Anoctamin 1, a multi-modal player in pain and itch
Cell Calcium,
Journal Year:
2024,
Volume and Issue:
123, P. 102924 - 102924
Published: June 22, 2024
Anoctamin
1
(ANO1/TMEM16A)
encodes
a
Ca2+-activated
Cl-
channel.
Among
ANO1′s
many
physiological
functions,
it
plays
significant
role
in
mediating
nociception
and
itch.
ANO1
is
activated
by
intracellular
Ca2+
depolarization.
Additionally,
heat
above
44°C,
suggesting
as
another
activation
stimulus.
highly
expressed
nociceptors,
indicating
nociception.
Conditional
Ano1
ablation
dorsal
root
ganglion
(DRG)
neurons
results
reduction
acute
thermal
pain,
well
mechanical
allodynia
or
hyperalgesia
evoked
inflammation
nerve
injury.
Pharmacological
interventions
also
lead
to
nocifensive
behaviors.
functionally
linked
the
bradykinin
receptor
TRPV1.
Bradykinin
stimulates
via
IP3-mediated
release
from
stores,
whereas
TRPV1
combination
of
influx
release.
Nerve
injury
causes
upregulation
expression
DRG
neurons,
which
blocked
antagonists.
Due
its
nociception,
strong
specific
antagonists
have
been
developed.
pruritoceptors,
Mas-related
G
protein-coupled
receptors
(Mrgprs)-dependent
The
leads
chloride
efflux
depolarization
due
high
concentrations,
causing
pain
Thus,
could
be
potential
target
for
development
new
drugs
treating
Language: Английский
Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets
Acta Pharmacologica Sinica,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
Language: Английский
Exploring oak processionary caterpillar induced lepidopterism (part 2): ex vivo bio-assays unmask the role of TRPV1
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: June 28, 2024
As
human
skin
comes
into
contact
with
the
tiny
hairs
or
setae
of
oak
processionary
caterpillar,
Thaumetopoea
processionea,
a
silent
yet
intense
chemical
confrontation
occurs.
The
result
is
mix
issues:
rashes
and
an
itching
that
typically
lasts
days
weeks
after
contact.
This
discomfort
poses
significant
health
threat
not
only
to
humans
but
also
animals.
In
Western
Europe,
alarming
increase
in
outbreaks
extends
beyond
areas
near
infested
trees
due
dispersion
setae.
Predictions
indicate
sustained
rise
outbreaks,
fueled
by
global
changes
favoring
caterpillar's
survival
distribution.
Currently,
absence
efficient
treatment
persists
gaps
our
comprehension
pathophysiology
associated
this
envenomation.
Here,
we
explored
interaction
between
venom
extract
derived
from
T.
processionea
voltage-
ligand-gated
ion
channels
receptors.
By
conducting
electrophysiological
analyses,
discovered
ex
vivo
evidence
highlighting
role
TPTX
Language: Английский