-made and natural xenobiotics. experience wide spectrum exposure in our lifetime, including the effects xenobiotics on gametogenesis gametes that undergo fertilization as starting point individual development and, moreover, utero exposure, which can itself cause first somatic or germline mutation necessary for breast cancer (BC) initiation. Most metabolized or/and bioaccumulate biomagnify tissues cells, tissues, so xenobiotic metabolism plays an important role BC initiation progression. Many considerations necessitate more valuable explanation regarding molecular mechanisms action act genotoxic epigenetic carcinogens. Thus, exposomics exposome concept based diversity range exposures physical factors, synthetic chemicals, dietary components, psychosocial stressors, well their associated biologic processes pathways. Existing evidence risk (BCR) suggests food-borne chemical carcinogens, air pollution, ionizing radiation, socioeconomic status closely related carcinogenesis. The aim this review was depict dynamics kinetics several involved development, emphasizing new omics fields exposomics, such toxicogenomics, epigenomics interactomics, metagenomics, nutrigenomics, nutriproteomics, nutrimiRomics. mainly focused food nutrition, endocrine-disrupting chemicals (EDCs), development. Overall, cell tissue accumulation biotransformation lead modifications composition morphology, DNA damage genomic instability, epimutations, RNA-mediated extracellular vesicle effects, aberrant blood methylation, stimulation epithelial-mesenchymal transition (EMT), disruption cell-cell junctions, reorganization actin cytoskeleton, metabolic reprogramming, overexpression mesenchymal genes. Moreover, into cells impacts almost all known carcinogenic Conversely, food, there many bioactive compounds with anti-cancer potential, exerting pro-apoptotic roles, inhibiting cycle progression proliferation, migration, invasion, damage, stress conditions. conclude has high potential demonstrate how acts double-edged sword, promoting suppressing tumorigenesis BC.

Language: Английский

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Comprehensive Insight into Cutaneous Application of Hemp

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 748 - 748

Published: May 31, 2024

Known for its natural bio-compounds and therapeutic properties, hemp is being utilized in the development of skin products. These products offer a wide range applications benefits fields bio-compounds, pharmaceutical technology, topical delivery systems, cosmeceuticals. This manuscript deals with actives, such as cannabinoids, terpenes, flavonoids, their diverse biological properties relative to application, including anti-inflammatory, antimicrobial, antioxidant effects. Also, paper reviews strategies overcome poor penetration well integration actives cosmeceuticals that provide sustainable alternatives traditional skincare offering benefits, anti-aging, moisturizing, soothing properties. The review aims comprehensive understanding manufacturing processes containing actives. By delving into science behind hemp-based products, provides valuable insights potential versatile ingredient cosmetic industries. utilization these innovative not only offers but also promotes approaches skincare.

Language: Английский

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JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 15, 2024

Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated chemotherapeutics. Researchers have recently focused on the endocannabinoid system because its critical role in regulating our bodies' most important functions, including pain. We used vitro and vivo methods to determine toxicity profile synthetic cannabinoid, JWH-182, whether it could be potentially effective for CINP alleviation. In vitro, we evaluated JWH-182 general toxicity, measuring fibroblast viability various concentrations compound, neuroprotection dorsal root ganglion neurons paclitaxel. vivo, performed an evaluation acute 28-day repeated dose mice, monitoring health status complete histopathological examination. Finally, efficacy model mice using specific assessment tests. has acceptable profile, both, studies was able significantly reduce perception mice. However, translation these results clinic needs further investigation.

Language: Английский

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