Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 29, 2024
This
study
aims
to
develop
a
sustained
release
patch
for
bisoprolol
(BSP)
address
the
issue
of
blood
pressure
fluctuations
caused
by
traditional
dosing
methods,
ensuring
continuous
drug
and
efficient
utilization.
Long-chain
saturated
fatty
acids
(C6–C12)
were
chosen
as
counterions
precisely
control
BSP's
permeation
rate
in
formulation,
ion-pairing
strategy's
mechanism
delivery
was
thoroughly
investigated.
Molecular
docking
results
revealed
significant
differences
adsorption
capacities
different
ion
pairs
stratum
corneum
(SC)
epidermis,
directly
influencing
their
residence
times
thereby
regulating
passive
diffusion
rate.
Particularly,
BSP-C10
pair
successfully
reduced
one-third
its
baseline.
To
enhance
efficiency
reduce
costs,
chemical
enhancers
(CPEs)
are
typically
added
patches.
In
contrast
static
analyses
based
on
cumulative
permeation,
this
utilized
ATR-FTIR
dynamic
detection
isopropyl
myristate
(IPM)
preferred
enhancer,
studying
disruptive
effects
skin
barrier
during
delivery.
The
observed
that
delivery,
interaction
between
IPM
lipids
follows
U-shaped
trend:
initially
increasing,
then
decreasing,
with
peak
occurring
at
10
h.
Similarly,
displays
comparable
pattern.
addition
CPE
increased
utilization
from
39.8
±
4.31
79.8
7.27%.
strategy
rapidly
initial
phase
subsequent
weakening
disruption,
allowing
dominate
maintain
stable
long-term
therapeutic
effects.
Pharmacokinetic
studies
demonstrated
newly
developed
BSP
maintains
concentrations,
reduces
burst
effects,
increases
bioavailability
84.679%,
doubles
MRT0–t,
halves
Cmax,
significantly
occurrence
fluctuations.
European Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107036 - 107036
Published: Feb. 1, 2025
Cannabidiol
(CBD),
one
of
the
main
actives
from
Cannabis
sativa
has
been
perpetually
explored
lately
for
its
therapeutic
effects.
Its
attributes,
such
as
anti-inflammatory
and
antioxidant
effects,
snowball
into
pain
management,
epilepsy
seizure
alleviation,
anxiety
relief,
well
numerous
other
implications
through
entire
metabolism.
However,
conventional
administration
routes
challenge
potential,
with
reported
poor
water
solubility,
hepatic
degradation,
gastric
instability
erratic
bioavailability
observed
in
oral
administration.
As
a
result,
transdermal
delivery
systems
have
emerged
promising
alternative
to
or
inhaled
routes,
offering
improved
targeted
The
medical
use
CBD
throughout
Europe,
UK,
USA
Australia
is
extensive
usually
represented
by
pharmaceutical
preparations
recommended
after
treatment
routs
fail.
non-medical
limited
each
country's
own
legislation,
wider
range
products
being
available,
but
irregular
regulatory
landscape
coupled
growing
market
cannabinoid-infused
products,
emphasizes
need
standardized
formulations
further
clinical
research.
present
work
critically
examines
cannabidiol,
explores
skin's
potential
route
strategies
involved
using
it
systemic
targeting.
We
highlighted
key
challenges
provided
insights
CBD`s
variable
based
on
different
methods,
thus
compiling
literature-based
absorption,
distribution,
metabolism,
excretion
(ADME)
study.
also
explore
role
endocannabinoid
system,
function
various
conditions,
effects
associated
CBD,
particularly
light
varying
legislation
across
countries.
While
breadth
benefits
compelling,
essential
emphasize
ongoing
nature
research
individual
responses
can
vary
significantly.
Life,
Journal Year:
2024,
Volume and Issue:
14(3), P. 402 - 402
Published: March 18, 2024
We
are
exposed
to
a
mixture
of
environmental
man-made
and
natural
xenobiotics.
experience
wide
spectrum
exposure
in
our
lifetime,
including
the
effects
xenobiotics
on
gametogenesis
gametes
that
undergo
fertilization
as
starting
point
individual
development
and,
moreover,
utero
exposure,
which
can
itself
cause
first
somatic
or
germline
mutation
necessary
for
breast
cancer
(BC)
initiation.
