Emerging Biomarkers and Targeted Therapies Reshaping Clinical Management of Colorectal Cancer DOI Open Access

Tamer A. Addissouky

Cancer Research and Cellular Therapeutics, Journal Year: 2023, Volume and Issue: 8(2), P. 01 - 06

Published: March 20, 2023

Background: Colorectal cancer (CRC) is a leading cause of deaths worldwide. Key risk factors include lifestyle, diet, inflammation, and family history. Understanding molecular pathways underlying CRC initiation progression critical to guide prevention treatment. Purpose: This review summarizes recent advances in screening, therapy, future directions. Main body: New stool DNA panels blood-based assays offer non-invasive options for early detection, though require further validation. Immuno- targeted therapies matched tumor profiles have transformed metastatic Pembrolizumab elicits durable responses mismatch repair-deficient tumors, anti-EGFR antibodies cetuximab/panitumumab improve outcomes left-sided RAS/RAF wild-type CRC. Larotrectinib entrectinib are highly active NTRK fusion-positive Research focusing on new immunotherapies, leveraging the microbiome, combining multi-omics data enable precision medicine holds promise. Disparities across groups remain challenge. Conclusions: Recent therapeutic significantly improved survival patients. Advances diagnostics, next-generation sequencing, computational approaches will more sophisticated profiling tailored therapy selection. Realizing potential emerging immunotherapies integrating knowledge microbiome important frontiers.

Language: Английский

Application of Box-Behnken design for optimization of Vernonia amygdalina stem bark extract in relation to its antioxidant and anti-colon cancer activity DOI Creative Commons
Muhammad Fauzan Lubis, Sumaiyah Sumaiyah, Lokot Donna Lubis

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(4), P. 105702 - 105702

Published: March 7, 2024

Vernonia amygdalina is a popular plant used both in traditional medicine and as culinary herb, one of which anticancer. Microwave-assisted extraction (MAE) reported to have the advantage producing extracts with better phenol flavonoid content so that anticancer potential extract increases. This study was conducted produce polyphenol-rich V. stem bark an Responses Surface Methodology (RSM) determine optimum conditions for extracting phenolics flavonoids from bark. The total phenolic contents were carried out using colorimetry assay. antioxidant activity optimal (VABEEo) non-optimum (VABEE) determined DPPH method support its activity. Meanwhile, VABEEo established through several tests cytotoxic test MTT assay, cell cycle arrest apoptosis flow cytometer, protein expression immunocytochemical analysis. research informs highest yield, (TPC), (TFC) obtained respectively at 7.402 g, 73.634 mg GAE/g, 64.466 QE/g microwave power 450 W 3 min solvent concentration 76.19 %. In addition, 25.413 ± 0.525 µg/mL, higher than VABEE 41.254 0.614 µg/mL. vitro studies show inhibits colon cancer growth by inducing G1 stages, increasing apoptosis, decreasing Cyclin D1/p53 levels. showed application RSM successful preparation MAE. Moreover, indicates promising further treatment via tests.

Language: Английский

Citations

5
Phytocompounds and Nanoformulations for Anticancer Therapy: A Review DOI Creative Commons
Giuseppina Bozzuto, Annarica Calcabrini, Marisa Colone

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3784 - 3784

Published: Aug. 9, 2024

Cancer is a complex disease that affects millions of people and remains major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, radiotherapy, have limited achievements multiple drawbacks, among which are healthy tissue damage multidrug-resistant phenotype onset. Increasing evidence shows many plants’ natural products, as well their bioactive compounds, promising anticancer activity exhibit minimal toxicity compared to conventional drugs. However, widespread use in therapy severely restricted by limitations terms water solubility, absorption, lack stability, bioavailability, selective targeting. The nanoformulations for product transportation delivery could be helpful overcoming these limitations, thus enhancing therapeutic efficacy providing the basis improved treatment strategies. present review aimed at an update on some phytocompounds (curcumin, resveratrol, quercetin, cannabinoids, others) main showing antitumor activities, both vitro vivo, against such different human types breast colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, osteosarcoma. intracellular pathways underlying phytocompound advantages nanoformulation employment also examined. Finally, this critically analyzes research gaps causing success phytocompounds’ nanoformulations’ clinical translation.

Language: Английский

Citations

4
Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma DOI Creative Commons

Guodan Zeng,

Xinyu Liu, H. Lv

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 61 - 61

Published: Jan. 13, 2025

miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These significantly influence cell cycle tumor cells control programmed death (apoptosis). Currently, research on has become a major focus developing cancer therapies. Osteosarcoma, malignant neoplasm predominantly occurring during adolescence later life, is characterized by high propensity for metastasis. This review explores role initiation progression cancer, highlighting their potential as predictive biomarkers disease. It discusses mechanisms which natural products modulate miRNA activity to apoptosis, ferroptosis, autophagy osteosarcoma cells, aiming identify new strategies treatment. Recent studies how regulate reduce resistance chemotherapy also reviewed. Furthermore, elaborates m6A modifications expression, thereby exerting antitumor effects. In this process, interactions between identified, both jointly influencing tumorigenesis progression, offering perspective approaches could help uncover novel regulatory pathways provide theoretical foundation drugs identifying therapeutic targets.

Language: Английский

Citations

0
Optimizing medical image analysis through MViTX on multiple datasets with explainable AI DOI
Md. Alif Sheakh, Mst. Sazia Tahosin,

Mohammad Jahangir Alam

et al.

