Recovery, Bioactivity, and Utilization of Bioactive Phenolic Compounds in Citrus Peel DOI Creative Commons

Nihal Durmus,

Zehra Gulsunoglu‐Konuskan, Meral Kılıç‐Akyılmaz

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(12), P. 9974 - 9997

Published: Nov. 7, 2024

ABSTRACT Citrus peels are rich in bioactive phenolic compounds with various health effects including antioxidant, antiobesity, antiinflammatory, antihypertensive, antihypercholesterolemic, antimicrobial, antidiabetic, and anticarcinogenic activities. Both extractable nonextractable phenolics present significant amounts peel diverse bioactivities. While can be recovered from the fruit by conventional extraction methods, remaining residues must released cell matrix first hydrolysis acid, alkali, or enzymes. Novel processing technologies help improvement of efficiency. Extreme process medium conditions degrade their bioactivity where encapsulation applied to improve stability, solubility, bioactivity. powder ascorbic acid dietary fiber besides extracts therefrom used as functional food ingredients extend shelf life provide benefits. In addition, antioxidant antimicrobial agents active packaging applications. Phenolic have also a potential nutraceuticals pharmaceuticals. this review, different forms peels, recovery, possible applications for upcycling industry presented.

Language: Английский

Anti-Inflammatory and Anti-Fibrotic Effects of a Mixture of Polyphenols Extracted from “Navelina” Orange in Human Hepa-RG and LX-2 Cells Mediated by Cannabinoid Receptor 2 DOI Open Access
Ilenia Saponara, Emanuela Aloisio Caruso, Miriam Cofano

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 512 - 512

Published: Jan. 9, 2025

Navelina oranges (Citrus sinensis) are rich in phytonutrients and bioactive compounds, especially flavonoids like hesperidin. This study investigates the anti-inflammatory anti-fibrotic properties of hesperidin (HE) a polyphenol mixture from (OE) human hepatocytes (Hepa-RG) hepatic stellate cells (LX-2), order to elucidate underlying molecular mechanisms. In Hepa-RG cells, HE treatment increased expression cannabinoid receptor 2 (CB2R), which was associated with down-regulation p38 mitogen-activated protein kinases (p38 MAPK) but had minimal impact on cyclooxygenase-2 (COX-2) transforming growth factor-β (TGF-β) levels. Conversely, OE not only enhanced CB2R levels reduced MAPK, also promoted significant reduction both COX-2 TGF-β levels, suggesting that might be more effective mitigating inflammatory fibrotic processes than HE. LX-2 caused notable decrease reflecting its efficacy targeting fibrosis-associated inflammation. treatment, other hand, Nuclear Factor-Kappa B p65 (NF-κB) expression, critical transcription factor involved responses, though it did significantly affect COX-2. induced fibrosis treated showed several markers. addition, antioxidant effects by increasing Cu, Zn superoxide dismutase (SOD1), Mn (SOD2) catalase (CAT) influencing state lipid peroxidation. Further research is needed explore treatments activated vivo liver disease models.

Language: Английский

Citations

0
Comparative study of essential oil extraction from lime peel ( Citrus amblycarpa Hassk. Ochse): Impact on chemical composition and bioactivities of anti-tyrosinase, anti-elastase, and antimicrobial properties DOI
Roshamur Cahyan Forestrania,

Marlisa Sintikhe Kaleb,

Adara Permata Halimatunnisa

et al.

Journal of Essential Oil Bearing Plants, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Jan. 29, 2025

Language: Английский

Citations

0
Sustainable farming practices: nurturing the future of functional foods DOI
Anka Trajkovska Petkoska, Biljana Trajkovska, Hyrije Koraqi

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 423 - 448

Published: Jan. 1, 2025

Language: Английский

Citations

0
Citrus endogenous components as prebiotics: Advances in extraction, digestion, mechanisms, and delivery DOI

Weiyun Zhang,

Jin‐song Liao,

Jun‐Ru Qi

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116141 - 116141

Published: March 1, 2025

Language: Английский

Citations

0
Microbial conversion of Limonene-containing waste into transesterifiable bio-lipids: Evaluating oleaginous bacterial isolates DOI

Faqin Lian,

Samia Qadeer,

Muzammil Anjum

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: March 14, 2025

Language: Английский

Citations

0
Phytochemical constituents and potential applications of Thomson Navel orange (Citrus × aurantium var. sinensis L.) peel extracts: Antioxidant, antimicrobial and antiproliferative properties DOI
Ibtissem Chakroun, Zied Bouraoui,

Takwa Ayachi

et al.

