Assessment of Antihyperglycemic and Modulatory Effects of trans‐Ferulic Acid on Glibenclamide and Metformin: In Vivo and Molecular Docking Studies DOI
Md. Sakib Al Hasan, Md. Shimul Bhuia, Salehin Sheikh

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, resistance, or both. trans ‐Ferulic acid (TFA) has several biological activities, including sedative, anxiolytic, anti‐inflammatory, and so on. However, there no in vivo silico study on the antihyperglycemic activity of TFA. This assessed antidiabetic potential TFA its modulatory effect glibenclamide (GLI) metformin (MET) through hypoglycemic tests mice molecular docking targeting glucose metabolism proteins. (25, 50, 75 mg/kg, p.o.) was tested glucose‐induced hyperglycemic alongside GLI (10 MET (100 p.o.), with blood levels (BGLs) monitored. significantly ( p < 0.05) reduced BGLs dose‐dependent manner, mg/kg dose achieving 30.99% reduction at 180 min, compared 52.04% 55.27% (MET). Combination therapy (TFA‐50+GLI‐10 TFA‐50+MET‐100) further enhanced glucose‐lowering effects, TFA‐50+GLI‐10 showing highest (58.90%). In analysis revealed that exhibited elevated binding affinities complex I (−6.4 kcal/mol) mitochondrial glycerol‐3‐phosphate dehydrogenase (−6.8 kcal/mol). These findings suggest significant potential, supporting role regulation.

Language: Английский

Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential DOI Open Access

Muahmmad Ali Khan,

Dina M. El‐Kersh, Md. Shafiqul Islam

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(11)

Published: Sept. 16, 2023

Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches skin, chicken pox, healing sores wounds, colds fever, nausea, jaundice, rheumatism, respiratory ailments. This study aimed at summarizing traditional uses, phytochemical profile, biological activities M. based on obtainable information screened from different databases. An up-to-date search was performed in PubMed, Science Direct, clinicaltrials.gov, Google Scholar databases with specific keywords. No language restrictions were imposed. Published articles, theses, seminar/conference papers, abstracts, books ethnobotany, phytochemistry pharmacological evidence considered. Based inclusion criteria, this includes 53 published records above-mentioned The results suggest that fresh leaves whole plant are frequently used folk medicine. contains more than 150 phytochemicals under following groups: essential oils, phenolics flavonoids, terpenes, terpene lactones, glycosides, sulfated flavonoids. It carbohydrates micronutrients vitamins major trace minerals. possesses antioxidant, anti-inflammatory, anti-microbial, anti-dermatophytic, anti-protozoal, anthelmintic, cytotoxic, anxiolytic, anti-diabetic, lipid-lowering antidiabetic, spasmolytic, memory-enhancing, wound-healing, anti-aging, thrombolytic activities. clinical studies have been reported to date. might be one potential sources phytotherapeutic compounds against diverse humans. Studies required confirm its safety profile experimental animals prior initiating trials. Moreover, adequate investigation also crucial clarify exact mechanism action each effect.

Language: Английский

Citations

16
Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations DOI Creative Commons
Muhammad Torequl Islam, Mehedi Hasan Bappi, Md. Shimul Bhuia

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: June 25, 2024

Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and inflammatory processes. This study aimed to evaluate anti-inflammatory effects possible molecular mechanisms of THY via formalin-induced mouse egg albumin-induced chick models alongside docking dynamic (MD) simulations. (7.5, 15, 30 mg/kg) was investigated, compared celecoxib ketoprofen (42 mg/kg), standards. dose-dependently significantly ( p &lt; 0.05) decreased paw-licking edema diameter parameters in formalin (phases I II) models. Moreover, (15 exerted better combination with standard drug than alone celecoxib. In silico studies demonstrated elevated binding affinities cyclooxygenase-2 (COX-2) COX-1 enzyme, ligand binds at a similar location where interact. The results MD simulations confirmed stability test ligand. on Swiss mice young chicks, possibly by interacting COX-2. As conclusion, might be hopeful candidate for management disorders.

Language: Английский

Citations

5
Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms DOI Creative Commons

Tanzila Akter Eity,

Md. Shimul Bhuia, Raihan Chowdhury

et al.

Journal of Tropical Medicine, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties was beneficial numerous degenerative diseases by preventing lipid peroxidation. Quercetin is different diseases, such as atherosclerosis chronic inflammation. This study aims to find out anticancer activities quercetin determine mechanisms pathways which are responsible for effect. It also revealed biopharmaceutical, toxicological characteristics, clinical utilization evaluate its suitability further investigations reliable drug. All relevant data concerning this compound with cancer collected using scientific search engines, including PubMed, Springer Link, Wiley Online, Web Science, SciFinder, ScienceDirect, Google Scholar. review demonstrated that strong properties, apoptosis, inhibition cell proliferation, autophagy, cycle arrest, angiogenesis, invasion migration against various types cancer. Findings could significantly moderate regulate pathways, PI3K/AKT‐mTORC1 pathway, JAK/STAT signaling system, MAPK MMP NF‐ κ B p‐Camk2/p‐DRP1 pathway. However, poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation quercetin). Moreover, expressed no toxic effect investigated subjects. Based on view these findings, it might be considered chemotherapeutic drug candidate treatment cancers. more studies suggested establish proper efficacy, safety, human dose.

