International Journal of Drug Delivery Technology,
Journal Year:
2023,
Volume and Issue:
13(04), P. 1527 - 1532
Published: Dec. 25, 2023
The
current
study
aimed
to
increase
the
stability
and
therapeutic
efficacy
of
antitubercular
medication
rifampicin
by
reducing
or
preventing
its
breakdown
in
stomach
pH
state.
Ascorbic
acid
was
used
as
an
antioxidant
preparation
rifampicin-loaded
Poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
for
investigation.
A
multistep
emulsion
process
create
dig-laden
nanoparticles,
different
techniques
were
then
assess
final
product.
Ten
kinds
formulations
created
this
study.
According
study’s
findings,
ascorbic
can
rifampicin’s
bioavailability
acidic
conditions.
results
also
show
that
changing
concentration
makes
a
statistically
important
difference
way
medicine
breaks
down.
Schistosomiasis
is
one
of
the
most
neglected
parasitic
diseases
in
world.
The
new
tropical
road
map
2021–2030,
adopted
by
World
Health
Assembly,
set
global
goals
for
elimination
schistosomiasis.
current
treatment
options
like
praziquantel
schistosomiasis
are
limited.
This
review
on
nanoparticle-based
treatments
explores
various
upcoming
technologies.
Nanoparticle-based
and
vaccines
have
emerged
as
a
promising
approach
to
overcome
therapeutic
limitations
providing
targeted
sustained
delivery
drugs.
Using
literature
databases,
search
was
performed
using
syntax
Schistosoma,
praziquantel,
nanoparticles,
published
between
2010-
2023.
bibliometric
analysis
showed
that
there
has
been
decline
number
research
reports
clinical
trials
recent
years.
With
increased
funding
collaboration,
this
technology
can
be
used
develop
safe,
effective,
affordable
save
millions
lives.
Our
discussion
wants
raise
awareness
advocate
support
development
disease.
International Journal of Drug Delivery Technology,
Journal Year:
2023,
Volume and Issue:
13(04), P. 1527 - 1532
Published: Dec. 25, 2023
The
current
study
aimed
to
increase
the
stability
and
therapeutic
efficacy
of
antitubercular
medication
rifampicin
by
reducing
or
preventing
its
breakdown
in
stomach
pH
state.
Ascorbic
acid
was
used
as
an
antioxidant
preparation
rifampicin-loaded
Poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
for
investigation.
A
multistep
emulsion
process
create
dig-laden
nanoparticles,
different
techniques
were
then
assess
final
product.
Ten
kinds
formulations
created
this
study.
According
study’s
findings,
ascorbic
can
rifampicin’s
bioavailability
acidic
conditions.
results
also
show
that
changing
concentration
makes
a
statistically
important
difference
way
medicine
breaks
down.
