Synthesis, photophysical properties, anticancer evaluation, and molecular docking studies of new pyrimidine linked 4‐arylidene‐thiazolidin‐4‐ones as potent anticancer agents
Luminescence,
Journal Year:
2024,
Volume and Issue:
39(1)
Published: Jan. 1, 2024
Abstract
The
reaction
of
4‐(chloroacetamido)pyrimidine
(1)
with
ammonium
thiocyanate
gave
2‐(pyrimidin‐4‐ylimino)thiazolidin‐4‐one
(2)
,
which,
when
condensed
four
substituted
benzaldehyde
analogues,
the
consequent
5‐arylidine‐2‐(pyrimidin‐4‐ylimino)thiazolidin‐4‐ones
3a–d
.
In
addition,
absorbance
and
fluorescence
behaviours
pyrimidinylimino‐thiazolidin‐4‐one
hybrids
in
various
organic
solvents
were
investigated.
emphasis
was
on
studying
UV
absorption
capacities
effect
structural
components
photophysical
qualities
such
as
5‐arylidene‐2‐(pyrimidin‐4‐ylimino)thiazolidin‐4‐ones
N
‐dimethylamino
tail.
cytotoxic
tumour
cell
lines
(HepG2,
HCT‐116,
PC3,
MCF‐7)
a
normal
line
(WI38)
is
investigated
this
work.
cytotoxicity
measured
by
comparing
half‐maximal
inhibitory
concentration
(IC
50
)
to
reference
medication,
5‐fluorouracil.
findings
indicate
that
these
hybrid
compounds
had
varying
effects
examined;
3b
3c
demonstrated
significant
anticancer
activity
against
MCF‐7
IC
values
7.53
±
0.43
9.17
0.31
μM,
respectively.
efficacy
synthesized
epidermal
growth
factor
receptor
(EGFR)
kinase
EGFR
crucial
target
cancer
treatment
because
inhibiting
it
may
reduce
development
proliferation.
value
used
calculate
activity,
which
inhibitor
necessary
induce
inhibition
activity.
predicted
ADME
results
show
have
good
pharmacokinetic
properties;
3d
more
lipophilic
than
other
compounds.
It
has
medium
molecular
weight,
small
number
hydrogen
bond
acceptors
donors,
large
aromatic
heavy
atoms.
Moreover,
docking
simulations
revealed
precise
information
interactions
5‐Fu
their
respective
protein
targets.
These
point
possible
pathways
for
biological
activities
call
testing
establish
effectiveness
bioactive
molecules
or
therapeutic
candidates.
Language: Английский
New Mercaptopyrimidine Derivatives Synthesized with Expected Antimicrobial and Antioxidant Properties and Theoretical Study
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
unknown, P. 140795 - 140795
Published: Nov. 1, 2024
Language: Английский
Review: Pyrimidine Derivatives as Anticancer Agents
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(1), P. 54 - 68
Published: Jan. 1, 2024
Cancer
is
a
disease
that
can
be
fatal
everywhere.It
start
in
almost
any
organ
or
tissue
of
the
body
when
abnormal
cells
grow
uncontrollably;
they
go
further
than
their
usual
boundaries
to
attack
contiguous
parts
and/or
slap-up
meal
other
organs.The
primary
problem
facing
current
treatment
techniques,
such
as
chemotherapy
and
radiation,
multidrug
resistance
(MDR).Finding
unique
varied
structural
framework
could
open
door
creation
fresh,
potent
anticancer
medications.Also,
knowledge
genomics
molecular
sciences
has
helped
creating
drug
targets.Pyrimidines,
class
nitrogen-containing
heterocyclic
compounds,
play
significant
role
crafting
cancer
drugs.These
synthetic
compounds
have
proven
effective
against
various
cancers,
including
myeloid
leukemia,
breast
cancer,
liver
pancreatic
idiopathic
pulmonary
fibrosis.This
review
presents
findings
several
investigations
conducted
between
2006
2023
on
pyrimidine
derivatives
corresponding
characteristics.
Language: Английский