Lipid-Based Nanoformulations of [6]-Gingerol for the Chemoprevention of Benzo[a] Pyrene-Induced Lung Carcinogenesis: Preclinical Evidence

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 574 - 574

Published: April 15, 2025

Background/Objectives: [6]-Gingerol ([6]-G), a bioactive compound derived from Zingiber officinale (ginger), exhibits strong anticancer potential but is hindered by poor aqueous solubility and low bioavailability. This study aimed to develop evaluate PEGylated liposomal [6]-G (6-G-Lip) enhance its stability, bioavailability, chemopreventive efficacy in benzo[a]pyrene (BaP)-induced lung carcinogenesis. Methods: 6-G-Lip was synthesized using modified thin-film hydration technique characterized for size, polydispersity index (PDI), zeta potential, encapsulation efficiency (EE%), release kinetics. The effects were assessed BaP-induced cancer Swiss albino mice, with prophylactic administration two weeks before BaP exposure through 21 weeks. Cancer biomarkers, antioxidant enzyme activity, reactive oxygen species (ROS) generation, induction of apoptosis, histopathological alterations analyzed. Results: exhibited particle size 129.7 nm, (PDI) 0.16, −18.2 mV, an (EE%) 91%, ensuring stability effective drug loading. formulation controlled profile, 26.5% 47.5% released PBS serum, respectively, at 72 h. significantly lowered restored defenses (SOD: 5.60 U/min/mg protein; CAT: 166.66 μm H2O2/min/mg protein), reduced lipid peroxidation (MDA: 3.3 nm/min/mg induced apoptosis (42.2%), highlighting efficacy. Conclusions: the first prepare, characterize, [6]-G-Lip chemoprevention cancer. It modulates oxidative stress, restores biochemical homeostasis, selectively induces apoptosis. These findings support as promising nanotherapeutic strategy prevention.

Language: Английский

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Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 957 - 968

Published: Dec. 19, 2023

Lipid nanoparticles (LNPs) hold great promise as carriers for developing drug delivery systems (DDSs) aimed at managing ischemic stroke (IS). Previous research has highlighted the vital role played by lipid composition and biophysical characteristics of LNPs, influencing their interactions with cells tissues. This understanding presents an opportunity to engineer LNPs tailored specifically enhanced IS treatment. We previously introduced innovative concept reconstituted (rLNPs), which not only retain advantages conventional but also incorporate lipids from originating cell or tissue. Brain-derived rLNPs (B-rLNPs) exhibit significantly superior accumulation within cerebral region when compared liver-derived (L-rLNPs). The homing effect B-rLNPs was then employed construct 3-n-butylphthalide (NBP) loaded DDS (B-rLNPs/NBP) treatment IS. Our results demonstrated that free NBP, B-rLNPs/NBP can reduce infarct volume, neurological deficits, blood-brain barrier (BBB) leakage rate, brain water content, neutrophil infiltration, alleviate pathological structures, improve motor function in MCAO/R model. proved showed further reinforced protective effects on same model than NBP through regulation TLR4/MyD88/NF-κB (anti-inflammation) Bax/Bcl-2 (anti-apoptosis) pathways. study offers a promising tool towards improved

Language: Английский

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A Simple Method for the Preparation and Characterization of Nanostructured Lipid Carriers (NLC) Formulations for Cutaneous Use

Journal of Chemical Education, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

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Effective Hydrogel Vascular Patch Dual‐Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Endovascular aneurysm repair (EVAR) plays a crucial role in the treatment of abdominal aortic (AAA) clinic, but remains patient's body after surgery, continuing to pose risk progression. Cycloastragenol (CAG) is proven be an effective anti-AAA drug, and its vascular protective effects can further improved when hydrophobic CAG encapsulated into nano-sized formulations enhance bioavailability. In this context, study developed extravascular patch hydrogel loaded with nanostructured lipid carriers hydrophilic drug doxycycline hydrochloride (DOX). The delivered onto mouse aortas promote local permeation hydrophilic/hydrophobic drugs at vessel sites provide protection against AAA injury induced by elastase. This introduces novel promising approach for treatment, which serve as supplementary strategy EVAR surgery.

Language: Английский

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