Industrial Crops and Products, Journal Year: 2023, Volume and Issue: 206, P. 117597 - 117597

Published: Oct. 13, 2023

Language: Английский

Citations

9
Volatile chemical profiling and distinction of Citrus essential oils by GC analyses with correlation matrix; evaluation of its in vitro radical scavenging and microbicidal efficacy DOI Creative Commons

A.R. Amala Dev,

Joseph Sonia Mol

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101460 - 101460

Published: Jan. 1, 2024

Leaf volatile oil compositions of five Citrus species viz., aurantifolia, limon, maxima, medica and * limon were examined in this study by Gas Chromatography-Flame Ionisation Detector (GC-FID) Chromatography-Mass Spectrometry (GC–MS) analysis percentage compared. Thirty-eight compounds identified that account for 90 to 99 % essential composition from species, respectively. GC–MS profiling oils revealed leaf predominantly characterized limonene (15.76±0.01% 29.36±0.46%) as one the major constituents. Monoterpenoids (77.38±0.19% 98.05±0.05%) are prominent class constituents present four plants under whereas (C. maxima), sesquiterpene hydrocarbons (38.97±0.21%) dominant category. The data GC analyses subjected correlation analyse between among selected species. These initially evaluated their antioxidant capacity exhibited promising radical scavenging property with an average IC50 value 29.15±0.01 μg/mL. This was further designed evaluate antimicrobial efficacy against various pathogenic bacterial fungal strains. Four gave a comparative antibacterial activity minimum inhibitory concentration (MIC) tested strains ranging 3.62±0.02mg/mLto 60.0±0.32mg/mL. found be more sensitive Escherichia coli MIC values ranged 3.62±0.03 10.15±0.02 mg/mL. also strong potential strains, Aspergillus niger Candida albicans, 3.22±0.02 28.17±0.04 Out screened study, them have shown significant activities which can attributed synergistic monoterpenoid these geranial, neral, citronellal, nerol, geraniol, geranyl formate rather than dominated oil. Based on findings obtained conclusions derived, it is evident natural agents fight free damage antibiotic-resistant microbes.

Language: Английский

Citations

3
Formulation and Characterization of Non-Toxic, Antimicrobial, and Alcohol-Free Hand Sanitizer Nanoemulgel Based on Lemon Peel Extract DOI Creative Commons
Faten M. Ibrahim, Eman Samy Shalaby, Mohamed Azab El‐Liethy

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(2), P. 59 - 59

Published: April 12, 2024

Recently, hand sanitization has gained attention for preventing disease transmission. Many on-the-market convenient dermal sanitizers contain alcohol, which can be detrimental to the skin. Therefore, three nanoemulgel formulations (LN-F1, LN-F2, LN-F3) incorporating lemon peel extract (LE), and with various increasing concentrations of xanthan gum as a gelling agent stabilizer, were developed characterized novel alternative. All showed non-Newtonian shear-thinning flow behavior, particle size values below 200 nm, zeta potential higher concentrations. exhibited greater in vitro phenolic compound release than free LE. LN-F2 (1.0% LE, 20.0% mineral oil, Span 80, 4.0% Cremophor RH 40, PEG 400, 0.5% gum, 50.5% dH2O) was selected optimal formulation due improved characteristics. LE cytotoxicity assessed on MA-104, showing no significant cellular morphological alterations up 10 mg/mL both samples. antimicrobial activity against E. coli, S. Typhimurium, P. aeruginosa, aureus, L. monocytogenes, C. albicans, well antiviral phiX 174, but effect rotavirus (SA-11). In vivo, presented removal capacity 83% 100% bacteria 89% fungi. These findings suggest that formulated holds safe effective antiseptic, providing viable alternative commercial alcohol-based formulations.

Language: Английский

Citations

3
When sustainability meets health and innovation: The case of Citrus by-products for cancer chemoprevention and applications in functional foods DOI
Teresa D’Amore, Moufida Chaari, Geppino Falco

et al.

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 58, P. 103163 - 103163

Published: April 15, 2024

Language: Английский

Citations

2
Active and machine learning-enhanced discovery of new FGFR3 inhibitor, Rhapontin, through virtual screening of receptor structures and anti-cancer activity assessment DOI Creative Commons
Qingxin Zeng, Haichuan Hu,

Zhengwei Huang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: June 11, 2024

Introduction: This study bridges traditional remedies and modern pharmacology by exploring the synergy between natural compounds Ceritinib in treating Non-Small Cell Lung Cancer (NSCLC), aiming to enhance efficacy reduce toxicities. Methods: Using a combined approach of computational analysis, machine learning, experimental procedures, we identified analyzed PD173074, Isoquercitrin, Rhapontin as potential inhibitors fibroblast growth factor receptor 3 (FGFR3). Machine learning algorithms guided initial selection, followed Quantitative Structure-Activity Relationship (QSAR) modeling molecular dynamics simulations evaluate interaction stability Rhapontin. Physicochemical assessments further verified its drug-like properties specificity. Results: Our experiments demonstrate that Rhapontin, when with Ceritinib, significantly suppresses tumor activity NSCLC while sparing healthy cells. The physicochemical evaluations confirm Rhapontin’s favorable FGFR3, highlighting an effective adjunct therapy. Discussion: integration established cancer therapies offers promising avenue for enhancing treatment outcomes NSCLC. By combining ancient wisdom precision science, this contributes evolving paradigms, potentially mitigating side effects associated current therapies.

Language: Английский

Citations

1