Neural Computing and Applications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

0
Leveraging Cholesterol-Functionalized Cyclodextrin Nanosponges for Enhanced Drug Delivery in Cancer Cells DOI Open Access
Ilona Krabicová, Yousef Khazaei Monfared, Fabrizio Caldera

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1213 - 1213

Published: Jan. 30, 2025

Cholesterol, the essential building block of cellular membranes, has proven to be a useful tool for increasing biocompatibility and bioavailability drug delivery systems in cancer treatment. Resveratrol, natural polyphenolic compound with promising anticancer properties, faces significant limitations due its low solubility bioavailability, hindering clinical utility. Therefore, present study, we aimed design cholesterol-functionalized cyclodextrin nanosponges (Chol-NSs) tunable cholesterol content optimize resveratrol encapsulation delivery. Both formulations, free carbonyl diimidazole (CDI) NSs functionalized Chol-NSs, demonstrated high loading efficiency. In vitro experiments revealed that incorporation significantly improved uptake nanocarriers potentiated cytotoxic effects on breast cells. Importantly, both CDI even at varying percentages, safe profile against fibroblast cell lines. These results indicate represent platform effective compounds therapy.

Language: Английский

Citations

0
Natural compounds as regulators of miRNAs: exploring a new avenue for treating colorectal cancer DOI
Ahmed S. Doghish,

Sherif S Abdel Mageed,

Osama A. Mohammed

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0
Phillyrin from Forsythia suspensa suppresses the proliferation, angiogenesis, and metastasis of colorectal cancer via targeting CD147 DOI
Yuzhen Huang, Nan Cheng, Yingru Zhi

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119759 - 119759

Published: April 1, 2025

Language: Английский

Citations

0
An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update DOI Creative Commons
Susmita Roy, Dikshita Deka, K. Suresh Babu

et al.

Epigenetics, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 16, 2025

Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes critical role of epigenetic mechanisms its pathogenesis and progression. This also describes potential natural compounds altering landscape, focused mainly on DNA methylation, histone modification, non-coding RNAs. Publications from previous five years were searched retrieved using well-known search engines databases like PubMed, Google Scholar, ScienceDirect. Keywords CRC/colorectal cancer, CAC/Colitis associated inflammasomes, modulation, genistein, curcumin, quercetin, resveratrol, anthocyanins, sulforaphane, epigallocatechin-3-gallate used combinations during search. These predominantly affect pathways such as Wnt/β-catenin, NF-κB, PI3K/AKT suppress CRC cell proliferation oxidative stress enhance anti-inflammation apoptosis. However, their clinical use is restricted due low bioavailability. multiple methods exist overcome challenges this, including but not limited structural modifications, nanoparticle encapsulations, bio-enhancers, novel advanced delivery systems. improve supportive therapies that target progression epigenetically with fewer side effects. Current research focuses enhancing targeting control while minimizing effects, emphasizing improved specificity, bioavailability, efficacy standalone or synergistic therapies.

Language: Английский

Citations

0
The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance DOI Creative Commons
Zhong Chen,

Guojuan Wang,

Min Guo

et al.

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

Background: Colorectal cancer is a major cause of mortality among the prevalent malignant tumors gastrointestinal tract. Although chemotherapy standard treatment for colorectal cancer, its efficacy limited by chemoresistance. Recent studies have investigated targeting tumor stem cells as potential new therapeutic approach addressing chemoresistance in cancer. frequently relapses, with often representing one leading causes failure. Purpose: Understanding drug resistance crucial improving outcomes. By focusing on developing targeted therapies that specifically address cells, there to make significant advancements cancer.This may lead more effective and lasting outcomes patients battling Research Design: In this review, comprehensive overview recent research cell presented.Results: Elucidating key underlying mechanisms. This review also highlights benefits overcoming treatment. Conclusions: CCSCs are players CRC, indicating their targets therapy. role process could aid discovering tailored strategies.The significance signaling pathways, TME, miRNA regulating been highlighted.

Language: Английский

Citations

2
Mushrooms and Colorectal Cancer: Unveiling Mechanistic Insights and Therapeutic Innovations DOI Creative Commons

Samridhi Kurl,

S. Kaur,

Neeraj Mittal

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Nature has bestowed us with an abundant reservoir of resources that besides having nutritional value, are prolific mines bioactive constituents a plethora medicinal activities. Mushrooms have been used since centuries in traditional system medicine for their purported health benefits including anticancer Thorough research, spanning over Japan, China, Korea, and the USA, established unique properties mushrooms extractives prevention treatment various types cancer. The aim review article is to provide comprehensive overview existing literature highlighting potential relationship between colorectal Different databases such as PubMed, Web Science, Google Scholar, ScienceDirect were searched total 62 articles two book chapters reviewed, data extracted. Multiple studies demonstrated exhibit activities, effectively reducing adverse side effects nausea, myelosuppression, anemia, sleeplessness. Furthermore, they shown mitigate drug resistance following chemotherapy radiation therapy. Certain species Antrodia, Pleurotus, Ganoderma, Lentinula, Hericium, Cantharellus, Clitocybe, Coprinopsis, Trametes, Sparassis, Lactarius, so on manifest activity colon. can help improve scientific understanding co-relationship This may advancing research directions integrating mushroom-based strategies into current protocols

Language: Английский

Citations

2