Most
metabolized
or/and
bioaccumulate
biomagnify
tissues
cells,
tissues,
so
xenobiotic
metabolism
plays
an
important
role
BC
initiation
progression.
Many
considerations
necessitate
more
valuable
explanation
regarding
molecular
mechanisms
action
act
genotoxic
epigenetic
carcinogens.
Thus,
exposomics
exposome
concept
based
diversity
range
exposures
physical
factors,
synthetic
chemicals,
dietary
components,
psychosocial
stressors,
well
their
associated
biologic
processes
pathways.
Existing
evidence
risk
(BCR)
suggests
food-borne
chemical
carcinogens,
air
pollution,
ionizing
radiation,
socioeconomic
status
closely
related
carcinogenesis.
The
aim
this
review
was
depict
dynamics
kinetics
several
involved
development,
emphasizing
new
omics
fields
exposomics,
such
toxicogenomics,
epigenomics
interactomics,
metagenomics,
nutrigenomics,
nutriproteomics,
nutrimiRomics.
mainly
focused
food
nutrition,
endocrine-disrupting
chemicals
(EDCs),
development.
Overall,
cell
tissue
accumulation
biotransformation
lead
modifications
composition
morphology,
DNA
damage
genomic
instability,
epimutations,
RNA-mediated
extracellular
vesicle
effects,
aberrant
blood
methylation,
stimulation
epithelial-mesenchymal
transition
(EMT),
disruption
cell-cell
junctions,
reorganization
actin
cytoskeleton,
metabolic
reprogramming,
overexpression
mesenchymal
genes.
Moreover,
into
cells
impacts
almost
all
known
carcinogenic
Conversely,
food,
there
many
bioactive
compounds
with
anti-cancer
potential,
exerting
pro-apoptotic
roles,
inhibiting
cycle
progression
proliferation,
migration,
invasion,
damage,
stress
conditions.
conclude
has
high
potential
demonstrate
how
acts
double-edged
sword,
promoting
suppressing
tumorigenesis
BC.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(10), P. 1827 - 1827
Published: Oct. 4, 2023
Cannabis
sativa,
a
versatile
plant
with
numerous
varieties,
holds
promising
potential
for
wide
range
of
biological
activity.
As
raw
materials
research,
we
chose
leaves
and
inflorescences
hemp
varieties
such
as
Białobrzeskie,
Henola,
Tygra,
which
are
cultivated
mainly
their
fibers
or
seeds.
The
choice
extraction
is
key
step
in
obtaining
the
selected
compositions
active
compounds
from
material.
Bearing
mind
lipophilic
nature
cannabinoids,
performed
supercritical
carbon
dioxide
(scCO2)
at
50
°C
under
2000
(a)
6000
PSI
(b).
cannabinoid
contents
were
determined
use
HPLC-DAD
method.
antioxidant
capabilities
assessed
through
series
procedures,
including
DPPH,
ABTS,
CUPRAC,
FRAP
methods.
capacity
to
inhibit
enzymes
that
play
role
progression
neurodegenerative
diseases,
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase
was
also
studied.
dominant
cannabinoids
extracts
cannabidiol
(CBD)
cannabidiolic
acid
(CBDA).
highest
concentration
eight
detected
Tygra
extract
most
notable
properties
provided
by
Nonetheless,
it
Henola
(b)
demonstrated
efficient
inhibition
AChE
BChE,
inhibited
significantly
Białobrzeskie
Multidimensional
comparative
analysis
enrolled
all
assays
revealed
showed
substantial
neuroprotective
potential.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 748 - 748
Published: May 31, 2024
Known
for
its
natural
bio-compounds
and
therapeutic
properties,
hemp
is
being
utilized
in
the
development
of
skin
products.
These
products
offer
a
wide
range
applications
benefits
fields
bio-compounds,
pharmaceutical
technology,
topical
delivery
systems,
cosmeceuticals.