Language: Английский

Citations

5
Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies DOI
Muhammad Torequl Islam, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: unknown, P. 100090 - 100090

Published: Sept. 1, 2024

Language: Английский

Citations

4
Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Raihan Chowdhury

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

Citations

4
Exploring the Antiemetic Potential of Caffeic Acid: A Combined In Vivo and Computational Approach DOI Open Access
Md. Shimul Bhuia, Jannatul Ferdous, Raihan Chowdhury

et al.

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

ABSTRACT Background This study emphasizes evaluating the antiemetic efficacy of natural food component caffeic acid (CAF) using a copper sulfate pentahydrate (CuSO 4 .5H 2 O)‐induced emetic model on chicks, and an in silico approach was also adopted to estimate possible underlying mechanisms. Methods Two doses (25 50 mg/kg b.w.) CAF several referral drugs considered positive controls (PCs), including domperidone (6 mg/kg), hyoscine (21 aprepitant (16 diphenhydramine (10 ondansetron (5 were orally administered chicks. The vehicle served as control group. Co‐treatments with provided chicks evaluate modulatory action test compound. Results According results, delayed onset decreased frequency retches dose‐dependent manner compared (40 mg/kg) represented notable latency period (60.17 ± 3.16 s) diminished number retchings (18.33 1.74 times) Further, co‐treatments, increased reduced retches, except for domperidone. In investigation, showed binding affinity toward D (−7.3 kcal/mol), 5HT 3 (−7.1 M 5 (−7 kcal/mol) receptors same site ligand. Conclusion research indicated that has mild properties by interacting , 5TH receptors. Therefore, preclinical clinical studies are necessary assess effectiveness safety profile this ingredient.

Language: Английский

Citations

0
Modulatory Anxiolytic Effect of Aucubin on Diazepam in Swiss Albino Mice: Possible Mechanisms Through In Vivo Approach with Receptor Binding Affinity DOI

Dipu Bishwas,

Rubel Hasan, Md. Shimul Bhuia

et al.

Revista Brasileira de Farmacognosia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

0
Possible GABAkine‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches DOI Creative Commons
Muhammad Torequl Islam, Jannatul Ferdous, Md. Sakib Al Hasan

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

A previous report suggests that phytol (PHY) may exert its antidepressant effects in mice, possibly through GABAA receptor interaction pathways. We aimed to check effect with possible molecular mechanisms behavioral and silico studies. For this, adult mice were randomly divided into different groups (n = 6), namely control (vehicle), standards (DZP: diazepam at 2 mg/kg, FLU: flumazenil 0.1 FLUX: fluoxetine 20 mg/kg), PHY (25, 50, 75 combined (PHY-75 DZP-2 and/or FLU-0.1, FLUX-20). Thirty minutes after treatment, each animal was subjected tail suspension forced swimming tests, their immobility time (IMT) counted for 5 min. In studies performed the α1, α2, α3, α5, γ2 subunits 5HT1A investigate mechanisms. Additionally, vitro GABA activity of reference drugs also by using colorimetric method. The results demonstrated DZP significantly (p < 0.05) concentration-dependently inhibited GABA, while FLU alone or combination reversed it. dose-dependently reduced IMT both protocols, FLUX-20 showed lower compared DZP, indicating elevated locomotion mice. It a value male animals than female animals. sexes, mg/kg increased values DZP-2, reducing this parameter FLU-0.1. exhibited higher binding affinities α2 α3 receptors -6.5, -7.2 6.7 kcal/mol, respectively. Taken together, exerted sedative-like modulated GABAergic serotonergic drug FLUX. be potential candidate management depression.

Language: Английский

Citations

0
Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight DOI
Asma Aktar, Md. Shimul Bhuia, Raihan Chowdhury

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 16, 2024

Rosavin is an alkylbenzene diglycoside primarily found in Rhodiola rosea (L.), demonstrating various pharmacological properties a number of preclinical test systems. This study focuses on evaluating the effects rosavin and underlying molecular mechanisms based different non-clinical investigations. The findings revealed that has anti-microbial, antioxidant, protective effects, including neuroprotective against neurodegenerative ailments such as mild cognitive disorders, neuropathic pain, depression, stress, well gastroprotective, osteoprotective, pulmoprotective, hepatoprotective activities. effect due to its capability diminish inflammation oxidative stress. compound also manifested anticancer cancer via exerting cytotoxicity, apoptotic cell death, arresting phases (G

Language: Английский

Citations

3
Phytol exerts sedative-like effects and modulates the diazepam and flumazenil’s action, possibly through the GABAA receptor interaction pathway DOI
Muhammad Torequl Islam, Jannatul Ferdous, Md. Sakib Al Hasan

et al.

Neuroscience Letters, Journal Year: 2024, Volume and Issue: 842, P. 138007 - 138007

Published: Sept. 30, 2024

Language: Английский

Citations

3