Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation DOI Creative Commons
Yuling Liu, Weiwei Su, Peibo Li

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 643 - 643

Published: May 16, 2024

Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang Danshen Tablet (FDT) a traditional Chinese medicine that has been clinically used to treat CVDs for more than 40 years. Nevertheless, owing complexity ingredients, pharmacological mechanism FDT in treatment not fully elucidated. In this study, an integrated strategy UFLC-Q-TOF-MS/MS, network pharmacology, molecular biology, and transcriptomics was elucidate mechanisms action atherosclerosis. total, 22 absorbed constituents were identified rat serum after oral administration FDT. silico, pharmacology studies have shown regulates four key biological functional modules atherosclerosis: oxidative stress, cell apoptosis, energy metabolism, immune/inflammation. animal experiments, exerted protective effects against atherosclerosis by reducing plaque area lipid levels ApoE

Language: Английский

Integrated network pharmacology and metabolomics analysis to reveal the potential mechanism of Ershen Wan in ameliorating ulcerative colitis DOI
Mingyang Wang,

Meiyu Wan,

Meijuan Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119690 - 119690

Published: March 1, 2025

Language: Английский

Citations

0
IL-17 enhanced the susceptibility to fluoxetine resistance in depression via the JAK1-STAT6 signaling pathway DOI
Mingjia Zhang, Yaonan Hong, Wenqi Yu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114513 - 114513

Published: April 14, 2025

Language: Английский

Citations

0
Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation DOI Creative Commons
Yuling Liu, Weiwei Su, Peibo Li

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 643 - 643

Published: May 16, 2024

Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang Danshen Tablet (FDT) a traditional Chinese medicine that has been clinically used to treat CVDs for more than 40 years. Nevertheless, owing complexity ingredients, pharmacological mechanism FDT in treatment not fully elucidated. In this study, an integrated strategy UFLC-Q-TOF-MS/MS, network pharmacology, molecular biology, and transcriptomics was elucidate mechanisms action atherosclerosis. total, 22 absorbed constituents were identified rat serum after oral administration FDT. silico, pharmacology studies have shown regulates four key biological functional modules atherosclerosis: oxidative stress, cell apoptosis, energy metabolism, immune/inflammation. animal experiments, exerted protective effects against atherosclerosis by reducing plaque area lipid levels ApoE

Language: Английский

Citations

2