This
manuscript
deals
with
actives,
such
as
cannabinoids,
terpenes,
flavonoids,
their
diverse
biological
properties
relative
to
application,
including
anti-inflammatory,
antimicrobial,
antioxidant
effects.
Also,
paper
reviews
strategies
overcome
poor
penetration
well
integration
actives
cosmeceuticals
that
provide
sustainable
alternatives
traditional
skincare
offering
benefits,
anti-aging,
moisturizing,
soothing
properties.
The
review
aims
comprehensive
understanding
manufacturing
processes
containing
actives.
By
delving
into
science
behind
hemp-based
products,
provides
valuable
insights
potential
versatile
ingredient
cosmetic
industries.
utilization
these
innovative
not
only
offers
but
also
promotes
approaches
skincare.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 15, 2024
Abstract
Chemotherapy-induced
neuropathic
pain
(CINP),
a
condition
with
unmet
treatment
needs,
affects
over
half
of
cancer
patients
treated
chemotherapeutics.
Researchers
have
recently
focused
on
the
endocannabinoid
system
because
its
critical
role
in
regulating
our
bodies'
most
important
functions,
including
pain.
We
used
vitro
and
vivo
methods
to
determine
toxicity
profile
synthetic
cannabinoid,
JWH-182,
whether
it
could
be
potentially
effective
for
CINP
alleviation.
In
vitro,
we
evaluated
JWH-182
general
toxicity,
measuring
fibroblast
viability
various
concentrations
compound,
neuroprotection
dorsal
root
ganglion
neurons
paclitaxel.
vivo,
performed
an
evaluation
acute
28-day
repeated
dose
mice,
monitoring
health
status
complete
histopathological
examination.
Finally,
efficacy
model
mice
using
specific
assessment
tests.
has
acceptable
profile,
both,
studies
was
able
significantly
reduce
perception
mice.
However,
translation
these
results
clinic
needs
further
investigation.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1081 - 1081
Published: Aug. 17, 2024
This
systematic
review
critically
evaluates
preclinical
and
clinical
data
on
the
antibacterial
wound
healing
properties
of
cannabinoids
in
integument
wounds.
Comprehensive
searches
were
conducted
across
multiple
databases,
including
CINAHL,
Cochrane
library,
Medline,
Embase,
PubMed,
Web
Science,
LILACS,
encompassing
records
up
to
May
22,
2024.
Eighteen
studies
met
inclusion
criteria.
Eleven
animal
studies,
predominantly
utilizing
murine
models
(
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 649 - 662
Published: March 1, 2025
A
growing
number
of
publications
are
devoted
to
topical
cannabinoid
therapies
in
present-day
cosmetology,
as
they
appear
be
safe
and
effective
treatment
modalities
aimed
at
improving
the
comfort
quality
life
patients
with
atopic
dermatitis
(AD).
thorough
patient
interview,
physical
examination,
clinical
picture,
aetiopathogenesis
AD
allow
for
a
correct
diagnosis
enable
choice
least
invasive
pharmacological
treatment.
In
our
medical
experiment,
we
found
correlation
between
findings
studies
by
other
authors
validation
hypothesis
that
therapy
is
prevention
management
flares.
analysis
obtained
results
provided
insights
into
extent
which
applied
ointment
influenced
improvement
skin's
biophysical
parameters
(hydration,
lipid
content,
transepidermal
water
loss,
erythema).
This
experimental
study
was
conducted
from
May
July
2022
included
group
nine
(five
men
four
women)
aged
20-
67-years-old
were
diagnosed
AD.
The
involved
transdermal
delivery
an
compounded
cholesterol
ointment,
30%
cannabidiol
(CBD),
5%
cannabigerol
(CBG),
hemp
seed
oil,
assessment
skin
parameters,
including
corneometry
(skin
hydration),
TEWL,
sebumetry,
pH
(acidity).
preliminary
pilot
points
potential
employing
ointments
creams
containing
CBD
CBG
alternatives
conventional
auxiliary
during
both
flare-ups
remission.
achieved
improved
hydration,
sebum
level,
TEWL
well
reduced
erythema
studied
areas
(forearms).
Our
demonstrate
reducing
itching
AD,
leading
symptom
remission
some
cases.
